E Harjulahti

Lipid-Lowering Medication and Outcomes After Anatomical and Functional Imaging in Suspected Coronary Artery Disease

Teemu Maaniitty, Matias Mäenpää, E Harjulahti, I Kujala et autres

BACKGROUND: Anatomical and functional imaging identify different phenotypes of coronary artery disease (CAD) that may have implications for lipid-lowering medication (LLM). OBJECTIVES: The aim of this study was to assess the associations between LLM and long-term outcomes after combined anatomical and functional …

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Quantitative myocardial blood flow and long-term outcome benefit from revascularization

Teemu Maaniitty, Wail Nammas, Ruurt Jukema, P. Van Diemen et autres

Abstract Background There is controversy regarding the outcome benefit from myocardial revascularization in patients with chronic coronary artery disease (CAD). We hypothesized that severely reduced regional stress myocardial blood flow (MBF) quantified by [15O]H2O positron emission tomography (PET) is associated with prognostic …

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Hybrid CTA/PET imaging of coronary artery disease in non-diabetic, prediabetic and diabetic patients evaluated for chest pain

Matias Mäenpää, I Kujala, E Harjulahti, Iida Stenström et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Academy of Finland Finnish foundation for cardiovascular research. Background Patients with prediabetes or diabetes are at increased risk of developing cardiovascular disease and cardiac events. First-line …

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The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging

Matias Mäenpää, I Kujala, E Harjulahti, Iida Stenström et autres

BACKGROUND: Patients with prediabetes or diabetes are at increased risk of developing cardiovascular disease and adverse outcomes. First-line coronary computed tomography angiography (CTA) followed by selective use of positron emission tomography (PET) myocardial perfusion imaging is a feasible strategy to diagnose and …

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The use of lipid-lowering medication after diagnostic imaging procedures in patients with chest pain

Teemu Maaniitty, Matias Mäenpää, E Harjulahti, I Kujala et autres

Abstract Background Coronary CT angiography (CTA) combined with myocardial perfusion imaging accurately detects both non-obstructive and obstructive coronary artery disease (CAD). Lipid-lowering therapy is known to effectively reduce cardiovascular events, but the impact of non-invasive imaging findings on the usage of lipid-lowering …

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Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [15O] water positron emission tomography study

E Harjulahti, Teemu Maaniitty, Wail Nammas, Iida Stenström et autres

Abstract Purpose We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods Global and segmental …

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361Association of quantitative myocardial perfusion characteristics and coronary atherosclerosis in patients with normal myocardial blood flow

Teemu Maaniitty, Iida Stenström, E Harjulahti, Maija Mäki et autres

Background: Normal hyperemic myocardial blood flow (MBF) accurately excludes hemodynamically significant coronary artery disease (CAD). However, patients with normal absolute MBF may show relative regional differences in perfusion. We hypothesized that subtle alterations in myocardial perfusion, although within "normal range" in absolute …

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P309Prognostic value of global stress myocardial blood flow in patients with suspected obstructive coronary artery disease

E Harjulahti, Iida Stenström, Teemu Maaniitty, Wail Nammas et autres

Funding Acknowledgements: None Background: We have previously demonstrated that reduced regional stress myocardial blood flow (MBF, < 2.3 ml/g/min) by 15O-water positron emission tomography (PET) perfusion imaging accurately detects obstructive coronary artery disease (CAD) and provides prognostic information. It has also been …

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Prognostic value of global and regional myocardial blood flow assessed by 15O-water positron emission tomography in patients with suspected coronary disease

E Harjulahti

Coronary computed tomography angiography (CCTA) combined with positron emission tomography (PET) myocardial perfusion imaging (MPI) using 15O-water is an effective non-invasive method to detect or exclude obstructive coronary artery disease (CAD) in patients with intermediate pre-test disease probability. Prognostic value of myocardial …