Sonja Häckel

AO Spine Clinical Practice Recommendations: When to Operate in Lumbar Disc Herniation

Gianluca Vadalà, Luca Ambrosio, Xiaolong Chen, Juan Pablo Cabrera et autres

Study Design Literature review with consensus clinical recommendations. Objective To review key studies on surgical vs. non-operative treatment for lumbar disc herniation (LDH) and present recommendations for how the practicing clinician should use this evidence. Methods Two randomized controlled trials (RCTs), two …

it, cn, cl, us, au, cz, in, ru, de, hk, Égypte, sa, ch, hr, gb, se, kr, ca (code pays fourni par la source)

Mentoring Experiences, Perceived Availability, and Preferred Topics Among Respondents to an Open Survey of Medical Students and Physicians in Switzerland

Julia Alessandra Holtmann, Jan-Friso Beck, Julia Hegy, Moritz Tannast et autres

Background/Objectives: Mentoring may support professional development in medicine, but experiences and perceived programme availability may differ across career stages. We aimed to describe previous mentoring participation, perceived availability, satisfaction, preferred topics and formats, and responses to a generic digital facilitation item among …

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Publicly Accessible Large Language Model Responses to Frequently Asked Questions About Spondylodiscitis: Preliminary Expert Evaluation

Melanie Schindler, David Schiffelholz, Siegmund Lang, Josina Straub et autres

Background: Patients increasingly use large language models (LLMs) to obtain medical information, but the quality of LLM-generated information on complex spinal infections such as spondylodiscitis remains uncertain. Existing evaluations in spine surgery have mainly addressed degenerative conditions or surgical procedures, and disease-specific …

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Publicly Accessible Large Language Model Responses to Frequently Asked Questions About Spondylodiscitis: Preliminary Expert Evaluation.

Melanie Ardelt, David Schiffelholz, Siegmund Lang, Josina Straub et autres

Background Patients increasingly use large language models (LLMs) to obtain medical information, but the quality of LLM-generated information on complex spinal infections such as spondylodiscitis remains uncertain. Existing evaluations in spine surgery have mainly addressed degenerative conditions or surgical procedures, and disease-specific …

The pararectus approach is a complementary option for lower lumbar vertebral body replacement: Clinical feasibility and anatomical considerations.

Christian Tinner, Julian Nachtsheim, Philipp Störrle, Sonja Häckel et autres

Purpose Lumbar vertebral body replacement (VBR) is indicated in unstable lumbar fractures with anterior column compromise but is technically demanding at the L4-L5 level due to high iliac crest position, large psoas muscle mass, and complex vascular anatomy. These factors may limit …

at (code pays fourni par la source)

The pararectus approach is a complementary option for lower lumbar vertebral body replacement: Clinical feasibility and anatomical considerations

Christian Tinner, Julian Nachtsheim, Philipp Störrle, Sonja Häckel et autres

PURPOSE: Lumbar vertebral body replacement (VBR) is indicated in unstable lumbar fractures with anterior column compromise but is technically demanding at the L4-L5 level due to high iliac crest position, large psoas muscle mass, and complex vascular anatomy. These factors may limit …

ch (code pays fourni par la source)

Unklare intradurale Läsion der Lendenwirbelsäule – Diagnostische und therapeutische Herausforderungen bei Redundant Nerve Roots

Philipp Störrle, Ralph T. Schär, Eike Immo Piechowiak, Christoph E. Albers et autres

Zusammenfassung Intradural gelegene Läsionen der Lendenwirbelsäule stellen insbesondere bei Patienten mit vorangegangenen Wirbelsäulenoperationen eine diagnostische Herausforderung dar. MRT-Befunde können neoplastische oder entzündliche Prozesse imitieren, wodurch die Abgrenzung zwischen tatsächlicher Pathologie und postoperativen Veränderungen erschwert wird. Ein 63-jähriger Mann stellte sich 6 Jahre …

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Modulation of ossification and inflammatory pathways during dexamethasone-induced in vitro osteogenesis

Antoine Buetti‐Dinh, Claudia Siverino, Jorge Ubeda Garrido, Carmen Lanzillotti et autres

Abstract Background Dexamethasone (DEX) is used in vitro to promote osteogenic differentiation of human bone marrow mesenchymal stromal cells (hBMSCs). In clinical use, however, glucocorticoids induce osteoblast and osteocyte apoptosis while increasing osteoclast survival, leading overall to osteoporosis and high fracture risk. …

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Dexamethasone-induced PPARG expression in osteogenic differentiation in vitro: impact on SOX9 and RUNX2 levels

Maria Rosa Iaquinta, Carmen Lanzillotti, Mauro G. Tognon, Fernanda Martini et autres

ABSTRACT Background The effects of dexamethasone during in vitro human osteogenesis present a complex picture. On one side, dexamethasone promotes the osteogenic differentiation of human bone marrow mesenchymal stromal cells (BMSCs) by downregulating SOX9 . On the other side, it simultaneously promotes …

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Therapeutic Approaches for Enhancing Spinal Fusion in Low Back Pain: A Review With a Focus on the Elderly

Shuimu Chen, Zhen Li, Sebastian Frederick Bigdon, Sonja Häckel et autres

Background: Low back pain (LBP) is a prevalent cause of disability worldwide, particularly among the elderly, with degenerative spinal conditions often necessitating surgical intervention. Spinal fusion remains a definitive treatment for patients unresponsive to conservative therapies, yet its success is challenged by …

ch (code pays fourni par la source)

Impact of back protectors on spinal injuries in alpine winter sports: a retrospective cohort study

Christian Tinner, Niklas Rutsch, A Ackermann, Sonja Häckel et autres

PURPOSE: This retrospective cohort study investigated whether back protectors reduce the incidence and severity of spinal injuries in alpine winter sports, hypothesizing they may affect the type, location, and severity rather than fully prevent them. METHODS: We retrospectively identified patients with alpine …

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Single-Stage Versus Two-Stage 360° Stabilization Procedure in Unstable Thoracolumbar Burst Fractures – A Retrospective Quasi-Experimental Analysis

Christian Tinner, Sonja Häckel, Chiara Geismar, Samuel Schaible et autres

Study Design Retrospective quasi-experimental study conducted at two Level I trauma centers over a 6-year-period. Objectives Unstable thoracolumbar burst fractures are frequently treated by circumferential (360°) stabilization. Due to ongoing debate, this study aimed to compare whether single- or two-stage 360° stabilization …

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