Sophia Göricke

Melanoma of the Choroid and Ciliary Body in Children: Remission of Metastatic Melanoma of the Choroid After Treatment With Chemotherapy and Immune Checkpoint Inhibition

Pia Tüller, Tobias Kiefer, Leyla Jabbarli, Kyriaki Papaioannou et autres

BACKGROUND: Uveal melanoma is the most common malignant primary intraocular tumor in adults, associated with high mortality. Pediatric uveal melanoma generally has a more favorable course. However, when metastasis occurs, therapeutic options are limited. DESIGN: Clinical presentation, treatment, and outcome of children …

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Susceptibility-based investigation of deep gray matter in common types of degenerative cerebellar ataxias

Andreas Deistung, Simon Graf, Dominik Jäschke, Sophia Göricke et autres

Motivation: The understanding about iron metabolism and its potential contribution to pathology in cerebellar ataxias is limited. Goal(s): Our aim was to measure tissue magnetic susceptibility, indicating iron concentration, in deep gray matter across common types of degenerative cerebellar ataxias. Approach: Volume-of-interest …

Melanoma of the choroid and ciliary body in children: Remission of metastatic melanoma of the choroid after treatment with chemotherapy and immune checkpoint inhibition

Pia Tüller, Tobias Kiefer, Leyla Jabbarli, Kyriaki Papaioannou et autres

Background: Uveal melanoma is the most common malignant primary intraocular tumor in adults, associated with high mortality. Pediatric uveal melanoma generally has a more favorable course. However, when metastasis occurs, therapeutic options are limited. Design: Clinical presentation, treatment, and outcome of children …

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The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation

Dana M. Huvermann, Adam M. Berlijn, Andreas Thieme, Friedrich Erdlenbruch et autres

To survive and thrive in our ever-changing environment, we need to be able to predict the consequences of our actions. We update these predictions by learning through trial and error, and associated prediction errors (PEs). Recent rodent data suggest that the cerebellum …

Optic nerve thickening on high-resolution MRI predicts early-stage postlaminar optic nerve invasion of retinoblastoma.

Christiaan M. de Bloeme, Sabien van Elst, Sophia Göricke, Pim de Graaf

Two radiologists with different levels of experience measured the anterior optic nerve to predict postlaminar optic nerve invasion (PLONI) in retinoblastoma. In addition, quantitative measurements were performed using a deep-learning method 3D U-net. The results showed that measurements performed by the radiologists …

Follow-up of Cystic Pineal Glands in Retinoblastoma Patients Does Not Increase Detection of Pineal Trilateral Retinoblastoma

Christiaan M. de Bloeme, Robin W. Jansen, Joeka de Haan, Debbie Pieperjohanns et autres

PURPOSE: To evaluate the effectiveness of baseline screening and follow-up with magnetic resonance imaging (MRI) for detecting trilateral retinoblastoma (TRb) and assessing the risk of TRb development. DESIGN: Prospective multicenter cohort study. METHODS: A total of 607 retinoblastoma patients from 2012 through …

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The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation

Dana M. Huvermann, Adam M. Berlijn, Andreas Thieme, Friedrich Erdlenbruch et autres

To survive and thrive in our ever-changing environment, we need to be able to predict the consequences of our actions. We update these predictions by learning through trial and error, and associated prediction errors (PEs). Recent rodent data suggest that the cerebellum …

de, ca (code pays fourni par la source)

Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study

Christian Hoffmann, Toke Printz Ringbæk, Anja Eckstein, W. Deya et autres

Irradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rates while preventing cataract formation. All consecutive patients …

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MRI-based long-term follow-up of indolent orbital lymphomas after curative radiotherapy: imaging remission criteria and volumetric regression kinetics

Christian Hoffmann, Christopher Mohr, Patricia Johansson, Anja Eckstein et autres

We systematically analyzed the kinetics of tumor regression, the impact of residual lesions on disease control and the applicability of the Lugano classification in follow-up MRI of orbital non-Hodgkin lymphomas that were irradiated with photons. We retrospectively analyzed a total of 154 …

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Long‐term follow‐up and health‐related quality of life among cancer survivors with stage IEA orbital‐type lymphoma after external photon‐beam radiotherapy: Results from a longitudinal study

Christian Hoffmann, Philipp Rating, Nikolaos E. Bechrakis, Anja Eckstein et autres

We assessed the long-term outcomes and treatment-related adverse effects of patients with Stage I, "orbital-type" lymphomas that were uniformly treated with photons. All consecutive patients diagnosed with low-grade, Ann Arbor Stage IEA orbital lymphoma treated between 1999 and 2020 at our department …

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Adjuvant Therapy for Children with Primary Enucleation of Retinoblastoma: A Report from a Prospective Multicenter Observational Study

Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck et autres

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Motor training‐related brain reorganization in patients with cerebellar degeneration

Rossitza Draganova, Frank Konietschke, Katharina M. Steiner, Naveen Elangovan et autres

Cerebellar degeneration progressively impairs motor function. Recent research showed that cerebellar patients can improve motor performance with practice, but the optimal feedback type (visual, proprioceptive, verbal) for such learning and the underlying neuroplastic changes are unknown. Here, patients with cerebellar degeneration (N …

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