Hans Peter Larsson

Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia

Jessica J. Jowais, Laura M. Castro-González, Alessia Golluscio, D. Peter Tieleman et autres

BACKGROUND AND PURPOSE: 7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT …

us, ca, se (code pays fourni par la source)

A mechanistic understanding of how KCNE1 tunes KCNQ1 channel pharmacology

Yahnell Judah, Jessica J. Jowais, Valentina Corradi, Marta Elena Perez et autres

The IKs potassium channel that is essential for cardiac repolarization is formed by KCNQ1 and KCNE1 subunits. Promising activators of KCNQ1 need to affect KCNQ1-KCNE1 to be used as therapeutics to prevent cardiac arrythmia. Unfortunately, KCNE1 dramatically impairs several KCNQ1 activators. How …

us, ca, se (code pays fourni par la source)

KCNQ1 and PIP2: it takes two to tango

Alicia de la Cruz, Hans Peter Larsson

se (code pays fourni par la source)

Beneficial action potential duration–shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2

Julien Louradour, Tibor Hornyik, Alicia de la Cruz, Irene Hiniesto‐Iñigo et autres

AIMS: Loss-of-function mutations in KCNQ1 and KCNH2 (α-subunits of the slow delayed IKs and rapid delayed IKr-conducting repolarising K+ channels) lead to long QT syndrome type 1 (LQT1) and 2 (LQT2), respectively. These channelopathies present with longer action potential duration (APD) and …

ch, hu, de, se, us (code pays fourni par la source)

(Invited) Mechanistic Understanding of Aqueous Photo(electro)Catalytic CO2 Reduction

Hans Peter Larsson, Hanna Härelind

Visible light-driven catalytic reduction of CO2 into fuels is a worthy goal in the pursuit of solar energy storage or carbon capture. However, materials that are capable of selective photocatalytic conversion of CO2 within a fully aqueous solvent usually consist of rare …

Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia

Pia Dahlberg, Serena Pozzi, Linda Bulmer, Alessia Golluscio et autres

The present study aimed to characterize the SCN5A variant I1333V, found in five families with a history of suspected catecholaminergic polymorphic ventricular tachycardia (CPVT). SCN5A encodes the pore-forming subunit of the cardiac voltage-gated sodium channel Na V 1.5. Gain of SCN5A function …

se (code pays fourni par la source)

Rescue of loss‐of‐function long QT syndrome‐associated mutations in KV7.1/KCNE1 by the endocannabinoid N‐arachidonoyl‐L‐serine (ARA‐S)

Irene Hiniesto‐Iñigo, Akshay Sridhar, Julien Louradour, Alicia de la Cruz et autres

Abstract Background and Purpose Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding KV7.1/KCNE1 are the most frequent, with channel loss‐of‐function …

se, ch, it (code pays fourni par la source)

Catecholamine-Induced Inflammasome Activation in the Heart Following Photothrombotic Stroke

Xavier O. Scott, Nadine A. Kerr, Juliana Sanchez‐Molano, Juan Pablo de Rivero Vaccari et autres

Cerebrovascular stroke patients exhibit an increased incidence of cardiac arrhythmias. The pathomechanisms underlying post-traumatic cardiac dysfunction include a surge of catecholamines and an increased systemic inflammatory response, but whether inflammasome activation contributes to cardiac dysfunction remains unexplored. Here, we used a mouse …

us, se (code pays fourni par la source)

Author response: PUFA stabilizes a conductive state of the selectivity filter in IKs channels

Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta Elena Perez et autres

Travelling through the heart are waves of electrical activity that cause muscle cells to contract and pump blood around the body. The waves are generated by charged ions which flow via tiny channels in and out of the muscle cells. This electrical …

us, ca, gb (code pays fourni par la source)

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta Elena Perez et autres

In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolonged QT interval on the ECG, which increases …

se, us, ca, gb (code pays fourni par la source)

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta E. Perez-Rodriguez et autres

Abstract In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause Long QT Syndrome (LQTS), a syndrome with a prolonged QT interval on the ECG, which …

se, us, ca, gb (code pays fourni par la source)

Author response: PUFA stabilizes a conductive state of the selectivity filter in IKs channels

Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta E. Perez-Rodriguez et autres

In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause Long QT Syndrome (LQTS), a syndrome with a prolonged QT interval on the ECG, which increases …

us, ca (code pays fourni par la source)