Carolyn Paterson

ABS0252 PREVALENCE OF IFN HIGH RHEUMATOID ARTHRITIS IN EARLY AND ESTABLISHED RA PATIENTS

Eszter Csomor, Lygia Stewart, Fraser Morton, Carolyn Paterson et autres

Background: A pathogenic role for type I interferons (IFN) has been hypothesized across multiple autoimmune indications, including rheumatoid arthritis (RA). Evidence in the literature shows that an elevated type I IFN gene signature (IFNGS) is present in the peripheral blood and synovial …

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Occupational skin dose from radionuclide contamination: one country’s approach at standardising skin dose estimates using Varskin+

Katherine Sharpe, Stephen McCallum, Janice O’Neill, Carolyn Paterson et autres

Abstract The manipulation of unsealed radiopharmaceuticals by healthcare workers can cause accidental personal contamination leading to occupational radiation skin dose. The UK Ionising Radiations Regulations 2017 require that potential skin doses arising from reasonably foreseeable accident scenarios are included in risk assessments. …

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Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography

K.A. Jones, Carolyn Paterson, Stuart C. Ray, D. W. Motherwell et autres

BACKGROUND: Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel …

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Optimising approximate entropy for assessing cardiac dyssynchrony with radionuclide ventriculography

K.A. Jones, Carolyn Paterson, D. Hamilton, A.D. Small et autres

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Radionuclide ventriculography phase analysis for risk stratification of patients undergoing cardiotoxic cancer therapy

K.A. Jones, A.D. Small, Surajit Ray, D. Hamilton et autres

BACKGROUND: Accurate diagnostic tools to identify patients at risk of cancer therapy-related cardiac dysfunction (CTRCD) are critical. For patients undergoing cardiotoxic cancer therapy, ejection fraction assessment using radionuclide ventriculography (RNVG) is commonly used for serial assessment of left ventricular (LV) function. METHODS: …

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Biodistribution and radiation dosimetry of Flutemetamol (18F) injection in Japanese healthy volunteers

Michio Senda, Mitsuru Sasaki, Keita Fujikawa, Carolyn Paterson et autres

1510 Objectives Flutemetamol (18F) Injection is a radiopharmaceutical under development by GE Healthcare for amyloid plaque detection. The biodistribution and radiation dosimetry profiles of this radiopharmaceutical have been assessed in Japanese healthy volunteers (HVs). Methods The biodistribution of 18F following the intravenous …

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Quantitative analysis shows that contrast medium in positron emission tomography/computed tomography may cause significant artefacts

Clare McKeown, Mary-Frances Dempsey, Anthony J. Gill, Carolyn Paterson

OBJECTIVES: Attenuation correction algorithms are required for accurate quantification of PET data and for mapping of radioactive tracers. Modern PET systems incorporate computed tomography (CT) systems to perform attenuation correction. However, high-density media, such as contrast agents, may introduce potentially clinically significant …

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Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study

Jonathan Cavanagh, Carolyn Paterson, John McLean, Sally L. Pimlott et autres

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Radionuclide imaging of the renal tract: principles and applications

E. Kalkman, Carolyn Paterson

Radionuclide imaging remains crucial in the evaluation of the renal tract by providing functional information that cannot be obtained by CT, MRI or ultrasound. Static renography with 99mTc-DMSA is extremely useful in providing an accurate quantification of viable renal parenchyma. Dynamic renography …

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Changes in the Doppler waveform of the ovine femoral artery following infusion of vasoactive agents: a preliminary study

Patricia Pawson, A. Nolan, Joanne Reid, J.S. Boyd et autres

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Aortic body chemodectoma causing pulmonary oedema in a cat

Ruth Willis, Alun Williams, Tobias Schwarz, Carolyn Paterson et autres

A seven-year-old male domestic shorthaired cat was presented with persistent dyspnoea. Thoracic radiography and echocardiography revealed pulmonary oedema and a mass at the base of the heart. At necropsy the mass was found to be an aortic body chemodectoma that had metastasised …

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