R Wilson

Evaluating Risk Factors for Trastuzumab-Deruxtecan Pneumonitis in Patients With Metastatic Breast Cancer

R Wilson, J. Henricks, Tyler Haddad, Osama Ahmed et autres

Abstract Rationale: Trastuzumab deruxtecan (T-DXd) treatment improved survival in HER2 positive and HER2-low metastatic breast cancer patients. However, treatment with T-DXd was associated with a significant risk of pneumonitis. Currently, there are no studies evaluating pre-treatment risk factors for T-DXd pneumonitis. To …

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Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer

Jonathan Henricks, Tyler Haddad, Omair Ahmed, Jonathan E. Schoenhals et autres

BACKGROUND: Trastuzumab deruxtecan (T-DXd) is FDA-approved for treatment of patients with HER2 positive and HER2-low metastatic breast cancer. Currently, there is limited understanding of pre-treatment risk factors for pneumonitis associated with T-DXd. METHODS: Consecutive breast cancer patients who received at least one …

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Large library docking and biophysical analysis of small molecule TMPRSS2 inhibitors

Bryan J. Fraser, Nicholas Young, Brian J. Bender, Stefan Gahbauer et autres

Transmembrane protease, serine -2 (TMPRSS2) is an essential host entry factor in human airways for SARS-CoV-2 and influenza A/B and has presented as a target for antiviral drug development; however, no clinically viable, oral small molecule TMPRSS2 inhibitors have been developed to …

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COVID-19 in the Setting of HIV and Severe Hemophilia A: A Case Report

R Wilson, Chae Ko, Rahul Kashyap

Introduction: A hyperactive immune response is the driving force behind severe Coronavirus disease 2019 (COVID-19). Complications of severe COVID-19 include acute respiratory distress syndrome, acute respiratory failure, and increased risk of venous thromboembolism (VTE). The management of patients with COVID-19 includes respiratory …

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Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography

Lei Wang, Hsiou‐Ting Kuo, Zhengxing Zhang, Chengcheng Zhang et autres

Abstract Background Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to potentially fewer side effects, internalization of agonists may lead to …

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Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography

Lei Wang, Hsiou‐Ting Kuo, Zhengxing Zhang, Chengcheng Zhang et autres

Abstract Background Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to potentially fewer side effects, internalization of agonists may lead to …

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Stabilization of 68Ga-labeled [Thz14]Bombesin(7–14) analogue for imaging gastrin-releasing peptide receptor expression with positron emission tomography

Lei Wang, Hsiou‐Ting Kuo, Zhengxing Zhang, Chengcheng Zhang et autres

Bronchiectasis

R Wilson, Diana Bilton

Abstract A bronchiectatic lung contains permanently dilated subsegmental airways that are inflamed, tortuous, and often partially or totally obstructed with secretions. Pathogenesis involves airway inflammation which can cause further bacteria-driven host-mediated lung damage. Causes include developmental defects, damage caused by previous infection, …

Determinants of survival in the European Bronchiectasis Registry(EMBARC)

Stefano Aliberti, Rosario Menéndez, Francesco Blasi, Felix C. Ringshausen et autres

There is limited data on mortality in bronchiectasis (BE). Risk factors (RF) for mortality over up to 4 years were examined using Cox’s proportional hazards regression in the EMBARC registry, an observational cohort study across 30 European countries beginning in 2015. 13,051 …

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Prognosis of CT-derived Fractional Flow Reserve in the Prediction of Clinical Outcomes

Charis McNabney, Stephanie Sellers, R Wilson, Shmuel Hart et autres

Purpose To examine the prognostic implication of fractional flow reserve (FFR) derived from coronary CT (FFRCT) in routine clinical practice. Materials and Methods Patients referred for FFRCT analysis at a single center between October 2015 and June 2017 were retrospectively included and …

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Perinodular Vascularity Distinguishes Benign Intrapulmonary Lymph Nodes From Lung Cancer on Computed Tomography

Joseph Barnett, Ilaria Pulzato, R Wilson, Simon Padley et autres

PURPOSE: A common diagnostic dilemma in the assessment of small pulmonary nodules on computed tomography (CT) is in distinguishing benign intrapulmonary lymph nodes (IPLNs) from small primary pulmonary malignancies. Several CT features have been described of IPLNs, including attachment to a pleural …

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A phase I dose escalation multi-centre study of crizotinib (MET inhibitor) combined with binimetinib (MEK inhibitor) in patients with advanced solid tumours

R Wilson, Prashanth Hari Dass, Sandra Van Schaeybroeck, Elena Élez et autres

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