Hanaa Safya

P2X7 purinergic receptor plays a critical role in maintaining T-cell homeostasis and preventing lupus pathogenesis

Amine Mellouk, Tom Hutteau-Hamel, Julie Legrand, Hanaa Safya et autres

The severe lymphoproliferative and lupus diseases developed by MRL/lprmice depend on interactions between the Faslprmutation and MRL genetic background. Thus, the Faslprmutation causes limited disease in C57BL/6 mice. We previously found that accumulating B220+CD4–CD8–double negative (DN) T cells in MRL/lprmice show defective …

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Variations in Cellular Responses of Mouse T Cells to Adenosine-5′-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage

Hanaa Safya, Amine Mellouk, Julie Legrand, Sylvain M. Le Gall et autres

A previous report has shown that regulatory T cells (Treg) were markedly more sensitive to ATP than conventional T cells (Tconv). Another one has shown that Tregs and CD45RBlow Tconvs, but not CD45RBhigh Tconvs, displayed similar high sensitivity to ATP. We have …

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P2X7 receptor promotes intestinal inflammation in chemically induced colitis and triggers death of mucosal regulatory T cells

Vanessa Ribeiro Figliuolo, Luiz Eduardo Baggio Savio, Hanaa Safya, Hayandra Ferreira Nanini et autres

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The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis

Aurore Besnard, Julien Gautherot, Boris Julien, Ali Tebbi et autres

UNLABELLED: Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH), to initiate growth, protect liver cells, and sustain remnant liver functions. Extracellular adenosine triphosphate rises in blood and bile after PH and contributes to liver regeneration, although purinergic receptors …

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Modulation of purinergic receptor P2X7-dependant activities during T lymphocyte activation

Hanaa Safya

L’ATP extracellulaire, à travers l’activation du récepteur P2X7, joue un rôle important dans l’immunité inné comme signal de danger responsable de l’assemblage de l’inflammasome, de la migration des cellules immunitaires et de la mort cellulaire. Bien que le rôle de la voie …

Modulation des activités du récepteur purinergique P2X7 au cours de l’activation des lymphocytes T

Hanaa Safya

L’ATP extracellulaire, à travers l’activation du récepteur P2X7, joue un rôle important dans l’immunité inné comme signal de danger responsable de l’assemblage de l’inflammasome, de la migration des cellules immunitaires et de la mort cellulaire. Bien que le rôle de la voie …

fr (code pays fourni par la source)

Modulation des activités du récepteur purinergique P2X7 au cours de l’activation des lymphocytes T

Hanaa Safya

Extracellular ATP through the receptor P2X7 (P2X7R) plays a key role in innate immunity as a danger signal that causes the activation of the inflammasome, enhancement of immune cell migration and cell death. Although the role of the ATP/P2X7R pathway in adaptative …

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P118 P2×4 IMPACTS BILIARY HOMEOSTASIS AND INFLAMMATORY RESPONSE AFTER PARTIAL HEPATECTOMY IN MICE

Aurélie Besnard, B Julien, Noémie Pean, Isabelle Garcin et autres

Loss of P2X7 Receptor Plasma Membrane Expression and Function in Pathogenic B220+ Double-Negative T Lymphocytes of Autoimmune MRL/lpr Mice

Sylvain M. Le Gall, Julie Legrand, Mohcine Benbijja, Hanaa Safya et autres

Lupus is a chronic inflammatory autoimmune disease influenced by multiple genetic loci including Fas Ligand (FasL) and P2X7 receptor (P2X7R). The Fas/Fas Ligand apoptotic pathway is critical for immune homeostasis and peripheral tolerance. Normal effector T lymphocytes up-regulate the transmembrane tyrosine phosphatase …

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