Anargyros Xenocostas

Concurrent Mold, Mycobacterial, and Viral Infections in a Hematopoietic Stem Cell Transplant Recipient Undergoing Lung Transplantation for Graft-Versus-Host Disease

Layan Akkielah, Wayne Leung, Serena Wang, Lili Ataie et autres

Hematopoietic stem cell transplant (HSCT) recipients are at high risk for opportunistic infections due to profound immunosuppression and graft-versus-host disease (GvHD). Molds and nontuberculous mycobacteria (NTM) pose diagnostic and therapeutic challenges, especially when infections overlap. A 42-year-old woman with prior allogeneic HSCT …

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Discovery and validation of islet regenerative proteins secreted by human multipotent stromal cells

Xin Xie, Nouran N. Al-Banaa, Yina Tian, Gillian I. Bell et autres

INTRODUCTION: Diabetes affects >500 million people worldwide. Despite insulin therapy, most patients develop devastating complications, emphasizing the need for curative strategies. Human multipotent stromal/stem cells (MSC) secrete factors that promote islet regeneration. We previously showed that intrapancreatic (iPan) delivery of Wnt-activated MSC-conditioned …

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Streamlining Apheresis: A Dual-Intervention Quality Improvement Initiative to Increase the Efficiency in Stem Cell Collection

Renee Dickey, Sue Sinclair, Karla Schebesch, Ivy E. Verriet et autres

Introduction Autologous stem cell transplantation (ASCT) requires efficient collection of peripheral blood stem cells. At London Health Sciences Centre (LHSC), patients are routinely booked for three-day apheresis collections leading to resource inefficiencies. Each extra day impacts patients, apheresis costs, staffing, and resources. …

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Enhancing Recovery in Autologous Stem Cell Transplantation: The Impact of Filgrastim Prophylaxis in a Risk-Adapted Protocol

Dr. Uday Deotare, James Heitzner, Adrienne Fulford, Shona A Philip et autres

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Obesity Dosing of High Dose Melphalan in Patients with Multiple Myeloma Undergoing Autologous Hematopoietic Cell Transplant

Deanna Caldwell, Morgan Hopkins, Kate Kelly, Adrienne Fulford et autres

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Acquired Amegakaryocytic Thrombocytopenia With Evolution Toward Aplastic Anemia Treated With Thrombopoietin Receptor Agonists: A Case Report

Faramarz Jabbari-Zadeh, Mujtaba Basharat, Benjamin Chin-Yee, Chai W. Phua et autres

Amegakaryocytic thrombocytopenia is a rare hematological disorder that is characterized by absent or near-absent megakaryocytes without evidence of other hematological abnormalities. The disease can either be congenital or acquired. Given that less than a hundred cases of acquired amegakaryocytic thrombocytopenia (AAMT) have …

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Inhibitors of RAD51 as potential novel therapies in Acute Myeloid Leukemia

Mick Bhatia, Peter Ferguson, Anargyros Xenocostas, James Koropatnick et autres

Abstract RAD51 is a highly conserved gene whose protein product, RAD51, is instrumental in the maintenance of genome integrity in eukaryotes. RAD51 is well known to function in homologous recombination repair ('HRR') in conjunction with the BRCA1 and BRCA2 gene products. It …

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Streamlining Apheresis: A Dual‐Intervention Quality Improvement Initiative to Increase the Efficiency in Stem Cell Collection

Ivy E. Verriet, Renee Dickey, Sue Sinclair, Shona Philip et autres

ABSTRACT Autologous stem cell transplantation ( ASCT ) requires efficient collection of peripheral blood stem cells. At London Health Sciences Centre ( LHSC ), high‐risk multiple myeloma patients are routinely booked for three‐day apheresis collections to meet higher CD34 + cell count …

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Contribution of cytokeratin 19-expressing cells towards islet regeneration induced by multipotent stromal cell secreted proteins

Nazihah Rasiwala, Gillian I. Bell, Anargyros Xenocostas, David A. Hess

Residual beta cell function has been documented in "medalist" patients who have lived with Type 1 diabetes (T1D) for >50 years. In addition, endocrine cell neogenesis first occurs in the developing human embryo from progenitor cells derived from pancreatic ductal epithelial structure. …

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Medical and Nutritional Outcomes Are Similar Among Autologous Transplant Patients on Enteral Nutrition When Compared to Parenteral Nutrition. A Randomized Pilot Study

Janet Madill, Brenda Hartman, Heather Resvick, Cheryl Sigfrid et autres

Autologous hematopoietic stem cell transplantation (AHSCT) is the treatment for myeloma and lymphoma. posttreatment, significant nutritional and medical issues and malnutrition assessed by Subjective Global Assessment (SGA) arise. No established effective treatment for using either parenteral (PN) or enteral routes (EN) to …

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Evaluating the Role of Thrombopoietin Receptor Agonists in the Treatment of Acquired Amegakaryocytic Thrombocytopenia: A Case Report and Review of the Literature

Faramarz Jabbari-zadeh, Mujtaba Basharat, Benjamin Chin‐Yee, Chai W. Phua et autres

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How Early Is Too Early? Use of Lineage‐Specific Chimerism in Early Detection of Donor‐Derived Malignancy After Allogeneic Stem Cell Transplant: A Case Report

Victor Pope, Adrienne Fulford, Uday Deotare, Shona Philip et autres

Allogeneic stem cell transplant is critical for treatment of certain hematologic malignancies. However, it has significant risks including relapsed malignancy, infection, and graft versus host disease. Rarely, de novo malignancy can arise from donor cells. Chimerism analysis is used to monitor engraftment …

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