Viktória Humli

Protective Effect of Selegiline (R-deprenyl) in Aminoglycoside-Induced Hearing Loss

Viktória Humli, Judit Szepesy, G. Zsilla, Ildikó Miklya et autres

Aminoglycoside antibiotics remain indispensable despite their ototoxicity. Like other sensorineural forms, aminoglycoside-induced hearing loss (AGIHL) has no effective pharmacotherapy. Oxidative stress, apoptosis, excitotoxicity and inflammation are key pathological factors of the disease. We hypothesised that selegiline, an irreversible monoamine oxidase-B (MAO-B) inhibitor …

hu, at, nl (code pays fourni par la source)

Drug regulations and trafficking: Synthetic cannabinoids and cathinones in Hungary

József Haller, Éva Rompos, Írisz Szabó, Viktória Humli et autres

hu (code pays fourni par la source)

Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice

Judit Szepesy, Viktória Humli, János Farkas, Ildikó Miklya et autres

Age-related hearing loss (ARHL), a sensorineural hearing loss of multifactorial origin, increases its prevalence in aging societies. Besides hearing aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent ARHL. We hypothesized that selegiline, an antiparkinsonian …

hu (code pays fourni par la source)

Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice

Daniel Balazs Fulop, Viktória Humli, Judit Szepesy, Virag Ott et autres

Abstract Pituitary adenylate cyclase activating polypeptide (PACAP) is a regulatory and cytoprotective neuropeptide, its deficiency implies accelerated aging in mice. It is present in the auditory system having antiapoptotic effects. Expression of Ca2+-binding proteins and its PAC1 receptor differs in the inner …

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Protective effect of rasagiline in aminoglycoside ototoxicity

Gábor Polony, Viktória Humli, Rómeó D. Andó, Máté Aller et autres

hu (code pays fourni par la source)