Leonardo Rigon

Dysfunctional mitophagy in Alzheimer's disease: evidence from peripheral optineurin

Simone Patergnani, Alessandro Trentini, Valentina Rosta, Paola Guindani et autres

Mitophagy and mitochondrial quality-control pathways are impaired in Alzheimer's disease (AD), but the relevance of peripheral mitophagy markers and their regulation during sustained amyloid-β (Aβ) stress remain unclear. We investigated whether serum optineurin, a mitophagy receptor, is altered in mild cognitive impairment …

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Different psychological and quality-of-life outcomes after subthalamic nucleus deep brain stimulation in Parkinson's disease patients: a prospective study

Marianna Mazza, Giuseppe Marano, Giorgio Veneziani, Francesco Maria Lisci et autres

BACKGROUND: The present study aimed to evaluate changes in hopelessness, psychological well-being, and quality of life following subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD). In addition, a secondary exploratory aim was to assess the role of anxiety …

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Where does excessive beta in Parkinson's disease originate? Insights from a case of unilateral cortico-pallidal pathway dysfunction

Leonardo Rigon, Valentina D’Onofrio, Laura Ludovica Grassi, Dario Ciprietti et autres

In Parkinson's Disease, a key feature is an exaggerated, oscillatory activity in the brain called the "beta rhythm", which occurs in the circuit, particularly relevant for motor functions, connecting the cortex (the outer brain layer) and the basal ganglia (the deeper structures). …

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Long-lasting concordance between imaging-guided and clinical-based STN-DBS programming enhances motor and axial outcomes in Parkinson's disease: A 3-year single-center study

Leonardo Rigon, Francesco Bove, A Lo Izzo, Nicola Montano et autres

IntroductionSubthalamic deep brain stimulation (STN-DBS) improves Parkinson's disease motor symptoms. Directional leads can extend the therapeutic window, despite further increasing programming complexity. Lead placement visualization software can facilitate STN-DBS programming, especially in contact selection process. We investigated the extent and impact on …

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Exploring Soil–Microbe Associations with Grapevine Nutrition in Tasmanian Pinot Noir Vineyards

Shunlei Li, Leonardo Rigon, Claudia Chiodi, Federico Gavinelli et autres

(1) Background: Soil nutrient availability in vineyards is shaped by physicochemical and biological processes. However, how baseline edaphic differences are related to soil microbial functional genes and plant elemental composition under biodynamic management remains unclear; (2) Methods: Two biodynamically managed Pinot Noir …

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Long-term response to deep brain stimulation of the globus pallidus internus in a patient of African origin with a homozygous DYT-AOPEP variant

Luca Lorenzon, Giulia Bonato, Sofia Pavan, Laura Ludovica Grassi et autres

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Deciphering macrophage molecular responses to Porphyromonas gingivalis outer membrane vesicles through combined immunoassay and Raman spectroscopic analyses

Yoshiyuki Matsuo, Aoi Son, Sara Gentile, Riccardo Bernola et autres

Outer membrane vesicles released by Porphyromonas gingivalis (Pg-OMVs) are emerging as critical mediators of periodontal and systemic pathology. Published literature has so far associated the presence of OMVs to an increased risk of cerebrovascular and neurodegenerative diseases, but the molecular-scale mechanisms underlying …

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Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson’s Disease: an exploratory study

Benjamin C. Tendler, Giulia Serafica, Serena Turchi, Davide Risato et autres

Parkinson's disease (PD) involves dopaminergic nigrostriatal pathways degeneration and early structural brain abnormalities, including iron accumulation in the substantia nigra (SN). Understanding how these neurodegenerative changes relate to functional network adaptations may clarify disease progression and symptom variability. We used a cross-sectional …

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Apple derived extracellular vesicles as positive modulators of glial inflammation and gut–brain axis signaling

Maria Pia Cavaleri, Luna Ardondi, Ilaria Vitali, Lucia Sileo et autres

Plant-derived extracellular vesicles (PDEVs) are emerging as bioactive dietary particles with the capacity to modulate mammalian physiology. Here, we characterize the structure and functional properties of apple-derived extracellular vesicles (ADEVs) and evaluate their relevance to neuroimmune and gut-brain communication. ADEVs exhibit canonical …

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Reporting of pre-analytical variables affecting the determination of brain-derived neurotrophic factor (BDNF) in patients with stroke: a scoping review

Elisa Bevilacqua, Luisa Cacciante, Francesca Burgio, Laura Danesin et autres

INTRODUCTION: Brain-derived neurotrophic factor (BDNF) is a neurotrophin expressed in the central nervous system, where it supports synaptic plasticity, neuronal survival, and dendritic remodeling. Reduced circulating BDNF levels have been reported in several neurological and psychiatric disorders, increasing evidence links BDNF to …

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Financial abilities in patients with Parkinson’s disease and mild cognitive impairment: unveiling cognitive and neurofunctional correlates of basic and advanced financial skills

Laura Danesin, Giulia Pagnin, Lorenza Maistrello, Giorgia Baron et autres

Background: Parkinson's disease (PD) entails widespread neurodegenerative changes extending beyond motor symptoms to cognitive and large-scale network alterations that compromise functional autonomy. Financial abilities (FAs) are complex, ecologically relevant skills crucial for independent living, yet their neurocognitive and neurofunctional substrates in PD …

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The importance of mitochondria and mitochondrial calcium signaling in health and disease: an updated outlook on inflammation

Giampaolo Morciano, Giulia Pellielo, Esther Densu Agyapong, Cristina Pellegrino et autres

BACKGROUND: Mitochondria are central regulators of cellular bioenergetics, calcium homeostasis and apoptosis. Beyond these classical roles, emerging evidence highlights their pivotal involvement in inflammation and related disease progression. Under physiological conditions, mitochondria sustain metabolism and signaling; however, when dysfunctional, they can release …

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