Basma Talib Al-Sudani

Efficacy of a SIRT1 Aptamer as an Anti-Angiogenic and Antioxidant Agent in in vitro, ex vivo, and in vivo Models

Noralhuda Akram Yahya, Bahir Abdul Razzaq Mshimesh, Basma Talib Al-Sudani

Background: Angiogenesis and oxidative stress are closely related processes that facilitate pathological vascular remodeling and cancer progression. Given that sirtuin 1 (SIRT1) modulates endothelial function, redox balance, and angiogenic remodeling in a context-dependent manner. Objective: To investigate the anti-angiogenic and antioxidant activity …

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MiR-155 Expression by Real-Time PCR as a New Tool to Diagnose Prostate Cancer as an Alternative to the Traditional ELISA Assay

Hiba Adil Kadhim, Basma Talib Al-Sudani, Hadeel Saeed Hadi

Prostate cancer is a common malignancy in men, and early detection is essential for effective treatment. While PSA is the most used biomarker, its limitations call for better diagnostic tools. This study aimed to evaluate the diagnostic potential of miR-155 expression using …

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Electroconductive Polypropylene Fumarate-Methoxy Polyethylene Glycol Nanofibers Containing Sitagliptin-Loaded Polypyrrole Nanoparticles for Cardiac Tissue Engineering

Mohamadreza Tavakoli, Marjan Mirhaj, Mina Shahriari-Khalaji, Mastafa H. Al‐Musawi et autres

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Potential Therapeutic Role of Aescin in a Model of Psoriasis in Male Rats

Rafal Wadhah Taher, Ghaith Ali Jasim, Basma Talib Al-Sudani

Abstract Background: Psoriasis is a complex chronic inflammatory skin condition that is influenced by both genetic and environmental factors. Aescin is a natural mixture from Aesculus hippocastanum seeds. It exhibits powerful anti-inflammatory, anti-edematous, anti-oxidant, and vasoprotective properties. Objective: The purpose of this …

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Cytotoxicity of SHIP2 Silencing in MDA-MB-231 Breast Cancer Cell Line

Riyad Naser, Inam Sameh Arif, Basma Talib Al-Sudani, Sayed Mahmood Alqallaf

Background: Breast cancer is a serious global health risk to women. Compared to other forms of BC. Triple negative breast cancer is characterized by a poor prognosis, high levels of aggressiveness and proliferation, and rapid progression. The phosphoinositide 3-kinase/ protein kinase B/ …

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Preparation and evaluation of injectable dosage form for Pemetrexed-monoclonal antibody conjugate

Faten Q. Ibraheem, Nidhal Khazaal Maraie, Basma Talib Al-Sudani

Antibody-drug conjugates (ADCs), a powerful type of pharmaceutical medications that combine immunotherapy and chemotherapy. Pemetrexed is a multitarget antifolate agent that inhibit essential enzymes involve in purine and pyrimidine synthesis, therefore serious toxicities of pemetrexed are due to lack of selectivity despite …

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Evaluation of 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one as a p38 MAPK inhibitor in MCF-7 and MDA-MB-231 breast cancer cell lines

Mohamed Abdul Qader, Intesar Tarik Numan, Basma Talib Al-Sudani, Mohammed A. Abdalqader

الملخص يعد سرطان الثدي الأكثر تشخيصًا بين النساء وثاني أهم سبب لوفيات السرطان. في عام 2020 شكل سرطان الثدي 11.7٪ من الحالات الجديدة على مستوى العالم. في العراق، ارتفع معدل الإصابة بسرطان الثدي من 52.00 لكل 100,000 شخص في عام 2000 إلى …

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Exploring the effect of EX-527 as a selective SIRT1 inhibitor against MCF-7 breast cell line by modulating POLD1 activity

Areege Ibrahim Salih, Bahir Abdul Razzaq Mshimesh, Basma Talib Al-Sudani

سرطان الثدي هو الورم الأكثر انتشارا بين النساء وثالث أكبر سبب للوفاة في جميع انحاء العالم. وبالتالي، فان تحسين تشخيص وفعالية علاج سرطان الثدي يتطلب المزيد من الدراسات لفهم الاليات الجزيئية الكامنة وراء التسبب في المرض. السيرتوين 1 هو عبارة عن انزيم …

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SHIP2 Silencing Enhances Erastin Cytotoxicity in MDA-MB-231 Breast Cancer Cell Line

Rua Abbas Naser Al-Hamdy, Inam Sameh Arif, Basma Talib Al-Sudani

Background: Breast cancer (BC) is a serious health risk to women worldwide. Triple-negative breast cancer (TNBC) is a highly heterogeneous type of breast cancer that is highly malignant, recurrent, and invasive. Despite cancer treatment having developed rapidly in the past decades, TNBC …

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Erastin Induces Ferroptosis and Apoptosis in MDA-MB-231 Breast Cancer Cell Line

Riyad Naser, Inam Sameh Arif, Basma Talib Al-Sudani

Background: Breast cancer (BC) is one of the most malignant types of cancer in women. Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and high recurrence and invasive metastasis rates. Ferroptosis is a non-apoptotic form of cell …

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Deferoxamine-Loaded Trilayer Scaffold Containing Propolis and Sulfated Polysaccharides Promotes In Vivo Wound Healing through Angiogenesis Stimulation

Orooba Al-Hammood, Huda Muhammed Muzher, Ruqaya Hasan Mousa, Vala Vahedian Boroujeni et autres

The skin exhibits a hierarchical structure, and the application of tissue engineering techniques is recommended for the treatment of severe cutaneous injuries. To biologically mimic the structural characteristics of the distinct layers of the skin, the utilization of multilayered scaffolds has become …

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Antibacterial and wound healing stimulant nanofibrous dressing consisting of soluplus and soy protein isolate loaded with mupirocin

Maryam Jahani, Azadeh Asefnejad, Mastafa H. Al‐Musawi, Ahmed Ali Mohammed et autres

Abstract Severe cutaneous injuries may not heal spontaneously and may necessitate the use of supplementary therapeutic methods. Electrospun nanofibers possess high porosity and specific surface area, which provide the necessary microenvironment for wound healing. Here in, the nanofibers of Soluplus-soy protein isolate …

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