Sarah‐Jane Guild

Long-term brain pressure monitoring via a discrete microimplant; a first-in-human safety and initial efficacy trial in adults and children with hydrocephalus

Simon C. Malpas, Bryon E. Wright, Sarah‐Jane Guild, Peter Heppner et autres

Emerging neurotechnologies such as brain-computer interfaces and implantable sensors offer considerable promise in the treatment of a broad range of neurological conditions. The key challenges are reducing the implant size, powering it, and confirming long-term accuracy and safety. Here we report the …

nz (code pays fourni par la source)

59579 New Innovation in the Management of Pediatric Hydrocephalus via a Novel Long Term ICP Pressure Sensor

Simon C. Malpas, Peter Heppner, Sarah‐Jane Guild, Sang Ho Kim

INTRODUCTION: It is well recognized that the management of hydrocephalus is difficult with evidence suggesting that 2/3 of the presentations to hospital with suspected shunt failure are deemed false alarms. The unmet clinical need is to provide data on ICP to guide …

Exercise modulates brain pulsatility: Insights from q-aMRI and MRI-based flow methods

Emma Clarkson, Itamar Terem, Alireza Sharifzadeh-Kermani, Josh McGeown et autres

Motivation: The interaction between cranial fluid flow and brain displacement patterns following exercise has not been studied in an MRI context. Quantification of this relationship is now possible with the novel quantitative amplified MRI (q-aMRI) algorithm. Goal(s): Characterization of intracranial fluid dynamics …

3D amplified MRI (aMRI) and Dynamic Mode Decomposition (DMD) analysis of ICP-driven cranio-spinal motion

Haribalan Kumar, Eryn Kwon, J. T. M. Wright, Itamar Terem et autres

Motivation: Alterations in intracranial pressure (ICP) affect brain dynamics, with potential implications in idiopathic intracranial hypertension (IIH). Goal(s): To develop a dynamical analysis method that can help visualize differences in intracranial and intraspinal pulsatility following lumbar puncture. Approach: Dominant modal frequency and …

Atlas-Free Semi-Automatic Segmentation of Sheep Cerebrospinal Fluid Space from MRI

Jiantao Shen, Maryam Tayebi, Alireza Sharifzadeh-Kermani, Eryn Kwon et autres

Automatic segmentation enables the rapid, reliable, and reproducible delineation of anatomical structures within the human brain from magnetic resonance imaging (MRI) scans. While large animal species, such as sheep, are extensively used in experimental brain research, limited research exists on automating the …

nz, ru, us (code pays fourni par la source)

Exercise modulates brain pulsatility: insights from q-aMRI and MRI-based flow methods

J. Wright, Emma Clarkson, Itamar Terem, Alireza Sharifzadeh-Kermani et autres

This study investigates intracranial dynamics following the Monro–Kellie doctrine, depicting how brain pulsatility, cerebrospinal fluid (CSF) flow and cerebral blood flow (CBF) interact under resting and exercise conditions. Using quantitative amplified magnetic resonance imaging (q-aMRI) alongside traditional MRI flow metrics, we measured …

nz, lk, es, us (code pays fourni par la source)

False alarms and the burden of shunt failure in pediatric patients with hydrocephalus: a longitudinal study

Sang Ho Kim, Peter Heppner, Yu Jin Kim, Sarah‐Jane Guild et autres

OBJECTIVE: This study aimed to investigate the burden of CSF shunt failure and false alarms on pediatric patients with hydrocephalus, their caregivers, and the healthcare system. METHODS: This retrospective longitudinal study examined pediatric patients who underwent CSF shunt procedures at Auckland City …

nz (code pays fourni par la source)

Toward a detailed subject-specific cerebrovascular model using Arterial Spin Labeling (ASL) Magnetic Resonance Imaging (MRI)

Alireza Sharifzadeh-Kermani, Finbar Argus, Jiantao Shen, Sarah‐Jane Guild et autres

Computed flows via haemodynamic models highly depend on peripheral resistances that affect the blood perfusion. To this end, finding a way to estimate these resistances is crucial for having a subject-specific model. Perfusion (CBF) maps produced by Arterial Spin Labeling (ASL)-MRI provide …

Alterations of brain motion in idiopathic intracranial hypertension (IIH) based on amplified MRI (aMRI)

Haribalan Kumar, Matthew McDonald, Alireza Sharifzadeh, J. T. M. Wright et autres

Heartbeat-driven brain motion has historically remained limited to the domain of research. Such motion may provide a window to characterise parenchymal and CSF pressures where direct, invasive measurements are disruptive and difficult to justify. Amplified MRI (aMRI) is a recently developed method …

Histological Characterisation of a Sheep Model of Mild Traumatic Brain Injury: A Pilot Study

Sheryl Tan, Danica Hamlin, Eryn Kwon, Miriam Scadeng et autres

Large animal models of mild traumatic brain injury (mTBI) are needed to elucidate the pathophysiology of mechanical insult to a gyrencephalic brain. Sheep (ovis aries) are an attractive model for mTBI because of their neuroanatomical similarity to humans; however, few histological studies …

nz, ru (code pays fourni par la source)

Correlating Raised Intracranial Pressure with Increased Brain Motion in a Ovine Model

A. Little, Eryn Kwon, Soroush Safaei, Gonzalo D. Maso Talou et autres

Heartbeat-driven brain motion has historically remained limited to the domain of research. Such motion may provide a window into conditions that alter the brain pressure where direct, invasive measurements are difficult to justify. Amplified MRI (aMRI) is a recently developed method which …

Atlas-Free Automatic Segmentation of Sheep Brain MRI

Jiantao Shen, Alireza Sharifzadeh-Kermani, Maryam Tayebi, Eryn Kwon et autres

Automated 3D brain segmentation methods have been shown to produce fast, reliable, and reproducible segmentations from magnetic resonance imaging (MRI) sequences for the anatomical structures of the human brain. Despite the extensive experimental research utility of large animal species such as the …

nz, ru (code pays fourni par la source)