Haiwei Ni

Nanoplasmid PSMA DNA vaccine primes antitumor immunity and enhances response to PD-1 blockade against prostate cancer

Perry Ayn Mayson Maza, Leslie Flores, Dana Cyril-Ramirez, Praveen Neeli et autres

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Abstract 3544: Synergistic efficacy of a PSMA DNA vaccine and PD-1 inhibition in anti-tumor immunity against prostate cancer

Perry Ayn Mayson Maza, Dana Rae Cyril-Ramirez, Dafei Chai, Dan Zhao et autres

Abstract Prostate cancer (PCa) remains one of the leading causes of cancer-related morbidity and mortality in men. A promising target for immunotherapy is prostate-specific membrane antigen (PSMA), a transmembrane protein predominantly overexpressed in PCa, with expression levels correlating with tumor aggressiveness and …

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FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy

Haiwei Ni, Zachary J. Reitman, Wei Zou, Md. Naushad Akhtar et autres

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The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells

Qianqian Guo, Yi Zhou, Haiwei Ni, Miaomiao Niu et autres

BACKGROUND: The roles of the transcriptional factor SIX2 have been identified in several tumors. However, its roles in gastric cancer (GC) progression have not yet been revealed. Our objective is to explore the impact and underlying mechanisms of SIX2 on the stemness …

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Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis

Haiwei Ni, Guojing Ruan, Cheng Sun, Xuan Yang et autres

Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer cell stemness stays unclear. Here, we found …

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MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Haiwei Ni, Hai Qin, Cheng Sun, Yichen Liu et autres

BACKGROUND: Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced gastric carcinogenesis; here, we aim to explore the effects and mechanisms of miR-375 on gastric cancer (GC) cell …

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Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression

Yingying Xing, Guojing Ruan, Haiwei Ni, Hai Hong Qin et autres

MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that affects the progression of multiple diseases, especially cancer. MiRNA can participate in the biological processes of tumor, including proliferation, invasion and escape, and exhibit tumor enhancement or inhibition. …

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HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1

Hai Liu, Hai Qin, Yi Zhou, Yuan Yin et autres

Abstract Ours and other previous studies have shown that CYP4Z1 is specifically and highly expressed in breast cancer, and acts as a promoter for the stemness of breast cancer cells. Here, we explored whether targeting CYP4Z1 could attenuate the stemness of breast …

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Gene expression profiles in premenopausal women with HR+ HER2- early breast cancer

Haiwei Ni, A Kurt, Joerg Kumbrink, A. Seiler et autres

Early breast cancer (EBC) is not a single disease but consists of several clinically relevant molecular subtypes. Gene profiles correlated with important tumor pathways such as metastasis, immune response and proliferation also correlate with clinical outcome and therapy response. Premenopausal patients often …

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MiR-375 inhibits the stemness of breast cancer cells by blocking the JAK2/STAT3 signaling

Qiong Zhao, Yichen Liu, Ting Wang, Yue Yang et autres

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RNA-binding proteins in tumor progression

Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan et autres

RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA, including regulating RNA splicing, polyadenylation, mRNA stability, mRNA localization, and translation. Alteration …

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Correction to: Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells

Lufeng Zheng, Qianqian Guo, Chenxi Xiang, Shijia Liu et autres

The original article [1] contained an error in Fig. 7c whereby the same flow image was accidentally misused for the second and fourth group.

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