Scott A. Rodeo

Differential Arterial Supply of the ACL and PCL Revealed by 7T-qMRI, Histology, and Micro-CT

Maximilian M. Mueller, Sebastian Rilk, Craig E. Klinger, Jerry Wang et autres

Background: Qualitative anatomical studies have reported ligament-specific differences in vascular organization in the anterior and posterior cruciate ligaments (ACL and PCL). Purpose: (1) To quantitatively map the regional arterial vascular supply of the ACL and PCL across standardized anatomical regions using 7-Tesla …

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Proceedings of the 2026 Biologics Research Think Tank Convened by AANA, American Orthopaedic Society for Sports Medicine, and the Biologic Association

Pablo Palafox‐Castillo, Jorge Chahla, Brian J. Cole, Michelle E. Kew et autres

The Arthroscopy Association of North America, the American Orthopaedic Society for Sports Medicine, and the Biologic Association convened the 2026 Biologics Research Think Tank on May 16, 2026, in Phoenix, Arizona, in conjunction with the Arthroscopy Association of North America Annual Meeting. …

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A Precision Medicine Framework to Improve Patient Care Using Orthobiologics

Daniel de la Huerta Meza, Purva Singh, Miguel Otero, Jonathan S. Kirschner et autres

The lack of consistent responses to treatment is a considerable challenge in the medical field, in part driven by the one-size-fits-all approach traditionally applied to developing and testing therapies. This approach has resulted in treatments that work for some patients but fail …

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Osteochondral Autograft Transfer for Focal Osteochondral Defects of the Knee

John Strony, Jason Ina, John M. Apostolakos, Jacob G. Calcei et autres

➢ Osteochondral autograft transfer (OAT) restores hyaline cartilage and subchondral bone in a single stage, offering a durable joint-preserving option for focal full-thickness articular cartilage defects in young, active patients. ➢ Optimal candidates have unipolar femoral condyle, patellofemoral, or tibial plateau lesions …

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Coronal knee alignment is directly related to knee medial‐to‐lateral bone density ratio

Craig E. Klinger, Robert E. Bilodeau, Maximilian M. Mueller, Peter K. Sculco et autres

Abstract Purpose To assess associations between coronal knee alignment and regional epiphyseal bone mineral density (BMD) using computed tomography (CT)‐derived Hounsfield units (HU) and compare medial‐to‐lateral ratios (MLRs) across alignment groups, and as a secondary aim, to evaluate the association of sex …

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Orthobiologics in 2025 and Beyond.

Shane A. Shapiro, Nicolas Giusti, Andres Lopez, Scott A. Rodeo et autres

Orthobiologics are biologic substances intended to enhance healing and treat a range of musculoskeletal pathologies. Commonly well-studied orthobiologics such as platelet-rich plasma, bone marrow aspirate concentrate, and micro-fragmented adipose tissue have more than 2 decades of scientific research and clinical use, although …

Early Anterior Cruciate Ligament Reconstruction Mitigates the Development of Posttraumatic Osteoarthritis in a Murine Anterior Cruciate Ligament Rupture Model

Julia S. Retzky, Camila B. Carballo, Lauren Simonian, Thomas M. Li et autres

Background: Up to 60% of patients develop posttraumatic osteoarthritis (PTOA) 10 to 25 years after anterior cruciate ligament reconstruction (ACLR). While some studies suggest that early ACLR may mitigate PTOA, other studies, by contrast, have found no difference in the timing of …

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Higher arterial supply in the distal quadriceps tendon: Results from 7‐Tesla quantitative magnetic resonance imaging, histology and high‐resolution computed tomography

Maximilian M. Mueller, Craig E. Klinger, Sebastian Conner‐Rilk, Jerry Wang et autres

PURPOSE: This study aimed to quantitatively assess relative arterial contributions to the quadriceps tendon (QT) using 7-Tesla quantitative magnetic resonance imaging (7T-qMRI), histology and high-resolution computed tomography (micro-CT) in a fresh-frozen human cadaveric model. METHODS: Six human cadaveric knee pairs were obtained …

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Tendon-Bone Interface Healing Improvement by Moderate Treadmill Exercise After Anterior Cruciate Ligament Reconstruction in a Murine Model

Yuki Okazaki, Yasushi Takata, Alex N. Piacentini, Wataru Morita et autres

Background: Recent studies have used the anterior cruciate ligament reconstruction (ACLR) mouse model to study the tendon-bone healing process. Although mechanical load has an important effect on ACL graft healing, only a limited number of studies have investigated the effect of treadmill …

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Platelet-Poor Plasma for Muscle Injuries: A Review of Mechanisms and Clinical Perspectives

G. Fernandes, Scott A. Rodeo

Background: Muscle injuries are a frequent challenge in professional sports, with hamstring injuries being particularly prevalent. Despite advances in rehabilitation protocols, recurrence rates remain high, and recovery timelines vary depending on injury location and severity. Purpose: To examine the roles of platelet-rich …

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BIOLOGIC AUGMENTATION OF MENISCUS REPAIR

Scott A. Rodeo, Henning Madry

Meniscus healing is a slow and imperfect process due to limited vascularity, relatively low cellularity of meniscus tissue, the dense matrix that limits cell migration, and the intra-articular environment with inflammatory and catabolic cytokines in the injured joint. The earliest attempt at …

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Regenerative Medicine: Tremendous Potential but Not Quite Ready for Prime-Time

Scott A. Rodeo

This guest editorial gives an overview of the field of regenerative medicine and the special issue.

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