Lei Zhang

Determinants of MR Relaxation in the Extremely Preterm Brain at Adolescence: Myelin and Iron

Ryan McNaughton, Hua Ning, Lei Zhang, David W. Kennedy et autres

Purpose: To describe the dependencies of multiparametric quantitative MRI (MP-qMRI) on myelin and iron content in the extremely preterm born brain at adolescence. Methods: Algorithms for a fast exchange relaxation (FER) model and MP-qMRI create maps of R1, R2, myelin, and iron …

Oscillatory shear stress-mediated aberrant O-GlcNAc SIRT3 accelerates glycocalyx inflammatory injury via LKB1/p47phox/Hyal2 signaling

Lei Zhang, Jiajia Li, Jun Chen, Lei Jin et autres

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Astrocytes promote the proliferation of oligodendrocyte precursor cells through connexin 47-mediated LAMB2 secretion in exosomes

Nannan Cheng, Yuanfeng Xiong, Wenjin Zhang, Xiaohong Wu et autres

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Exercise more efficiently regulates the maturation of newborn neurons and synaptic plasticity than fluoxetine in a CUS-induced depression mouse model

Xin Liang, Jing Tang, Ying-qiang Qi, Yanmin Luo et autres

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Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Lei Jin, Peng Xiang, Shengmei Zeng, Le Chen et autres

Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive. Vascular glycocalyx coating on the endothelium would be damaged and caused endothelial dysfunction in the inflammatory microenvironment, which …

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Self-Assembling Porphyrins as a Single Therapeutic Agent for Synergistic Cancer Therapy: A One Stone Three Birds Strategy

Jun Chen, Feng Chen, Lei Zhang, Zhangyou Yang et autres

Combining photodynamic therapy (PDT), chemodynamic therapy (CDT), and ferroptosis is a valuable means for an enhanced anticancer effect. However, traditional combination of PDT/CDT/ferroptosis faces several hurdles, including excess glutathione (GSH) neutralization and preparation complexity. In this work, a versatile multifunctional nanoparticle (HCNP) …

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Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model

Lei Zhang, Xiang He, Ying Xiong, Ran Qin et autres

BACKGROUND: Epidemiologic evidence suggests that PM2.5 exposure aggravates asthma, but the molecular mechanisms are not fully discovered. METHODS: Ovalbumin (OVA)-induced mice exposed to PM2.5 were constructed. Pathological staining and immunofluorescence were performed in in vivo study. Gene set enrichment analysis (GSEA) was …

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AMPK/mTOR downregulated autophagy enhances aberrant endometrial decidualization in folate‐deficient pregnant mice

Yan Zhang, Rufei Gao, Lei Zhang, Yanqing Geng et autres

Existing evidence suggests that adverse pregnancy outcomes are closely related to dietary factors. Folate plays an important role in neural tube formation and fetal growth, folate deficiency is a major risk factor of birth defects. Our early studies showed that folate deficiency …

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PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model

Xiang He, Lei Zhang, Ran Qin, Junyi Wang et autres

BACKGROUND: Particulate matter of 2.5 µm or less in diameter (PM2.5) is one of the most complex pollutants in the atmospheric environment and harmful to human health. Epidemiologic evidence suggests that asthma exacerbation is associated with PM2.5 exposure. However, the molecular mechanism …

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Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats

Lin Chen, Feng‐lei Chao, Wei Lü, Lei Zhang et autres

Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise …

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Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin β4-mediated cell adhesion

Wenjin Zhang, Xiaoyan Zhang, Lei Zhang, Dan Xu et autres

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AMPK/mTOR down-regulated autophagy enhances aberrant endometrial decidualization in folate deficient pregnant mice

Yan Zhang, Rufei Gao, Lei Zhang, Yanqing Geng et autres

Supplementary Methods: 1 Mouse endometrial stromal cell isolation and culture; 2. Immunofluorescence cytology. 2. Supplementary Figures: Figure S1. The serum folate concentration was detected by electro-chemiluminescence immunoassay; Figure S2. Cell indentification was induced by hormone treatment in primary mESCs (in vitro); Figure …

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