Daniele Fanoni

The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Alessandro Pileri, Alba Guglielmo, Vieri Grandi, Silvia Alberti Violetti et autres

BACKGROUND: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. METHODS: This …

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Newly-Discovered Neural Features Expand the Pathobiological Knowledge of Blastic Plasmacytoid Dendritic Cell Neoplasm

Maria Rosaria Sapienza, Giuseppe Benvenuto, Manuela Ferracin, Saveria Mazzara et autres

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy originating from plasmacytoid dendritic cells (pDCs). The microRNA expression profile of BPDCN was compared to that of normal pDCs and the impact of miRNA dysregulation on the BPDCN …

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Clinical and serological predictors of relapse in pemphigus: a study of 143 patients

Giovanni Genovese, Carlo Alberto Maronese, Giovanni Casazza, Laura Corti et autres

BACKGROUND: Pemphigus is an autoimmune bullous disease mediated by autoantibodies targeting epithelial cell-cell adhesion molecules. Predictors of relapse have not yet been clearly identified. AIMS: To identify factors at diagnosis and during follow-up that could be predictors of relapse. METHODS: Clinical and …

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Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma

Armando N. Bastidas Torres, Davy Cats, Jacoba J. Out‐Luiting, Daniele Fanoni et autres

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of genetic alterations driving pcAECyTCL has been performed, nor …

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Immunohistochemical expression and prognostic role of CD10, CD271 and Nestin in primary and recurrent cutaneous melanoma

Elena Guanziroli, Luigia Venegoni, Daniele Fanoni, Stefano Cavicchini et autres

BACKGROUND: CD10, CD271 and Nestin, which are proteins associated with tumor-initiating properties and/or progression potential, have not been specifically studied on malignant melanoma (MM) with cutaneous recurrences.METHODS: We evaluated the expression of CD10, CD271 and Nestin in 27 tumor samples from 16 …

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Immunohistochemical expression and prognostic role of CD10, CD271 and Nestin in primary and recurrent cutaneous melanoma.

Elena Guanziroli, Luigia Venegoni, Daniele Fanoni, Stefano Cavicchini et autres

BACKGROUND: CD10, CD271 and Nestin, which are proteins associated with tumor-initiating properties and/or progression potential, have not been specifically studied on malignant melanoma (MM) with cutaneous recurrences. METHODS: We evaluated the expression of CD10, CD271 and Nestin in 27 tumor samples from …

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Detection of IgE autoantibodies in mucous membrane pemphigoid and their association with disease severity

Laura Corti, Daniele Fanoni, Luigia Venegoni, Simona Muratori et autres

BACKGROUND: Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by scarring lesions at mucosal sites. Although the pathogenic role of specific IgG and/or IgA has been already demonstrated and the detection of these immunoglobulins is a criterion in the diagnosis of …

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Merkel cell carcinoma: a single-institution retrospective case series analyzing CD271 expression with a focus on its prognostic role

Elena Guanziroli, Luigia Venegoni, Daniele Fanoni, Emilio Berti

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Clinical and immunopathologic features of idiopathic cutaneous immunoglobulin M/G vasculitis versus idiopathic skin-limited immunoglobulin A vasculitis

Angelo Valerio Marzano, Giovanni Genovese, Simona Tavecchio, Francesca Germiniasi et autres

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Whole‐genome analysis uncovers recurrent IKZF1 inactivation and aberrant cell adhesion in blastic plasmacytoid dendritic cell neoplasm

Armando N. Bastidas Torres, Davy Cats, Hailiang Mei, Daniele Fanoni et autres

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematological malignancy with a poorly understood pathobiology and no effective therapeutic options. Despite a few recurrent genetic defects (eg, single nucleotide changes, indels, large chromosomal aberrations) have been identified in …

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Oesophagitis Dissecans Superficialis as the Presenting Sign of Isolated Oesophageal Mucous Membrane Pemphigoid

Giovanni Genovese, Elisabetta Filippi, Alberto Prada, Daniele Fanoni et autres

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Evidence for a role of autoinflammation in early-phase psoriasis

Daniele Fanoni, Luigia Venegoni, Barbara Vergani, Simona Tavecchio et autres

Psoriasis is a common, inflammatory immune-mediated skin disease mainly presenting with plaques whose pathogenesis is based on the central role of the interleukin (IL)-23/IL-17 axis. However, the mechanisms acting in papular lesions of early-phase psoriasis are not fully understood. The aim of …

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