Christophe Guilhot

BVL3572S inhibits HisC and AlaA, exploiting vitamin B6 dependency to kill Mycobacterium tuberculosis

Zainab Edoo, Astrid Lenne-Delmotte, Camille Grosse, Marie Devaere et autres

fr, be, ch (code pays fourni par la source)

Exploiting DprE2 pathway redundancy to enhance potency and overcome resistance to pretomanid in Mycobacterium tuberculosis

Kamel Djaout, Aurore Dreneau, Léo Faïon, Marion Prieri et autres

Tuberculosis (TB), the deadliest infectious disease globally, still poses an enormous public health challenge exacerbated by the rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) M. tuberculosis strains. The bicyclic nitroimidazoles pretomanid (PTM) and delamanid (DLM) represent the most recent class …

fr, sk, us (code pays fourni par la source)

PhoPR variants from several phylogenetic lineages of tuberculosis bacilli respond differently to extracellular signals

Eva Meunier, Carlos A. M. Silva, Wladimir Malaga, David Rengel et autres

ABSTRACT The global spread of Mycobacterium tuberculosis ( MTB ) is facilitated by airborne transmission, a low infectious dose, and the pathogen’s ability to persist in a latent state. Despite sharing over 99% genomic identity, MTB strains and lineages show significant variability …

fr (code pays fourni par la source)

Functional analysis of the rv1371/2/3 operon in mycobacteria

Marcos Gustavo Araujo Schwarz, Paloma Rezende Corrêa, Meydson Benjamim Carvalho Corrêa, Antônio José da Silva Gonçalves et autres

ABSTRACT Mycobacterium tuberculosis is known for its lipid-rich cell wall. Additionally, lipids are also involved in various mycobacterial pathways, such as signaling and energy storage. In this study, using BCG as a model, we aimed to characterize the rv1371/2/3 operon, which is …

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Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Zainab Edoo, Astrid Lenne-Delmotte, Camille Grosse, Marie Devaere et autres

Abstract Tuberculosis remains the leading cause of death from a single infectious agent worldwide, and the growing prevalence of multi-drug resistant Mycobacterium tuberculosis ( Mtb ) underscores the urgent need for antibiotics with novel mechanisms of action. Here, we characterize BVL3572S, a …

fr, be, ch (code pays fourni par la source)

Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes

Andrea Majstorović, Hélène Botella, Sarah M. Schrader, Yaroslav Lavrynchuk et autres

ASBTRACT Antibiotic recalcitrance refers to a slower rate of death for either a bacterial population or a subpopulation of cells upon antibiotic exposure. It complicates treatment of many bacterial infections by contributing to treatment length, treatment failure, disease recurrence, and the emergence …

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How PGL finds a sweet spot in phospholipid membranes: A combined multiscale MD and NMR study

Adrien Schahl, Valérie Réat, Wladimir Malaga, Clément Birbes et autres

fr, jp (code pays fourni par la source)

Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Zainab Edoo, Astrid Lenne-Delmotte, Camille Grosse, Marie Devaere et autres

fr, be, ch (code pays fourni par la source)

Catalytic Cycle of Type II 4′-Phosphopantetheinyl Transferases

Sabine Gavalda, Alexandre Faille, Simone Fioccola, Minh Chau Nguyen et autres

Polyketides are a diverse class of compounds with significant interest in the pharmaceutical industry. They are synthesized by polyketide synthases (PKSs), which consist of large multienzyme systems. Post-translational modification of acyl-carrier protein (ACP) domains is crucial for PKS and fatty acid synthase …

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Altered serine metabolism promotes drug tolerance in Mycobacterium abscessus via a WhiB7-mediated adaptive stress response

Célia Bernard, Yi Liu, Gerald J Larrouy-Maumus, Christophe Guilhot et autres

ABSTRACT Mycobacterium abscessus is an emerging opportunistic pathogen responsible for chronic lung diseases, especially in patients with cystic fibrosis. Treatment failure of M. abscessus infections is primarily associated with intrinsic or acquired antibiotic resistance. However, there is growing evidence that antibiotic tolerance, …

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Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Stephen Adonai Leon‐Icaza, Salimata Bagayoko, Romain Vergé, Nino Iakobachvili et autres

Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in CF patient lung remains rudimentary. Here, we used human …

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Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

Wladimir Malaga, Delphine Payros, Eva Meunier, Wafa Frigui et autres

The molecular factors and genetic adaptations that contributed to the emergence of Mycobacterium tuberculosis (MTB) from an environmental Mycobacterium canettii-like ancestor, remain poorly investigated. In MTB, the PhoPR two-component regulatory system controls production and secretion of proteins and lipid virulence effectors. Here, …

fr, es (code pays fourni par la source)