Claudia Bearzi

Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

BACKGROUND: Metastatic recurrence represents the major clinical challenge in early-stage lung cancer after curative surgery. Here, we investigated the role of circulating extracellular vesicles and particles (EVPs) in promoting formation of pre-metastatic niches (PMNs). METHODS: Plasma-derived EVPs were obtained by ultracentrifugation from …

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Additional file 3 of Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Supplementary Material 3.

it, cz, pl, se (code pays fourni par la source)

Additional file 1 of Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Supplementary Material 1.

it, cz, pl, se (code pays fourni par la source)

Additional file 2 of Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Supplementary Material 2.

it, cz, pl, se (code pays fourni par la source)

Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Abstract Background Metastatic recurrence represents the major clinical challenge in early-stage lung cancer after curative surgery. Here, we investigated the role of circulating extracellular vesicles and particles (EVPs) in promoting formation of pre-metastatic niches (PMNs). Methods Plasma-derived EVPs were obtained by ultracentrifugation …

it, cz, pl, se (code pays fourni par la source)

Additional file 1 of Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Supplementary Material 1.

it, cz, pl, se (code pays fourni par la source)

Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Abstract Background Metastatic recurrence represents the major clinical challenge in early-stage lung cancer after curative surgery. Here, we investigated the role of circulating extracellular vesicles and particles (EVPs) in promoting formation of pre-metastatic niches (PMNs). Methods Plasma-derived EVPs were obtained by ultracentrifugation …

it, cz, pl, se (code pays fourni par la source)

Additional file 2 of Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Supplementary Material 2.

it, cz, pl, se (code pays fourni par la source)

Additional file 3 of Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

Francesca Pontis, Patrizia Ghidotti, Nicole Ferrario, Camilla Locatelli et autres

Supplementary Material 3.

it, cz, pl, se (code pays fourni par la source)

Modulation of L-Type Calcium Currents by Resveratrol-Induced Myogenesis in C2C12 Cells

Andrea Biagini, Luana Sallicandro, Jasmine Covarelli, Rosaria Gentile et autres

Skeletal muscle differentiation is tightly regulated by membrane potential dynamics and voltage-dependent ion channel activity. Potassium (K+) and calcium (Ca2+) currents cooperate to orchestrate the transition of myoblasts into fusion-competent myotubes, and alterations in this process are associated with dystrophic phenotypes. Here, …

it, al (code pays fourni par la source)

Polyethylene nano- and microplastics trigger metabolic stress responses in human vaginal epithelial cells

Paola Pontecorvi, Matteo Cassandri, Alessandra Gianoncelli, Lorella Pascolo et autres

Nano- and microplastics (N/MPs) are emerging environmental contaminants increasingly detected in multiple human tissues, yet their biological effects remain poorly defined. The vaginal epithelium represents a relevant but largely unexplored site of exposure. Here, we investigated the metabolic and elemental responses of …

it (code pays fourni par la source)

Photonic Immunosorbent Assay PHISA for specific detection of label-free biomolecules

Maria Grazia Ceraolo, Stefano Ferretti, Silvia Gentilini, Angela Capocefalo et autres

Detecting small amounts of specific biomolecules with high precision is a cornerstone of environmental monitoring, medical diagnostics, and biochemical research. Consolidated biochemical immunoassays offer established protocols and high reliability but suffer from complex procedures, expensive reagents, invasive labeling, and prolonged timescales. We …