James R. Roede

Crosstalk between cysteine and lysine modifications: Integrating redox and metabolic regulation

Emily C. Mitchem, James R. Roede, Kristofer S. Fritz

Protein post-translational modifications (PTMs) on amino acid residues enable dynamic cellular responses to changes in metabolic and redox state. Cysteine and lysine are among the most extensively modified amino acid residues, with both undergoing a diversity of acylation and oxidative modifications. Indeed, …

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Impact of overexpression of wild-type CFTR and elexacaftor-tezacaftor-ivacaftor on oxylipin production by the CFBE41o- bronchial epithelial cell line

Dustin G. Brown, Jonathan Manke, Michael Armstrong, Sangya Yadav et autres

A hallmark of cystic fibrosis (CF) is dysregulated lipid metabolism marked by an imbalance of pro-inflammatory to pro-resolving metabolites. Despite the breadth of evidence associating mutation of the cystic fibrosis conductance regulator (CFTR) with dysregulation of the production of oxylipins, oxidized lipid …

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Deacetylation of SOD3 by Sirtuins Restores Furin Cleavage

Emily C. Mitchem, Peter J. F. Harris, Cole R. Michel, Courtney D. McGinnis et autres

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Deacetylation of SOD3 by sirtuins restores furin cleavage

Emily C. Mitchem, Peter S. Harris, Cole R. Michel, Courtney D. McGinnis et autres

Accumulation of superoxide radicals leads to disrupted redox signaling and oxidative damage. The primary extracellular scavenger of superoxide is extracellular superoxide dismutase (SOD3), a crucial enzyme in maintaining antioxidant status and proper immune function. SOD3 distribution to the extracellular matrix is determined …

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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: Insights into chronic kidney disease of unknown etiology

Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers et autres

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Glyoxalase 2 Coordinates de Novo Serine Metabolism

Marissa N. Trujillo, Erin Q. Jennings, Dominique O Farrera, Naoya Kitamura et autres

Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in de novo Ser biosynthesis. Numerous metabolic pathways rely on Ser as a precursor, most notably one-carbon metabolism, glutathione biosynthesis, and de novo nucleotide biosynthesis. To facilitate proliferation, many cancer cells shunt glycolytic flux through …

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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology

Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers et autres

INTRODUCTION: Chronic kidney disease of unknown etiology (CKDu) is an epidemic which is increasingly prevalent among agricultural workers and nearby communities, particularly those involved in the harvest of sugarcane. While CKDu is likely multifactorial, occupational exposure to silica nanoparticles (SiNPs), a major …

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Acetylation of proximal cysteine-lysine pairs by alcohol metabolism

Courtney D. McGinnis, Peter S. Harris, Brenton I.M. Graham, John Marentette et autres

) each with a unique microenvironment. The motifs are composed of functionally relevant Cys-Ly altered within ALD, identifying potential therapeutic targets. Furthermore, these unique Cys-Lys redox signatures are translationally relevant as revealed by orthologous comparison with severe alcohol-associated hepatitis (SAH) explants, revealing …

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Impact of mitochondrially-targeted agents on compartmental redox status and mitochondrial function in euploid and Down syndrome fibroblasts.

John Marentette, James R. Roede, Robert Bessett

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A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice

Taylor Mills, Bailee Nicole Kain, Matt A. Burchill, Etienne P. Danis et autres

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Metabolic vulnerabilities in Down syndrome B-cell acute lymphoblastic leukemia can be targeted using Venetoclax

Dallas Jones, Elena Woods, Zhenhua Li, K Schaller et autres

Abstract Children with Down syndrome (DS) and B-cell acute lymphoblastic leukemia (B-ALL) are at increased risk for treatment-related mortality and relapse, highlighting the need for new therapies. Leukemia cell lines (CLs) have been fundamental to understanding therapeutic responses to pharmacological agents. We …

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Dysregulation of hepatic one‐carbon metabolism in classical homocystinuria: Implications of redox‐sensitive DHFR repression and tetrahydrofolate depletion for pathogenesis and treatment

Kenneth N. Maclean, Philip D. Neill, Ryan R. Chanin, K. Joseph Hurt et autres

Abstract Cystathionine beta‐synthase‐deficient homocystinuria (HCU) is a life‐threatening disorder of sulfur metabolism. HCU can be treated by using betaine to lower tissue and plasma levels of homocysteine (Hcy). Here, we show that mice with severely elevated Hcy and potentially deficient in the …

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