Colette Kanellopoulos‐Langevin

Modulation of Immune Responses by Different Factors Extracted from Placenta

Pierre Bobé, Christian Bleux, Colette Kanellopoulos‐Langevin

In this chapter, the authors present some of their data supporting the hypothesis that two distinct placental factors with opposite activities can modulate both antibody and cell-mediated responses in vivo. In both assays, a placental fraction (PF) of 40 kd has a …

Variations in Cellular Responses of Mouse T Cells to Adenosine-5′-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage

Hanaa Safya, Amine Mellouk, Julie Legrand, Sylvain M. Le Gall et autres

A previous report has shown that regulatory T cells (Treg) were markedly more sensitive to ATP than conventional T cells (Tconv). Another one has shown that Tregs and CD45RBlow Tconvs, but not CD45RBhigh Tconvs, displayed similar high sensitivity to ATP. We have …

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Immunology and pregnancy

Colette Kanellopoulos‐Langevin

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Leukocyte Population Dynamics and Detection of IL-9 as a Major Cytokine at the Mouse Fetal-Maternal Interface

Mohamed Habbeddine, Philippe Verbeke, Sonia Karaz, Pierre Bobé et autres

Despite much interest in the mechanisms regulating fetal-maternal interactions, information on leukocyte populations and major cytokines present in uterus and placenta remains fragmentary. This report presents a detailed and quantitative study of leukocyte populations at the mouse fetal-maternal interface, including a comparison …

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Penicillin Kills Chlamydia following the Fusion of Bacteria with Lysosomes and Prevents Genital Inflammatory Lesions in C. muridarum-Infected Mice

Maud Dumoux, Sylvain M. Le Gall, Mohamed Habbeddine, Christiane Delarbre et autres

The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an 'inclusion'. Alternative persistent intra-cellular forms can be induced in culture by diverse stimuli …

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CD1d-restricted NKT cells modulate placental and uterine leukocyte populations during chlamydial infection in mice

Mohamed Habbeddine, Philippe Verbeke, Christiane Delarbre, R Moutier et autres

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Prion Protein and Shadoo Are Involved in Overlapping Embryonic Pathways and Trophoblastic Development

Bruno Passet, Rachel Young, Samira Makhzami, Marthe Vilotte et autres

The potential requirement of either the Prion or Shadoo protein for early mouse embryogenesis was recently suggested. However, the current data did not allow to precise the developmental process that was affected in the absence of both proteins and that led to …

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PrP and Shadoo are required for trophoblastic development

Bruno Passet, Rachel Young, Jean Luc Vilotte, Samira Makhzami et autres

absent

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Transplantation Tolerance to a Single Noninherited MHC Class I Maternal Alloantigen Studied in a TCR-Transgenic Mouse Model

Yoshinobu Akiyama, Stéphane Caucheteux, Cécile Vernochet, Yoshiko Iwamoto et autres

The mechanisms underlying tolerance to noninherited maternal Ags (NIMA) are not fully understood. In this study, we designed a double-transgenic model in which all the offspring's CD8(+) T cells corresponded to a single clone recognizing the K(b) MHC class I protein. In …

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Heredity—Venturing Beyond Genetics

Marie-Christine Maurel, Colette Kanellopoulos‐Langevin

Our knowledge of heredity has recently undergone major upheaval. Heredity transmits considerably more than just genetic elements. First, the oocyte is full of maternal cytoplasmic components that subsequently are present in each new cell. Second, maternal cells can pass to the progeny, …

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Tolerance induction to self-MHC antigens in fetal and neonatal mouse B cells

Stéphane Caucheteux, Cécile Vernochet, Josiane Wantyghem, Marie‐Claude Gendron et autres

We have studied the mechanisms of tolerance induction to self-MHC antigens in mouse B cells during fetal development and the post-natal period. To monitor the fate of autoreactive B cell clones, we used the 3-83 micro delta B cell receptor (BCR)-transgenic (Tg) …

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Role of NKT cells in the placenta and uterus of pregnant mice infected by Chlamydia trachomatis (42.5)

Colette Kanellopoulos‐Langevin, Christiane Delarbre, Mohamed Habbeddine, Philippe Verbeke et autres

Abstract In order to study the role of maternal NKT cells against a Chlamydia infection during pregnancy, we have compared CD1d-deficient, C57Bl/6 (B6) mice to wild type controls, in the presence or absence of a Chlamydia infection. We have examined the expression …

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