Guojing Ruan

Probiotics for the Treatment of Gastric Diseases

Yingying Xing, Xinyue Gu, Guojing Ruan, Simiao Chen

Common gastric diseases include chronic gastritis, gastric ulcers and gastric cancer. The etiology of gastric diseases is complicated, including genetics, diet, excessive smoking and drinking, environmental factors, and bacterial infections. As live microorganisms, probiotics can confer health benefits to the host. At …

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Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis

Haiwei Ni, Guojing Ruan, Cheng Sun, Xuan Yang et autres

Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer cell stemness stays unclear. Here, we found …

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CD4+ CD8αα+ T cells in the gastric epithelium mediate chronic inflammation induced by Helicobacter felis

Guojing Ruan, An Huang, Chupeng Hu, Ningyin Xu et autres

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MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Haiwei Ni, Hai Qin, Cheng Sun, Yichen Liu et autres

BACKGROUND: Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced gastric carcinogenesis; here, we aim to explore the effects and mechanisms of miR-375 on gastric cancer (GC) cell …

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Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression

Yingying Xing, Guojing Ruan, Haiwei Ni, Hai Hong Qin et autres

MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that affects the progression of multiple diseases, especially cancer. MiRNA can participate in the biological processes of tumor, including proliferation, invasion and escape, and exhibit tumor enhancement or inhibition. …

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Bacteroides fragilis controls intestinal inflammation through promoting Treg differentiation via TGF-β/Smad3 signaling pathway

Menghui Fan, Zhenxing Zhang, Guojing Ruan, Wei Fang et autres

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Helicobacter pylori induces gastric cancer via down‐regulating miR‐375 to inhibit dendritic cell maturation

Zhenxing Zhang, Simiao Chen, Menghui Fan, Guojing Ruan et autres

BACKGROUND: Recent studies and clinical samples have demonstrated that Helicobacter pylori could induce the downregulation of miR-375 in the stomach and promote gastric carcinogenesis. However, whether the immune cells are affected by Helicobacter pylori due to the downregulation of miR-375 is unclear. …

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CD4+ CD8αα+ T Cells in the Gastric epithelium Mediate Chronic Inflammation Induced by Helicobacter Felis

Guojing Ruan, An Huang, Chupeng Hu, Ningyin Xu et autres

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Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

Chupeng Hu, Wei Liu, Ningyin Xu, An Huang et autres

Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections. Our previous study reported that gastric subserous layer (GSL) vaccination induced a “pool” of protective tissue-resident memory CD4+T (CD4+TRM) cells in the …

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Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

Chupeng Hu, Wei Liu, Ningyin Xu, An Huang et autres

Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections. Our previous study reported that gastric subserous layer (GSL) vaccination induced a “pool” of protective tissue-resident memory CD4+T (CD4+TRM) cells in the …

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Vaccine‐induced gastric CD4+ tissue‐resident memory T cells proliferate in situ to amplify immune response against Helicobacter pylori insult

Ningyin Xu, Guojing Ruan, Wei Liu, Chupeng Hu et autres

Abstract Background Tissue‐resident memory T cells accelerate the clearance of pathogens during recall response. However, whether CD4+ TRM cells themselves can provide gastric immunity is unclear. Materials and methods We established a parabiosis model between the enhanced green fluorescent protein and wild‐type …

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