Potential Therapeutic Role of Aescin in a Model of Psoriasis in Male Rats

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Abstract Background: Psoriasis is a complex chronic inflammatory skin condition that is influenced by both genetic and environmental factors. Aescin is a natural mixture from Aesculus hippocastanum seeds. It exhibits powerful anti-inflammatory, anti-edematous, anti-oxidant, and vasoprotective properties. Objective: The purpose of this study is to examine the potential effects of aescin on psoriasis inflicted on male rats. Materials and Methods: Thirty-six apparently healthy male rats were divided into six groups, each group were given different treatment for psoriasis. The duration of study was 24 days (10 days induction period + 14 days of treatment). Results: Enzyme-linked immunosorbant assay results showed that the difference among groups was significant ( P < 0.05) according to post hoc test (multiple comparison). Interleukin-1 beta (IL-1β) mean values were lowest in the combination group. Nuclear factor kappa-B (NF-κB) mean values show the lowest reduction in group VI. Malondialdehyde (MDA) values were decreased by the use of all types of treatments in compared with the induction group. The mean values of superoxide dismutase (SOD) were higher in groups III, IV, V, and VI in compared with the induction group. The lowest values of caspase 3 were seen with the use of oral aescin. Conclusion: Aescin, either alone or in combination with clobetasol, was found to decrease IL-1β and NF-κB levels. The highest anti-inflammatory effect was observed with the combination of aescin and clobetasol. Aescin were found to increase SOD and decrease MDA levels.

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