Differential Arterial Supply of the ACL and PCL Revealed by 7T-qMRI, Histology, and Micro-CT
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Le résumé fourni par la source
Background: Qualitative anatomical studies have reported ligament-specific differences in vascular organization in the anterior and posterior cruciate ligaments (ACL and PCL). Purpose: (1) To quantitatively map the regional arterial vascular supply of the ACL and PCL across standardized anatomical regions using 7-Tesla quantitative magnetic resonance imaging (7T-qMRI), histology, and high-resolution computed tomography (micro-CT) in a fresh-frozen human cadaveric model; and (2) to directly compare vascular distribution patterns between cruciate ligaments. Study Design: Descriptive laboratory study. Methods: Seven fresh-frozen human cadaveric knee specimens (mean ± SD age, 41.9 ± 15.5 years) underwent pre- and postcontrast 7T-qMRI to quantify ligamentous vascularity by measuring contrast enhancement. Ligament zones were categorized based on relative distance from distal insertion as follows: 1 (≥90%), 2 (>75% to 90%), 3 (>25% to 75%), 4 (>10% to 25%), and 5 (≤10%). Subsequent quantitative algorithm-based histologic analysis with hematoxylin and eosin staining followed, and an additional specimen underwent micro-CT (98 μm) for qualitative assessment. Results: 7T-qMRI found relative arterial contributions as follows: for the ACL, zone 1, 10.2%; zone 2, 25.9%; zone 3, 24.8%; zone 4, 10.3%; and zone 5, 17.6%. For the PCL, zone 1, 9.3%; zone 2, 13.2%; zone 3, 16.7%; zone 4, 21.8%; and zone 5, 39.5%. Analysis revealed significant differences in overall contribution within soft tissue zones between the ACL and PCL (8.3% vs 27.1%; P = .02). Zone-by-zone analysis identified significant interligament differences in zone 2 and zone 4 ( P = .046 for both). Both tibial entheses (ACL, 87.7%; PCL, 76.9%) demonstrated higher vascularity compared with the femoral (ACL, 12.3%; PCL, 23.1%) (ACL, P = .02; PCL, P = .87). A 3-zone 7T-qMRI and histologic sensitivity analysis confirmed the distribution pattern. Conclusion: This study demonstrates a distinct, region-specific arterial distribution in the ACL and PCL. The ACL exhibited predominantly proximal vascular supply, whereas the PCL showed greater distal and overall arterial contribution. These quantitative differences in vascular organization provide a biological basis that may help explain ligament-specific healing behavior. Clinical Relevance: This study establishes 7T-qMRI as a methodology for quantitative comparison of vascularity between the ACL and PCL to support future translational studies investigating the relationship between vascular supply, ligament-specific healing patterns, and injury-specific treatment strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Differential Arterial Supply of the ACL and PCL Revealed by 7T-qMRI, Histology, and Micro-CT
- Date Crossref
- 01/08/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Cornell University Department of Orthopedic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Presbyterian Hospital pays non établi dans la noticeÉtablissement de santé
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BG Klinikum Hamburg pays non établi dans la noticeÉtablissement de santé
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Medical University of Vienna Department of Orthopedics and Trauma-Surgery pays non établi dans la noticeUniversité ou école supérieure
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Universität Hamburg pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center Hamburg-Eppendorf pays non établi dans la noticeÉtablissement de santé
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Stanford University pays non établi dans la noticeUniversité ou école supérieure
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New York University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Hospital for Special Surgery and Regeneration Program pays non établi dans la noticeÉtablissement de santé
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Department of Trauma Surgery pays non établi dans la noticeInstitution
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Orthopedic Surgery Munich pays non établi dans la noticeInstitution
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Department of Pathology and Lab Medicine pays non établi dans la noticeStructure de recherche
Department of Orthopedic Surgery — Cornell University, Presbyterian Hospital et BG Klinikum Hamburg, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.