Yuan Z. Gao

Rapid Detection and Purification of Extracellular Vesicles for Hepatocellular Carcinoma Screening Using a Plasmonic Metasurface Integrated with the Kolmogorov–Arnold Network

Jiaheng Zhu, Tianhao Huang, Qiang Niu, Xinyue Huang et autres

Hepatocellular carcinoma (HCC) is a leading cause of global cancer-related mortality, with delayed diagnosis adversely affecting patient outcomes. Liquid biopsy techniques using small extracellular vesicles (EVs) offer potential for cancer detection, though current methods are often time-consuming and require complex equipment, limiting …

cn, jp, us (code pays fourni par la source)

Effects of telitacicept and belimumab on systemic lupus erythematosus: a systematic review and meta-analysis

Jiawen Qian, Xiaoqing Lv, Yuxin Hu, Yuxin Zhang et autres

Abstract B cell-targeted therapies play an important role in systemic lupus erythematosus (SLE). Belimumab targets B lymphocyte stimulator (BLyS), whereas telitacicept inhibits both BLyS and APRIL. Although both drugs have demonstrated clinical efficacy in SLE, comparative benefits and risks of telitacicept versus …

cn (code pays fourni par la source)

Effects of Telitacicept and Belimumab on Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

Jiawen Qian, Xiaoqing Lv, Yuxin Hu, Yuxin Zhang et autres

cn (code pays fourni par la source)

Deep Learning‐Powered Nanoplasmonic Biosensing Approach Enables Ultrasensitive Extracellular Vesicles Profiling for Cancer Screening

Jiaheng Zhu, Yingqi Xiao, Xinyue Huang, Qiang Niu et autres

Nanoplasmonic metasurface technology, known for its high sensitivity, has garnered significant attention in the field of cancer detection. However, its potential is currently hindered by the inefficient data processing and analysis of conventional biosensing approaches. Herein, a biosensing strategy based on the …

cn (code pays fourni par la source)

The global patent landscape of the drugs for treating Alzheimer’s disease from 2014–2023

Yan Xu, Yuan Z. Gao

BACKGROUND: Alzheimer's Disease (AD) is a complex neurodegenerative disorder lacking a definitive cure, spurring global efforts to develop effective therapeutic agents. Patent data can provide critical insights into research investments, innovation trends, and market dynamics. OBJECTIVE: This study offers a comprehensive ten-year …

cn, my (code pays fourni par la source)

Synergistic effects of combined hypnotic drugs on sleep in mice

Rui Bai, Fanghui Wu, Yifeng Yin, Yanli Liu et autres

Study objectives: To investigate the interaction and potential mechanisms of the combined administration of dexmedetomidine (DMED) and eszopiclone (ESZ) on sleep in mice. Methods: The effects of DMED, ESZ and the combination of the two drugs on the sleep status of mice …

cn (code pays fourni par la source)

Intelligent non-destructive biosensing of fresh tea leaves by portable spectroscopy and enhanced transformer

Kaibin Chen, Yuan Z. Gao, Zhipeng Zhang, Yueyue Zhu et autres

cn, sg (code pays fourni par la source)

MiR-556-3p mediated repression of klotho under oxidative stress promotes fibrosis of renal tubular epithelial cells

Zongying Li, Yuan Z. Gao, Hailing Sun

Chronic kidney disease (CKD) is a global health issue characterized by renal fibrosis, which leads to irreversible tissue damage. Oxidative stress plays a key role in driving the fibrotic processes associated with CKD. This study investigates the roles of oxidative stress, miR-556-3p, …

cn (code pays fourni par la source)

Scriptaid Improves Cashmere Goat Embryo Reprogramming by Affecting Donor Cell Pluripotency Molecule NANOG Expression

Xiaoshu Zhe, Hairui Ma, Wenqi Zhang, Rui Ding et autres

Currently, the efficiency of somatic cell nuclear transfer (SCNT) technology is relatively low, primarily owing to reprogramming abnormalities in donor cells or reconstructed embryos. Using histone deacetylase inhibitor (HDACi) to artificially alter the epigenetic modifications of donor cells and improve the reprogramming …

cn (code pays fourni par la source)

Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response

Houren Zhou, Xinyu Zhang, Hui Liu, Yuan Z. Gao et autres

Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and high safety, and has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature is …

cn, sg (code pays fourni par la source)

Abstract TP20: Intravenous thrombolysis versus early antiplatelet therapy in acute Ischemic Stroke with Small Artery Occlusion

Yuan Z. Gao, zong ce, Ke Zhang, Hongbing Liu et autres

Backgrounds: There remained a debate about the efficacy and safety of intravenous thrombolysis (IVT) on functional outcome compared to early antiplatelet therapy for ischemic stroke patients with small artery occlusive (SAO), and whether it could reduce the occurrence of early neurological deterioration …

cn (code pays fourni par la source)

CXCR3 inhibition ameliorates mitochondrial function to mitigate oxidative damage through NCOA4-mediated ferritinophagy and improves the gut microbiota in mice

Yuan Z. Gao, Yian Deng, Wenjie Li, Junjie Wang et autres

cn (code pays fourni par la source)