Maija Mäki

Lymfactin® gene therapy with vascularized lymph node transfer reduces compression-free swelling and enhances quality of life in breast cancer-related lymphedema: Final Phase I trial results

Susanna Pajula, Anne Saarikko, Sinikka Suominen, Ilkka Kaartinen et autres

BACKGROUND: Lymfactin® is a gene-therapy vector encoding vascular endothelial growth factor C designed to promote lymphatic vessel growth. It is administered during vascularized lymph node transfer (VLNT) to treat breast cancer-related lymphedema. This study presents the final efficacy and long-term safety results …

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Phase II Study Shows the Effect of Adenoviral Vascular Endothelial Growth Factor C and Lymph Node Transfer in Lymphedema

Eeva H. Rannikko, Susanna Pajula, Sinikka Suominen, Juha Kiiski et autres

BACKGROUND: Breast cancer-related lymphedema is a common complication lacking medical treatment. Lymfactin is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth factor C expression. The authors' aim was to evaluate the therapeutic effect of …

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Editorial

Kirsi Sonck-Rautio, Riikka Aro, Liia-Maria Raippalinna, Maija Mäki

nonPeerReviewed

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Phase 1 Lymfactin® Study: 24-month Efficacy and Safety Results of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema

Ida-Maria Leppäpuska, Pauliina Hartiala, Sinikka Suominen, Erkki Suominen et autres

BACKGROUND: Lymphedema is a common problem after breast cancer treatment. Lymfactin® is a prolymphangiogenic growth factor vector inducing the expression of human vascular endothelial growth factor C (VEGF-C). It promotes growth and repair of lymphatic vessels. METHODS: Lymfactin® was combined with microvascular …

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“Tarkoittaako kehittäminen aina seinien rakentamista?”

Aura Kivilaakso, Maija Mäki

Tässä artikkelissa tarkastellaan Turun historialliseen keskustan ja yliopistojen alueen kehittämissuunnitelmaa suhteessa kaupunkilaisten kokemuksiin ja näkemyksiin kaupunkikeskustasta.Artikkelissa Turun historiallisen keskustan kehittämistä lähestytään kaupunkilaisten osallisuuden ja vaikutusmahdollisuuksien näkökulmasta.Osallisuus nähdään artikkelissa nykykaupunkisuunnittelua ohjaavana narratiivina.Aineistona tutkimuksessa on kehittämissuunnitelman lisäksi hyödynnetty kävelyhaastattelu-ja havainnointiaineistoa.Tulokset kiinnittyvät kaupungissa liikkumiseen, kulkureitteihin …

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Long-term Results of Microvascular Lymph Node Transfer: Correlation of Preoperative Factors and Operation Outcome

Eeva H. Rannikko, Sinikka Suominen, Anne Saarikko, Tiina Viitanen et autres

Our objective was to analyze whether a correlation could be observed between preoperative factors and microvascular lymph node transfer outcome after long-term follow-up. METHODS: We included 67 patients in this retrospective case series. The incidence of cellulitis, the difference of arm circumference, …

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Utflykter till framtidens stränder – diskussioner om kollaps

Maija Mäki

Recencion av Peter Bjerregaard & Kyrre Kverndokk (red.): Kollaps. På randen av fremtiden. Illustrert av Kristen Jensen Helgeland. Dreyers Forlag Oslo, 2018.

COOLEST STUDENT PAPERS AT FINLAND FUTURES RESEARCH CENTRE 2019–2020 : Tulevaisuuden tutkimuskeskuksen valittuja opiskelijatöitä 2019–2020

Matti Minkkinen, Toni Ahlqvist, Akhgar Kaboli, Jari Kolehmainen et autres

Absolute Stress Myocardial Blood Flow After Coronary CT Angiography Guides Referral to Invasive Angiography

Iida Stenström, Teemu Maaniitty, Valtteri Uusitalo, Heikki Ukkonen et autres

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361Association of quantitative myocardial perfusion characteristics and coronary atherosclerosis in patients with normal myocardial blood flow

Teemu Maaniitty, Iida Stenström, E Harjulahti, Maija Mäki et autres

Background: Normal hyperemic myocardial blood flow (MBF) accurately excludes hemodynamically significant coronary artery disease (CAD). However, patients with normal absolute MBF may show relative regional differences in perfusion. We hypothesized that subtle alterations in myocardial perfusion, although within "normal range" in absolute …

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P309Prognostic value of global stress myocardial blood flow in patients with suspected obstructive coronary artery disease

E Harjulahti, Iida Stenström, Teemu Maaniitty, Wail Nammas et autres

Funding Acknowledgements: None Background: We have previously demonstrated that reduced regional stress myocardial blood flow (MBF, < 2.3 ml/g/min) by 15O-water positron emission tomography (PET) perfusion imaging accurately detects obstructive coronary artery disease (CAD) and provides prognostic information. It has also been …

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Combined Surgical Treatment for Chronic Upper Extremity Lymphedema Patients

Ida-Maria Leppäpuska, Erkki Suominen, Tiina Viitanen, Eeva H. Rannikko et autres

BACKGROUND: Upper limb lymphedema is a common problem after axillary lymph node dissection. Lymphatic drainage can be improved by microvascular lymph node transfer, whereas liposuction can be used to reduce arm volume and excess of adipose tissue. We present the results of …

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