Kunihiko Ikeguchi

Efficacy and Safety of a Tailored Dosing Strategy with High-Dose IncobotulinumtoxinA at Flexible Injection Intervals for Cervical Dystonia: An Open-Label, Uncontrolled, Single-Arm Study in Japan

Akira Tamagawa, Masahiro Horiuchi, Takenori Abe, Shinichi Matsumoto et autres

BACKGROUND: This prospective, multicenter, open-label, single-arm study (jRCT2031230690) evaluated the efficacy and safety of a tailored dosing strategy of incobotulinumtoxinA, including high doses (up to 500 U) and flexible injection intervals (as short as 6 weeks), in Japanese patients with cervical dystonia …

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Persistent expression of dopamine-synthesizing enzymes 15 years after gene transfer in a primate model of Parkinson disease

Yoshihide Sehara, Ken’ichi Fujimoto, Kunihiko Ikeguchi, Yuko Katakai et autres

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Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease

Yoshihide Sehara, Ken’ichi Fujimoto, Kunihiko Ikeguchi, Yuko Katakai et autres

Restoring dopamine production in the putamen through gene therapy is a straightforward strategy for ameliorating motor symptoms for Parkinson's disease (PD). In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity-based primate model of PD, we previously showed the safety and efficacy of adeno-associated viral (AAV) vector-mediated …

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Prevention of Cerebral Embolism Progression by Emergency Surgery of the Left Atrial Myxoma

Syuichi Tetsuka, Kunihiko Ikeguchi

A 21-year-old woman developed left hemiparesis during work and was hospitalized. Her National Institutes of Health Stroke Scale score was 4. Hyperintense areas in the left basal ganglia, corona radiata, and cortex of the temporal lobe were found by brain diffusion-weighted magnetic …

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Antibodies to a brain‐type creatine kinase associated with paraneoplastic neurological syndromes

Syuichi Tetsuka, Hideaki Yamasawa, Kunihiko Ikeguchi, Ken’ichi Fujimoto

Abstract Background Previously, we identified a brain‐type creatine kinase antibody to be associated with paraneoplastic cerebellar degeneration using a proteomic approach. Immunohistochemistry showed that this antibody reacted with both mouse cerebellar neurons and bladder cancer tissues. Furthermore, we detected this antibody in …

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Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis

Syuichi Tetsuka, Kenichi Fujimoto, Kunihiko Ikeguchi

Previous studies addressing preoperative steroid treatment have revealed that control of myasthenia gravis (MG) with steroids prior to surgery appeared to stabilize postoperative status. The purpose of our study was to clarify the clinical benefits of the preoperative programmed high-dose steroid treatment …

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Utility of cystatin C for renal function in amyotrophic lateral sclerosis

Syuichi Tetsuka, Mitsuya Morita, Kunihiko Ikeguchi, Imaharu Nakano

OBJECTIVES: Creatinine (Cr) as a marker of renal function has limited value in amyotrophic lateral sclerosis (ALS) because patients with ALS have reduced muscle mass. Thus, there is a need for alternative methods of assessing renal function. Cystatin C (CysC), which is …

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Creatinine/cystatin C ratio as a surrogate marker of residual muscle mass in amyotrophic lateral sclerosis

Syuichi Tetsuka, Mitsuya Morita, Kunihiko Ikeguchi, Imaharu Nakano

Abstract Aim Identification of sensitive surrogate markers that indicate disease progression in amyotrophic lateral sclerosis might be useful in clinical trials and clinical care. Determination of the creatinine/cystatin C (Cr/CysC) ratio eliminates the effect of renal function on serum creatinine levels; therefore, …

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[Food-borne botulism].

Yuko Nakamura, Mikio Sawada, Kunihiko Ikeguchi, Imaharu Nakano

Botulism is a neuroparalytic disease caused by neurotoxins produced by Clostridium botulinum, and classically presents as palsies of cranial nerves and acute descending flaccid paralysis. Food-borne botulism is the most common form of botulism, and caused by preformed neurotoxins produced by Clostridium …

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[Food-borne botulism].

Yuko Nakamura, Mikio Sawada, Kunihiko Ikeguchi, Imaharu Nakano

Botulism is a neuroparalytic disease caused by neurotoxins produced by Clostridium botulinum. Food-borne botulism is a kind of exotoxin-caused food intoxication. Although this disease is rarely reported in Japan now, it is a cause of great concern because of its high mortality …

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AADC gene therapy for Parkinson disease: Four years of follow-up

Shin‐ichi Muramatsu, Ken’ichi Fujimoto, Seiya Kato, Sayaka Asari et autres

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[Practice of botulism].

Kunihiko Ikeguchi

Botulism is a rare but potentially life-threatening motor and autonomic paralytic syndrome caused by the action of neurotoxins released by Clostridium botulinum. The modern syndromes of botulism have 6 forms: 4 naturally occurring syndromes and 2 human-induced syndromes. Food-borne botulism is caused …

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