Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response
Rattachement africain : cn, sg. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and high safety, and has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature is very necessary, which inevitably results in severe stress responses and cell death, thereby triggering harmful inflammation. Additionally, achieving effective controlled release of drugs in the tumor microenvironment to reduce systemic side effects is still a major challenge. Herein, an intelligent nanoplatform is first reported, which featured sulfide iron (FeS) nanosheets as the core, loaded with perfluorohexane (PFH), and skillfully coated with polydopamine (PDA). It can serve as a generator of reactive oxygen species (ROS) in the tumor microenvironment to induce tumor cell ferroptosis, further intensifying PTT, and as a ROS eliminator in normal tissue to effectively control the undesired inflammatory response during PTT, achieving a differential treatment strategy between tumor and surrounding normal tissue. Meanwhile, the combination of ultrasound‐targeted microbubble destruction (UTMD) technology significantly enhanced the local penetration and release of the drug. Overall, systemic delivery of FeS/PFH@PDA combined UTMD can achieve precise and efficient synergistic therapy for tumors and demonstrate outstanding ultrasound and MR dual‐mode imaging performance.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response
- Date Crossref
- 21/02/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dalian Medical University Ultrasound Department pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Dalian Medical University pays non établi dans la noticeÉtablissement de santé
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China Medical University Shengjing Hospital pays non établi dans la noticeUniversité ou école supérieure
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Shandong Tumor Hospital pays non établi dans la noticeÉtablissement de santé
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Shandong First Medical University Shandong Cancer Hospital and Institute pays non établi dans la noticeUniversité ou école supérieure
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National University of Singapore Department of Chemical and Biomolecular Engineering pays non établi dans la noticeUniversité ou école supérieure
Ultrasound Department — Dalian Medical University, Second Affiliated Hospital of Dalian Medical University et Shengjing Hospital — China Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.