Yoshihide Sehara

Correction: Post-ischemic modification of neurogenesis and oligodendrogenesis in rodent models

Yoshihide Sehara, Shinya Mochizuki, Reiji Yamazaki

[This corrects the article DOI: 10.3389/fncir.2026.1803118.].

jp (code pays fourni par la source)

AAV9/hGLA gene therapy reduces podocyte GL-3 accumulation in a Fabry disease mouse model

Takahiro Kanai, Yuka Hayashi, Yoshihide Sehara, Mitsuaki Yoshino et autres

jp (code pays fourni par la source)

Post-ischemic modification of neurogenesis and oligodendrogenesis in rodent models

Yoshihide Sehara, Shinya Mochizuki, Reiji Yamazaki

Neurogenesis and oligodendrogenesis occur throughout life under both physiological and pathophysiological conditions. Brain insults such as ischemia, trauma, epilepsy, or Alzheimer disease result in the promotion of neurogenesis and oligodendrogenesis; however, the mechanisms and the roles of this promotion are not well …

jp (code pays fourni par la source)

Vareicella zoster infection presenting with dizziness, hearing loss, dysarthria and dysphagia in a single side

Yuki Endo, Yoshihide Sehara, Masaaki Tamura, Keisuke Okubo

jp (code pays fourni par la source)

Two cases of Tapia’s syndrome which mimic cerebrovascular diseases in the perioperative period

Takayuki Asayama, Yoshihide Sehara, Jun Mimuro

jp (code pays fourni par la source)

Limitation of Assay Sensitivity Revealed by the Improvement of Cell-Based Assay Against Various Adeno-Associated Virus Serotypes

Ryota Watano, Kenji Ohba, Yoshihide Sehara, Yasushi Saga et autres

Gene therapy using adeno-associated virus (AAV) vectors is currently expanding to broad clinical applications. As the presence of a neutralizing antibody (NAb) against AAV capsids significantly restrains their efficacy, an accurate evaluation of NAb status is crucial for selecting appropriate candidates for …

jp (code pays fourni par la source)

Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus

Yoshihide Sehara, Yuki Hashimotodani, Ryota Watano, Kenji Ohba et autres

It is established that neurogenesis of dentate gyrus is increased after ischemic insult, although the regulatory mechanisms have not yet been elucidated. In this study, we focused on Ezh2 which suppresses gene expression through catalyzing trimethylation of lysine 27 of histone 3. …

jp (code pays fourni par la source)

Therapeutic Strategy for Fabry Disease by Intravenous Administration of Adeno-Associated Virus 9 in a Symptomatic Mouse Model

Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba et autres

Fabry disease (FD) is an inherited lysosomal storage disease caused by deficiency of α-galactosidase A (α-Gal A), an enzyme that hydrolyzes glycosphingolipids in lysosome. Accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3) in tissues, induces cellular dysfunction leading to multi-organ disorder. Gene therapy is …

jp (code pays fourni par la source)

Featured Cover

Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi et autres

The cover image is based on the Research Article Therapeutic strategy for Fabry disease by intravenous administration of adeno-associated virus 2 or 9 in α-galactosidase A-deficient mice by Yuka Hayashi et al., https://doi.org/10.1002/jgm.3560.

Therapeutic strategy for Fabry disease by intravenous administration of adeno‐associated virus 2 or 9 in α‐galactosidase A‐deficient mice

Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi et autres

Abstract Background Fabry disease (FD) is an inherited lysosomal storage disease caused by deficiency of α‐galactosidase A (α‐Gal A) encoded by the GLA gene. The symptoms of FD occur as a result of the accumulation of globotriaosylceramide (Gb3), comprising a substrate of …

jp (code pays fourni par la source)

Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality

Kenji Ohba, Yoshihide Sehara, Tatsuji Enoki, Junichi Mineno et autres

Adeno-associated virus (AAV) vectors are promising tools for gene therapy. The current AAV vector system produces an abundance of empty capsids that are eliminated before clinical use, leading to increased costs for gene therapy. In the present study, we established an AAV …

jp (code pays fourni par la source)

Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy

Yoshihide Sehara, Kyoichiro Tsuchiya, Ichizo Nishino, Hirotake Sato et autres

A 72-year-old woman presented with gradually-worsening myalgia and muscle weakness of the proximal lower limbs as well as elevated serum creatine kinase level. Based on a clinicoseropathological examination including a muscle biopsy, she was diagnosed with anti-signal recognition particle (SRP) myopathy. Although …

jp (code pays fourni par la source)