Mandy M. Smith

Quality standards for the management of alcohol-related liver disease: consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology ARLD special interest group

Richard A. Parker, Michael E. Allison, Seonaid Morag Anderson, Richard Aspinall et autres

OBJECTIVE: Alcohol-related liver disease (ALD) is the most common cause of liver-related ill health and liver-related deaths in the UK, and deaths from ALD have doubled in the last decade. The management of ALD requires treatment of both liver disease and alcohol …

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Correction of cilia structure and function alleviates multi-organ pathology in Bardet–Biedl syndrome mice

Hervé Husson, Nikolay O. Bukanov, Sarah E. Moreno, Mandy M. Smith et autres

Bardet-Biedl syndrome (BBS) is a pleiotropic autosomal recessive ciliopathy affecting multiple organs. The development of potential disease-modifying therapy for BBS will require concurrent targeting of multi-systemic manifestations. Here, we show for the first time that monosialodihexosylganglioside accumulates in Bbs2-/- cilia, indicating impairment …

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CXA-10, a Nitrated Fatty Acid, Is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy

CYNTHIA M. ARBEENY, Hong Ling, Mandy M. Smith, Stephen O’Brien et autres

B, and SMAD signaling pathways, respectively. Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. In the present study, we evaluated the effects of chronic treatment with …

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Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

Hervé Husson, Sarah E. Moreno, Laurie A. Smith, Mandy M. Smith et autres

Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation of fluid-filled kidney cysts and progression to end-stage renal disease. A mechanistic understanding of cystogenesis is crucial for the development of viable therapeutic options. Here, we identify CDK5, a …

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LibGuides: Science Issues Analysis : DNA fingerprinting

Mandy M. Smith

LibGuides: Science Issues Analysis : Cloning

Mandy M. Smith

Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats

Hong Ling, Eric Roux, Donna M. Hempel, Jingzang Tao et autres

Considerable evidence has demonstrated that transforming growth factor β (TGF-β) plays a key role in hepatic fibrosis, the final common pathway for a variety of chronic liver diseases leading to liver insufficiency. Although a few studies have reported that blocking TGF-β with …

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Positive and Negative Regulation of Poly(A) Nuclease

David A. Mangus, Matthew C. Evans, Nathan S. Agrin, Mandy M. Smith et autres

PAN, a yeast poly(A) nuclease, plays an important nuclear role in the posttranscriptional maturation of mRNA poly(A) tails. The activity of this enzyme is dependent on its Pan2p and Pan3p subunits, as well as the presence of poly(A)-binding protein (Pab1p). We have …

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Identification of Factors Regulating Poly(A) Tail Synthesis and Maturation

David A. Mangus, Mandy M. Smith, Jennifer M. McSweeney, Allan Jacobson

Posttranscriptional maturation of the 3' end of eukaryotic pre-mRNAs occurs as a three-step pathway involving site-specific cleavage, polymerization of a poly(A) tail, and trimming of the newly synthesized tail to its mature length. While most of the factors essential for catalyzing these …

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Impact of DNA fingerprinting technology on society.

Jessica P. Morgan, Mandy M. Smith, Matthew Francis McGovern

DNA fingerprinting is an enigma to many jurists, as it can be extremely technical and very confusing. This composition explains important concepts such as what DNA is and why it can be so precise in the confirmation of a suspect. An investigation …