Fraser Morton

Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge

Julie C. Worrell, Kerrie E Hargrave, George Finney, Chris Hansell et autres

Lung structural cells form barriers against pathogens and trigger immune responses following infections. This leads to the recruitment of innate and adaptive immune cells some of which remain within the lung and contribute to enhanced pathogen control following subsequent infections. There is …

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POS1366 INTEROBSERVER VARIABILITY IN SYNOVIAL TISSUE BIOPSY MARKERS: RESULTS FROM OMERACT SPECIAL INTEREST GROUP ON SYNOVIAL TISSUE BIOPSY

Mario Ferraioli, S. Alivernini, João Eurico Fonseca, Søren Andreas Just et autres

Background: Analysis of synovial tissue biopsy (STB) has emerged as a promising tool in Rheumatoid Arthritis (RA) research, considering that synovium is the main target of inflammatory arthritis. In particular, STB can play a pivotal role in the quest to predict treatment …

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ABS0252 PREVALENCE OF IFN HIGH RHEUMATOID ARTHRITIS IN EARLY AND ESTABLISHED RA PATIENTS

Eszter Csomor, Lygia Stewart, Fraser Morton, Carolyn Paterson et autres

Background: A pathogenic role for type I interferons (IFN) has been hypothesized across multiple autoimmune indications, including rheumatoid arthritis (RA). Evidence in the literature shows that an elevated type I IFN gene signature (IFNGS) is present in the peripheral blood and synovial …

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RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study

William Haese-Hill, Fraser Morton, Carl S. Goodyear, Duncan Porter et autres

BACKGROUND: Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, despite its potential, gene expression analysis remains challenging for clinicians due to the specialised skills …

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Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis

Tineke J van Wesemael, Fraser Morton, Judith W Heutz, M. Maurits et autres

BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies against modified proteins, known as anti-modified protein autoantibodies (AMPAs). While the relationship between different AMPA isotypes and various risk factors remains poorly understood, investigating this association is important …

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RNAcare: Integrating Clinical Data with Transcriptomic Evidence using Rheumatoid Arthritis as a Case Study

William Haese-Hill, Fraser Morton, Carl S. Goodyear, Duncan Porter et autres

ABSTRACT Background Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, despite its potential, gene expression analysis remains challenging for clinicians due to the specialised …

gb, fr (code pays fourni par la source)

Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge

Julie C. Worrell, Kerrie E Hargrave, George Finney, Chris Hansell et autres

Abstract Lung structural cells, including epithelial cells and fibroblasts, form barriers against pathogens and trigger immune responses following infections such as influenza A virus. This response leads to the recruitment of innate and adaptive immune cells required for viral clearance. Some of …

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OP0033 FIBROBLAST GENE, FKBP7 INDUCED BY Ca2+ DEPENDENT ER STRESS ASSOCIATED WITH CLINICAL OUTCOME IN RHEUMATOID ARTHRITIS AND CROHN’S DISEASE; MULTI-CENTRE GWAS AND FUNCTIONAL STUDIES

M. Maurits, A. Cameron, Scott A. Jelinsky, S. Blüml et autres

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Time-varying risks of infection in patients as they proceed through the phases of ‘pre-RA’: results from the Scottish Early RA inception cohort

Duncan Porter, Sahil Jain, Evelyn Qian, Fraser Morton et autres

ObjectiveRheumatoid arthritis (RA) develops after progressing through sequential 'pre-RA' phases. The mechanisms driving progression from one phase to the next remain poorly understood. This study examined the longitudinal rates of community and hospital infections in patients during sequential stages of pre-RA and …

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Lung stromal cell dynamics are altered by infection experience and ongoing antigen presentation following influenza re-challenge

Julie C. Worrell, Kerrie E Hargrave, George Finney, Chris Hansell et autres

Stromal cells can be permanently altered by insults, a process termed trained immunity. Whether these cells contribute to protection or pathology in infections such as influenza a virus (IAV) is unclear. We hypothesise that trained stromal cells may participate in protective immunity …

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Classification of long-term condition patterns in rheumatoid arthritis and associations with adverse health events: a UK Biobank cohort study

Philip McLoone, Bhautesh Jani, Stefan Siebert, Fraser Morton et autres

Purpose: We aimed to classify individuals with RA and ≥2 additional long-term conditions (LTCs) and describe the association between different LTC classes, number of LTCs and adverse health outcomes. Methods: We used UK Biobank participants who reported RA (n=5,625) and employed latent …

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Association between risk, duration and cause of hospitalisations in people with rheumatoid arthritis and multimorbidity in the UK Biobank and Scottish Early Rheumatoid Arthritis (SERA) cohorts: Longitudinal observational study

Fraser Morton, Bhautesh Jani, Frances S Mair, Philip McLoone et autres

OBJECTIVES: To investigate association between presence of multimorbidity in people with established and early rheumatoid arthritis (RA) and risk, duration and cause of hospitalisations. DESIGN: Longitudinal observational study. SETTING: UK Biobank, population-based cohort recruited between 2006 and 2010, and the Scottish Early …

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