The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation
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Le résumé fourni par la source
To survive and thrive in our ever-changing environment, we need to be able to predict the consequences of our actions. We update these predictions by learning through trial and error, and associated prediction errors (PEs). Recent rodent data suggest that the cerebellum – a region typically associated with processing sensory PEs in supervised error-based learning – also processes PEs in reinforcement learning (RL-PEs; i.e., learning from action outcomes). A proxy of action outcome processing in regions traditionally associated with RL-PE coding, such as striatum and anterior cingulate cortex, can be measured in a component of the feedback-locked event-related potential (ERP), i.e., the feedback-related negativity (FRN). We tested the hypothesis that cerebellar output is necessary for this RL-PE coding in the FRN in a probabilistic feedback learning task. In that case, altered cerebellar output should result in changes in the FRN. Two complementary experiments were performed. First, patients with chronic cerebellar stroke were tested. Second, single-pulse cerebellar transcranial magnetic stimulation (TMS) was applied in healthy participants, thus implementing a virtual lesion approach. Different from controls and control (vertex) TMS, no significant RL-PE processing was observed in the FRN in patients with cerebellar stroke, and in participants receiving cerebellar TMS. Only minor deficits in behavioural flexibility were found, with learning success preserved, possibly due to compensation by other brain areas within the reinforcement learning network. Findings in both experiments show that frontal RL-PE processing depends on cerebellar output. Our results provide evidence for involvement of the cerebellum in processing of RL-PEs in humans, complementing and extending previous findings in rodents.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation
- Date Crossref
- 22/05/2024
- Éditeur
- Center for Open Science
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Essen University Hospital Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS) pays non établi dans la noticeOrganisme public
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Heinrich Heine University Düsseldorf pays non établi dans la noticeUniversité ou école supérieure
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University of Duisburg-Essen pays non établi dans la noticeUniversité ou école supérieure
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Forschungszentrum Jülich pays non établi dans la noticeStructure de recherche
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Düsseldorf University Hospital pays non établi dans la noticeÉtablissement de santé
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Centre for Movement Disorders pays non établi dans la noticeÉtablissement de santé
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University Hospital in Halle pays non établi dans la noticeÉtablissement de santé
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Ruhrlandklinik pays non établi dans la noticeÉtablissement de santé
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MSH Medical School Hamburg – University of Applied Sciences and Medical University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Mathematics and Natural Sciences pays non établi dans la noticeUniversité ou école supérieure
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Institute of Neuroscience and Medicine (INM-1) pays non établi dans la noticeStructure de recherche
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Department of Neurology pays non établi dans la noticeInstitution
Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS) — Essen University Hospital, Heinrich Heine University Düsseldorf et University of Duisburg-Essen, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.