Ying Hu

Advancing regenerative medicine: the Aceman system’s pioneering automation and machine learning in mesenchymal stem cell biofabrication

Yi Ding, Yuqiang Chen, Kai Su, Jintu Zheng et autres

Mesenchymal stem cells (MSCs) are pivotal in advancing regenerative medicine; however, the large-scale production of MSCs for clinical applications faces significant challenges related to efficiency, cost, and quality assurance. We introduce the Automated Cell Manufacturing System (Aceman), a revolutionary solution that leverages …

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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo

Zheng Wang, Yu Liu, Yunxia Xu, Linlin Lu et autres

Currently approved human epidermal growth factor receptor 2 (HER2)-targeted antibody therapies are largely derived from trastuzumab, including trastuzumab-chemotherapy combinations, fixed-dose trastuzumab-pertuzumab combinations, and trastuzumab antibody-drug conjugates. To expand the options, bispecific antibodies, which may better utilize the benefits of combination therapy, are …

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[Mechanism of IL-17 Signaling Pathway in Spleen Inflammatory Response Induced by Altitude Hypoxia in Mice].

Sheng Yong, Yaqiu Guo, Xiaochen Chen, Yuzhen Xu et autres

Objective: To explore the mechanism of spleen tissue inflammatory response induced by altitude hypoxia in mice. Methods: C57BL/6 mice were randomly assigned to a plain, i.e., low-altitude, normoxia group and an altitude hypoxia group, with 5 mice in each group. In the …

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Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response

J Wang, Ying Hu, Yuzhen Xu, Qifu Long et autres

High-altitude hypoxia exposure can lead to phospholipase D-mediated lipid metabolism disorder in spleen tissues and induce ferroptosis. Nonetheless, the key genes underlying hypoxia-induced splenic phospholipase D and the ferroptosis pathway remain unclear. This study aimed to establish a hypoxia animal model. Combined …

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Alantolactone induces platelet apoptosis by activating the Akt pathway

Yueyue Sun, Mengnan Yang, Shujun Li, Ying Hu et autres

Alantolactone (ALT), a sesquiterpene lactone compound isolated from Inula helenium L., has recently attracted much attention for its anti-tumor properties. ALT reportedly functions by regulating the Akt pathway, which has been shown to be involved in programmed platelet death (apoptosis) and platelet …

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The role of acetaldehyde dehydrogenase 2 in the pathogenesis of liver diseases

Yincui Wu, Yan Yao, Liang-song Tao, Shuxian Wang et autres

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Recombinant EGFL7 Mitigated Pressure Overload-Induced Cardiac Remodeling by Blocking PI3Kγ/AKT/NFκB Signaling in Macrophages

Lei Li, Ying Zhao, Ying Hu, Xiaohui Wang et autres

Inflammation and endothelial dysfunction play an essential role in heart failure (HF). Epidermal growth factor-like protein 7 (EGFL7) is upregulated during pathological hypoxia and exerts a protective role. However, it is unclear whether there is a link between abnormal EGFL7 expression and …

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Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone Metabolism

Shan Qi, Meng Li Shao, Ze Sun, Si Min Chen et autres

Diabetic osteoporosis (DOP) belongs to secondary osteoporosis caused by diabetes; it has the characteristics of high morbidity and high disability. In the present study, we constructed a type 1 diabetic rat model and administered chondroitin sulfate (200 mg/kg) for 10 weeks to …

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Lycopene ameliorates diabetic osteoporosis via anti-inflammatory, anti-oxidation, and increasing Osteoprotegerin/RANKL expression ratio

Shan Qi, Meng Li Shao, Ze Sun, Si Min Chen et autres

Diabetic osteoporosis (DOP) is one of the complications of diabetes, with high morbidity, and high disability rate. Here, we established a diabetic rat model and administered lycopene to observe its effect on DOP. Our results showed that ten weeks lycopene treatment lowered …

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Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model

Jing Wu, Yuchuan Dai, Xing-Yu Lan, Hongfeng Zhang et autres

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Recombinant EGFL7 Mitigated Pressure Overload Induced Cardiac Remodelling Through Blocking PI3Kγ/AKT/NFκB Signalling in Macrophage

Lei Li, Ying Zhao, Ying Hu, Xiaohui Wang et autres

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Injectable Chitosan-Based Thermosensitive Hydrogel/Nanoparticle-Loaded System for Local Delivery of Vancomycin in the Treatment of Osteomyelitis

Jin Tao, Yang Zhang, Ao Shen, Yunxu Yang et autres

Purpose: Osteomyelitis, particularly chronic osteomyelitis, remains a major challenge for orthopedic surgeons. The traditional treatment for osteomyelitis, which involves antibiotics and debridement, does not provide a complete solution for infection and bone repair. Antibiotics such as vancomycin (VCM) are commonly used to …

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