Nicolas Drillaud

Reply to the Correspondence: "Heterogeneity Among Plasma-Derived von Willebrand Factor Concentrates: Implications for Comparative Effectiveness Analyses"

Valérie Horvais, Catherine Ternisien, Julien Denis le Sève, Philippe Beurrier et autres

Comment on: Heterogeneity Among Plasma-Derived von Willebrand Factor Concentrates: Implications for Comparative Effectiveness Analyses Semin Thromb Hemost eFirst DOI: 10.1055/a-2870-6103 10.1055/a-2870-6103 We are grateful for the opportunity to reply to the correspondence from Professors Hermans and Sidonio[ 1 ] and appreciate the …

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Predominance of autoimmune heparin-induced thrombocytopenia in a nephrology department

Manuel Laslandes, Claire Leman, Charles Ronsin, Simon Ville et autres

Predominance of

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Optimizing Perioperative Management of Haemophilia B With rFIX‐FP: Pharmacokinetic Validation of the Hemoptidose Tool

Xavier Delavenne, Célia Vollard, Nicolas Drillaud, Sabine Marie Castet et autres

BACKGROUND: Surgical management of haemophilia B requires precise factor IX replacement to ensure adequate haemostasis while optimizing factor consumption. Extended half-life rFIX-FP simplifies perioperative management but exhibits substantial pharmacokinetic variability. PK-guided dosing is recommended by WFH guidelines, yet validated tools for perioperative …

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Implantation nationale de la thérapie génique de l’hémophilie B en France - De la planification théorique à l’amélioration organisationnelle : enseignements après trois ans

Yesim Dargaud, Laurent Frenzel, Birgit Frotscher, Nicolas Drillaud et autres

La prise en charge de l’hémophilie s’est considérablement améliorée au cours des 15 dernières années, grâce au développement des traitements non substitutifs, du facteur VIII à demi-vie ultra-prolongée et de la thérapie génique, qui constitue une avancée majeure et représente aujourd’hui une …

Safety of von Willebrand factor substitution for neuraxial anesthesia in women with persistent von Willebrand deficiency at delivery

Yaquine Mechelfekh, Sarah Guérin, Kenza Kali, Pauline Noyel et autres

Background: Neuraxial anesthesia (NA) constitutes a risk for patients with bleeding disorders, the main hemorrhagic adverse effect being spinal epidural hematoma. No clear recommendation has been issued concerning NA use for delivery in patients with von Willebrand disease (VWD) whose von Willebrand …

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Current use and limitations of direct thrombin inhibitors in pediatric ECMO: A European survey

Philippe Gardeton, Nicolas Drillaud, Ariane Willems, Nicolas Joram et autres

Introduction Direct thrombin inhibitors (DTIs) are an alternative to unfractionated heparin during pediatric ECMO. We aimed to describe their use and limitations across Europe. Methods Fifty-two pediatric EuroELSO centers were surveyed from July to December 2025. Thirty-seven respondents were analyzed across 11 …

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Vonicog Alfa versus Plasma-Derived von Willebrand Factor during Hospitalization: Results of an Observational Retrospective Multicenter Study

Valérie Horvais, Catherine Ternisien, Julien Denis-Le-Sève, Philippe Beurrier et autres

Abstract Available products for the treatment of von Willebrand disease (VWD) now include a new recombinant von Willebrand factor (rVWF) in addition to plasma-derived concentrates (pdVWF). However, these two therapies have never been compared directly in either preclinical studies or real-world inpatient …

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NuPOWER (Nuwiq for Perioperative management Of patients With haemophilia A on Emicizumab Regular prophylaxis): protocol for an open-label, single-arm, multicentre study

Alok Srivastava, Angela Kanny, Florian Peter Länger, Cornelia Kubicek-Hofmann et autres

INTRODUCTION: Despite the known haemostatic action of emicizumab (Hemlibra) in haemophilia A patients, its role in the prevention and control of bleeding in high-demand haemostatic situations, such as major surgery, remains to be determined. Patients receiving regular emicizumab prophylaxis often require concomitant …

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Impact of Systematic Joint Examination (Ultrasound, Functional and Physical) on Treatment Management Decisions in Patients With Haemophilia A in France: Final Data From the Prospective, Observational A‐MOVE Study

Nicolas Drillaud, Virginie Barbay, Jean Baptiste Valentin, Romain Jailler et autres

BACKGROUND: Haemophilia management aims to prevent bleeding and preserve joint function. Changes in patients' joint health may influence physicians' decisions to adjust treatment. The Haemophilia Joint Health Score (HJHS) and Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score assess joint health but …

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Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST)

Virginie Barbay, Yohann Repessé, Dominique Desprez, Nicolas Drillaud et autres

Abstract The Hemophilia Functional Ability Scoring Tool (Hemo-FAST), consisting of a patient-reported outcome (PRO) part and a clinician-reported outcome (ClinRO) part, was developed as a rapid and effective tool to assess functional mobility in clinical practice. This study (NCT04731701) aimed to validate …

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The concept of immunothrombosis in pancreas transplantation

Christophe Masset, Nicolas Drillaud, Catherine Ternisien, Nicolas Degauque et autres

Early failure of a pancreatic allograft due to complete thrombosis has an incidence of approximately 10% and is the main cause of comorbidity in pancreas transplantation. Although several risk factors have been identified, the exact mechanisms leading to this serious complication are …

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Pratique de l’échographie ostéoarticulaire chez le patient hémophile : résultats d’un consensus français en ligne

Nicolas Poursac, Laurent Frenzel, V. Barbay, Sylvain Breton et autres

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