Immunohistochemical expression and prognostic role of CD10, CD271 and Nestin in primary and recurrent cutaneous melanoma.
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: CD10, CD271 and Nestin, which are proteins associated with tumor-initiating properties and/or progression potential, have not been specifically studied on malignant melanoma (MM) with cutaneous recurrences. METHODS: We evaluated the expression of CD10, CD271 and Nestin in 27 tumor samples from 16 patients. These tumor samples corresponded to 6 primary melanomas which developed 11 ITM and 10 primary melanomas without recurrences at 10-year follow-up from specimens obtained from surgical excisions of patients referred to the Unit of Dermatology, Department of Medical-Surgical and Transplant Physiopathology, University of Milan, between 2006 and 2016. RESULTS: We demonstrated a higher expression of CD271 and Nestin in primary tumors which recurred than control population, Nestin was expressed with significantly higher percentages in primary tumors than recurrences, and CD10 expression was statistically significant correlated with disease-free survival: cases with a lower score recurred lately than cases with higher scores. CONCLUSIONS: Our preliminary results suggested that CD271 and Nestin can be considered early biomarkers for the development of ITM, Nesting can be useful in differentiating primary MM from cutaneous recurrences and CD10 is associated with a rapid disease progression and may be considered a potential prognostic marker.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immunohistochemical expression and prognostic role of CD10, CD271 and Nestin in primary and recurrent cutaneous melanoma
- Date Crossref
- 01/04/2021
- Éditeur
- Edizioni Minerva Medica
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico IRCCS Fondazione Ca' Granda pays non établi dans la noticeÉtablissement de santé
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Ospedale Maggiore Unit of Dermatology pays non établi dans la noticeÉtablissement de santé
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University of Milan Department of Medical-Surgical and Transplant Physiopathology pays non établi dans la noticeUniversité ou école supérieure
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Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti pays non établi dans la noticeInstitution
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Dipartimento di Scienze Biomediche pays non établi dans la noticeInstitution
IRCCS Fondazione Ca' Granda — Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Unit of Dermatology — Ospedale Maggiore et Department of Medical-Surgical and Transplant Physiopathology — University of Milan, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.