Determination of key functional structures of an amorphous VHL-based SMARCA2 PROTAC
Daria Torodii, Jacob B. Holmes, Manuel Cordova, Pinelopi Moutzouri et autres
3 citationsNature Communications
Fredrik Edfeldt
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20Publications signalées
545Citations signalées
4Affiliations récentes
Institutions déclarées
Domaines associés
Computational Drug Discovery MethodsProtein Structure and DynamicsMonoclonal and Polyclonal Antibodies ResearchProtein Kinase Regulation and GTPase SignalingInflammatory mediators and NSAID effects
Publications récentes
Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15–GFRaL–RET Complex Cell Signaling
Anaïs F. M. Noisier, Jenny Sandmark, Fredrik Edfeldt, Anna Backmark et autres
4 citationsJournal of Medicinal Chemistry
Rational discovery of molecular glues for the glucocorticoid receptor – 14-3-3 protein-protein interaction starting with application of traditional hit-finding methods
Matthew W. D. Perry, Claire C. Munier, João Augusto de Castro Neves, Anders Gunnarsson et autres
1 citationChemRxiv
The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity
Linda Öster, Marie Castaldo, Emma de Vries, Fredrik Edfeldt et autres
9 citationsJournal of Biological Chemistry
Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin
Frank Narjes, Fredrik Edfeldt, Jens Petersen, Linda Öster et autres
9 citationsJournal of Medicinal Chemistry
Comparison of the FMT assay with the Cell Painting approach in healthy patient derived fibroblasts
Tabea Hohensee, Fredrik Edfeldt
0 citationsBIO Web of Conferences
Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery
Benjamin C. Whitehurst, Matthias R. Bauer, Fredrik Edfeldt, Anders Gunnarsson et autres
13 citationsJournal of Medicinal Chemistry
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set
Simon C. C. Lucas, Ulf Börjesson, Mark J. Bostock, John Cuff et autres
13 citationsRSC Medicinal Chemistry
Interbase-FRET binding assay for pre-microRNAs
Mattias Bood, Anna Wypijewska del Nogal, Jesper R. Nilsson, Fredrik Edfeldt et autres
10 citationsScientific Reports
Fragment-Based Discovery of Novel Allosteric MEK1 Binders
Paolo Di Fruscia, Fredrik Edfeldt, Igor L. Shamovsky, Gavin W. Collie et autres
18 citationsACS Medicinal Chemistry Letters
Hot-Spotting with Thermal Scanning: A Ligand- and Structure-Independent Assessment of Target Ligandability
Molly Chilton, Benjamin Clennell, Fredrik Edfeldt, Stefan Geschwindner
20 citationsJournal of Medicinal Chemistry
Unified Software Solution for Efficient SPR Data Analysis in Drug Research
Göran Dahl, Stephan Steigele, Per Hillertz, Anna Tigerström et autres
10 citationsSLAS DISCOVERY
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