Monica Lane

A novel HLA Class II presentation prediction algorithm deciphers immunogenic CD4 epitopes specific to KRAS G12C

Daniel J. Sprague, Meghan G. Hart, Joshua S. Klein, Sonia Kounlavouth et autres

Abstract Accurate prediction of peptide presentation by HLA molecules is important for generation of effective individualized cancer vaccines and immunotherapies. While presentation prediction algorithms for HLA class I have been successfully applied in the context of such therapies, improved prediction algorithms for …

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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results

Amy Rappaport, Chrisann Kyi, Monica Lane, Meghan G. Hart et autres

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Abstract 904: AI platform provides an EDGE and enables state-of-the-art identification of peptide-HLAs for the development of T cell inducing vaccines

Joshua S. Klein, Daniel J. Sprague, Monica Lane, Meghan G. Hart et autres

Abstract T cell inducing vaccines are key for the development of effective therapies against cancer and infectious diseases. Peptides, presented by Human Leukocyte Antigens (HLAs), are the targets of T cells, and their identification is therefore critical to the development of such …

Abstract 2267: HLA-DR-restricted CD4 T cell responses to KRAS G12C in healthy donors linked to bacterial mimotope: lessons for KRAS neoantigen vaccines in cancer patients

Christine D. Palmer, Meghan G. Hart, Sonia Kounlavouth, Harshni Venkatraman et autres

Abstract Mutations in the KRAS gene are among the most common driver mutations in cancer. Targeting KRAS G12C mutations has shown some promise in clinical studies, though acquired resistance mutations pose a challenge for small molecule-based monotherapies. Vaccines targeting KRAS mutations remain …

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Abstract 5364: Language modeling of peptide-HLA interactions achieves state-of-the-art performance on prediction of peptide presentation by HLA Class II

Daniel J. Sprague, Joshua S. Klein, Ítalo Faria do Valle, Olivia Petrillo et autres

Abstract Precise and sensitive prediction of neoantigen presentation to the immune system via human leukocyte antigen (HLA) class II molecules remains a challenge despite the early success of neural networks applied to HLA class I. However, it is necessary to address this …

Abstract 3578: Optimization of shared neoantigen vaccine design to increase vaccine potency: From bench to bedside and back

Amy Rappaport, Christine D. Palmer, Annie Shen, Claudia X. Dominguez et autres

Abstract Vaccines targeting neoantigens identified from common tumor driver mutations are of increasing interest as evidence of clinical benefit builds, and opportunities to combine such vaccines with immune modulators are growing. Our individualized neoantigen vaccine (GRANITE) has shown clinical benefit and strong, …

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Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s disease

Melissa Rotunno, Monica Lane, Wenfei Zhang, Pavlina Wolf et autres

Parkinson's disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Better understanding of the underlying disease mechanism(s) is an urgent need for the development of disease-modifying therapeutics. Limited studies have been performed in large patient cohorts …

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Biomarker and pathway analysis in Pompe disease

Kelly L. George, Rena C. Baek, Monica Lane, Petra Oliva et autres

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Comprehensive exploratory study to identify novel biomarkers of Pompe disease

Kelly L. George, Rena C. Baek, Monica Lane, Martha D. Stapels et autres

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Integrated approaches for Fabry disease biomarker discovery and qualification

Petra Oliva, Mahmud Hossain, Monica Lane, Martha D. Stapels et autres

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Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

Hervé Husson, Sarah E. Moreno, Laurie A. Smith, Mandy M. Smith et autres

Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation of fluid-filled kidney cysts and progression to end-stage renal disease. A mechanistic understanding of cystogenesis is crucial for the development of viable therapeutic options. Here, we identify CDK5, a …

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Cancer control: special populations.

Harvey H. Sirota, Rubovits Dr, Cousins Jh, A D Weinberg et autres