Morgan Black

Abstract 3085: Molecular characterization of inhibition of the DNA repair protein RAD51 by the small molecule JKYN-1

Peter Ferguson, Mark David Vincent, Yousef Najajreh, Morgan Black et autres

Abstract The ability of cancer cells to form large tumors and rapidly adapt to changing environmental conditions results from inherent genetic instability that also confers upon them sensitivity to cytotoxic agents. Cancer cells rely heavily on the action of the protein RAD51, …

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Abstract 3098: Discovery of the RAD51 inhibitor JKYN-1 and characterization of its anticancer activity in preclinical models of non-small cell lung cancer

Yifan Yu, Morgan Black, Nikolina Radulovich, Peter Ferguson et autres

Abstract BACKGROUND: RAD51 is a recombinase that plays a central role in homologous recombination-mediated double-strand DNA break repair and is required for the maintenance of genome stability. In addition to this canonical function, RAD51 contributes to the tolerance of replication stress, a …

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Circulating tumor DNA as part of the routine work-up for patients with suspected advanced lung cancer

Emma J.B. Holjak, Tia Brasoveanu, Saurav Verma, Saqib Raza Khan et autres

Liquid biopsy (LB) is a useful tool in patients with advanced non-small cell lung cancer (aNSCLC) to detect actionable molecular alterations and thereby allow genotype-matched therapies. Currently, LB is recommended for individuals diagnosed with aNSCLC who have an insufficient tissue sample or …

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Inhibitors of RAD51 as potential novel therapies in Acute Myeloid Leukemia

Mick Bhatia, Peter L. Ferguson, Anargyros Xenocostas, James D. Koropatnick et autres

Abstract RAD51 is a highly conserved gene whose protein product, RAD51, is instrumental in the maintenance of genome integrity in eukaryotes. RAD51 is well known to function in homologous recombination repair ('HRR') in conjunction with the BRCA1 and BRCA2 gene products. It …

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Extended Survival with Pancreatic Carcinosarcoma: A Case Report and Literature Review

Tian Xiao, Claire Browne, Morgan Black, Celia E. Marginean et autres

Pancreatic carcinosarcoma is a rare and aggressive malignancy that can mimic pancreatic adenocarcinomas in presentation but often has different disease biology and different responses to conventional treatment for pancreatic adenocarcinoma. Case reports have documented a 5-year overall survival of approximately 13% only …

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Abstract 4289: Discovery of potent RAD51 inhibitors with anticancer activity in preclinical models of non-small cell lung cancer

Yifan Yu, Morgan Black, Nikolina Radulovich, Peter L. Ferguson et autres

RAD51 is a protein that plays a key, canonical role in double-strand break (DSB) repair through homologous recombination (HR) and is biologically important for maintaining genome stability. Given its additional, non-canonical role in mitigating the replication stress characteristic of tumor cells, RAD51 …

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Treatment Patterns of Pancreatic Neuroendocrine Tumor (pNET) Patients at Two Canadian Cancer Centres

Gautham P. Nair, Morgan Black, Kathie Baer, Stephen A. Welch et autres

Pancreatic neuroendocrine tumors (pNETs) are rare but increasingly prevalent malignancies with varied prognoses and a diverse range of treatment options, including surgery, somatostatin analogues (SSAs), chemotherapy, targeted therapy, and peptide receptor radionuclide therapy (PRRT). This retrospective cohort study analyzed treatment patterns among …

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Circulating tumor DNA as part of the routine work-up for patients with suspected advanced lung cancer

Tia Brasoveanu, Emma J.B. Holjak, Saurav Verma, Saqib Raza Khan et autres

Introduction: Liquid biopsy is a useful tool in patients with advanced NSCLC (aNSCLC) with insufficient tumor samples to detect molecular alterations and thereby allow genotype-matched therapies. However, despite the potential advantages of liquid biopsy, its incorporation into the standard early work-up for …

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Detection of circulating tumor DNA after stereotactic ablative radiotherapy in patients with unbiopsied lung tumors (SABR-Detect)

Saurav Verma, Sympascho Young, Thomas A. C. Kennedy, Morgan Black et autres

Introduction: Definitive stereotactic ablative radiotherapy (SABR) is a standard approach in patients with stage I/IIA non–small-cell lung cancer (NSCLC) who are not candidates for surgery. Patients with inaccessible tumors or at high risk of complications from biopsy are sometimes treated without a …

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Clinical Outcome Patterns of Use of Radium-223 in Patients with Metastatic Castration-Resistant Prostate Cancer

Jasna E. Deluce, Morgan Black, Emma K.L. Churchman, Eric Winquist et autres

Introduction: Radium-223 dichloride (radium-223) is a bone-targeting radioisotope therapy that aids in the survival of patients with metastatic castration-resistant prostate cancer (mCRPC) to bones. This study aimed to describe the clinical characteristics and outcomes of patients with mCRPC treated with radium-223 in …

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EP.07H.01 Analysis of Variables Predicting pCR and irAEs in Resectable NSCLC Receiving Neoadjuvant Immunotherapy with Chemotherapy (Pre-PLaN)

Santosh Kumar Verma, Daniel Breadner, R. Nayak, Morgan Black et autres

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Impact of an Etoposide Chemotherapy Shortage on Patients With Extensive-Stage Small-Cell Lung Cancer: Results of a Natural Experiment

Claire Browne, T. J. Ayoub, Nadeesha Samarasinghe, S. M. Qasim Hussaini et autres

PURPOSE A shortage of essential intravenous (IV) etoposide lasted from 2018 until 2020 in Ontario, Canada, allowing for a natural experiment in which external factors (IV etoposide availability) dictated patients' treatment assignment. The purpose of this study was to evaluate the impact …

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