Hiroshi Fukasawa

Discovery of bispecific T-cell engagers targeting the non-mutated regions of mutant calreticulin for the treatment of myeloproliferative neoplasms

Yuya Nishimura, Kana Nakatani, Hiroshi Fukasawa, Ryota Uehara et autres

Abstract Introduction Calreticulin (CALR) is a chaperone protein found in the endoplasmic reticulum (ER). A +1 frameshift mutation in exon 9 of the CALR gene generates a novel C-terminal peptide that induces the pathogenesis of primary myelofibrosis (PMF) and essential thrombocythemia (ET). …

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Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure

Terukazu Kato, Keita Fukao, Takafumi Ohara, Noriyuki Naya et autres

Peroxisome proliferator-activated receptor δ (PPARδ) is considered to be a pharmaceutical target to treat metabolic diseases including atherosclerosis, but there is no PPARδ agonist available for clinical use. We have previously reported the discovery of piperidinyl/piperazinyl benzothiazole derivatives as a new series …

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Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists

Terukazu Kato, Takafumi Ohara, Naoyuki Suzuki, Noriyuki Naya et autres

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Coherent Neutral-pion and Eta-meson Photoproduction on the Deuteron

T. Ishikawa, Hisako Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

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Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method

Terukazu Kato, Takafumi Ohara, Naoyuki Suzuki, Susumu Muto et autres

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Resonance-like structure near the ηd threshold in the γd→π0ηd reaction

T. Ishikawa, H. Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

To investigate the interaction between the nucleon $N$ and nucleon resonance $N(1535)1/{2}^{\ensuremath{-}}$, the $\ensuremath{\eta}d$ threshold structure connected to the isoscalar $S$-wave $N\text{\ensuremath{-}}N(1535)1/{2}^{\ensuremath{-}}$ system has been experimentally studied in the $\ensuremath{\gamma}d\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}\ensuremath{\eta}d$ reaction at incident photon energies ranging from the reaction threshold to 1.15 …

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Resonance-like structure near the $\eta d$ threshold in the $\gamma{d}${$\to$}$\pi^0\eta{d}$ reaction

Takashi Ishikawa, H. Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

To investigate the interaction between the nucleon $N$ and nucleon resonance $N(1535)1/2^-$, the $\eta d$ threshold structure, connected to the isoscalar $S$-wave $N$-$N(1535)1/2^-$ system, has been experimentally studied in the $\gamma{d}${$\to$}$\pi^0\eta{d}$ reaction at incident photon energies ranging from the reaction threshold to …

ωN scattering length from ω photoproduction on the proton near the threshold

T. Ishikawa, H. Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

Photoproduction of the ω meson on the proton has been experimentally studied near the threshold. The total cross sections are determined at incident energies ranging from 1.09 to 1.15 GeV. The 1/2 and 3/2 spin-averaged scattering length aωp and effective range rωp …

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Measuring space-time structure of Δ(1232) resonance with the HBT correlations in double pion photoproduction around 1 GeV

Q. He, H. Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

Spatial-temporal properties of Δ(1232) resonance produced in double neutral pion photoproduction are investigated through HBT correlations of two identical pions. For this end, we develop a model in which the HBT correlations are measured in the reference frame of Δ at rest. …

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ωN scattering length from ω photoproduction on the proton near the reaction threshold

T. Ishikawa, H. Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

Photoproduction of the $\ensuremath{\omega}$ meson on the proton has been experimentally studied near the threshold. The total cross sections are determined at incident energies ranging from 1.09 to 1.15 GeV. The 1/2 and 3/2 spin-averaged scattering length ${a}_{\ensuremath{\omega}p}$ and effective range ${r}_{\ensuremath{\omega}p}$ …

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Study of Non-strange Dibaryon Resonances Via Coherent Double Neutral-Meson Photoproduction from the Deuteron

T. Ishikawa, H. Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

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ωN scattering length from ω photoproduction on the proton near the threshold

T. Ishikawa, Hisako Fujimura, Hiroshi Fukasawa, R. Hashimoto et autres

Although the ω meson is one of the best established hadrons, its fundamental properties such as the interaction with the nucleon is not known yet due to the difficulties in realizing scattering experiments. Recently, we have performed high-precision photoproduction experiment of the …

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