Pezhman Fard‐Esfahani

FcIgG-GE11-Melittin as a novel EGFR targeted peptibody with potent cytotoxic activity against cancer cells

Malihe Hallaji, Shima Fayaz, Mojgan Allahyari, Majid Golkar et autres

The overexpression of epidermal growth factor receptor (EGFR) in various cancer types makes it an attractive target for therapeutic intervention. In this study, we designed a novel peptibody, FcIgG-GE11-Melittin, by fusing Melittin, a cytotoxic peptide from bee venom, to an EGFR-targeting peptibody …

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Targeted cancer treatment using a novel EGFR-specific Fc-fusion peptide based on GE11 peptide

Malihe Hallaji, Mojgan Allahyari, Ladan Teimoori‐Toolabi, Setayesh Yasami et autres

Fc-fusion peptides, also known as peptibodies, are a promising new category of targeted therapeutics that offer alternatives to monoclonal antibodies (mAbs) for cancer treatment. This study focuses on an Fc-fusion peptide consisting of the Fc region of IgG1 and an epidermal growth …

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Association of histidine-rich glycoprotein C633T single nucleotide polymorphism and recurrent miscarriage in Iranian women

Mahbobeh Latifimehr, Ali Asghar Rastegari, Zahra Zamani, Pezhman Fard‐Esfahani et autres

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The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women

Mahbobeh Latifimehr, Leila Nazari, Ali Asghar Rastegari, Zahra Zamani et autres

Purpose. Recurrent miscarriage (RM) is a significant reproductive concern affecting numerous women globally. Genetic factors are believed to play a crucial role in RM, making the histidine-rich glycoprotein (HRG) gene, a topic of interest due to its potential involvement in angiogenesis. This …

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Microrna 138 Upregulation is Associated with Decreasing Levels of CCND1 Gene Expression and Promoting Cell Death in Human Prostate Cancer Cell Lines

Nasrin Haghighi-Najafabadi, Shima Fayaz, Mahboubeh Berizi, Ghazal Haddad et autres

Background: This research intended to discover the significance of miR-138 (microRNA 138) on the expression profile, proliferation, and the associated regulatory mechanisms in prostate cancer (PCa). Methods: Thirty-five specimens of prostate were studied to evaluate the expression level of miR138 by RT-qPCR …

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Molecular identification of Phlebotomus kandelakii apyrase and assessment of the immunogenicity of its recombinant protein in BALB/c mice

Shima Fayaz, Abbasali Raz, Fariborz Bahrami, Pezhman Fard‐Esfahani et autres

Sand fly salivary proteins have immunomodulatory and anti-inflammatory features; hence, they are proven to perform important roles in the early establishment of Leishmania parasite in the vertebrate host. Among them, salivary apyrase with anti-hemostatic properties has a crucial role during the blood …

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MicroRNA 138 upregulation is associated with decreasing levels of CCND1 gene expression and promoting cell death in human prostate cancer cell lines

Nasrin Haghighi-Najafabadi, Shima Fayaz, Ghazal Haddad, Mahboubeh Berizi et autres

This research intended to discover the significance of miR-138 on the espression profile, proliferation, and the associated regulatory mechanisms in prostate cancer (PCa). RT-qPCR was applied to compare the expression of miR-138 in the PCa cells with a non-cancer cell line, as …

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Targeted integration in CHO cells using CRIS-PITCh/Bxb1 recombinase–mediated cassette exchange hybrid system

Samaneh Ghanbari, Elham Bayat, Masoumeh Azizi, Pezhman Fard‐Esfahani et autres

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Quality by Design in Downstream Process Development of Romiplostim

Saeedeh Pouri, Fatemeh Torkashvand, Hooman Aghamirza Moghim Aliabadi, Pezhman Fard‐Esfahani et autres

Background: Background: Downstream processing of therapeutic recombinant proteins expressed as the inclusion bodies (IBs) in E. coli is quite challenging. This study aimed to use the quality by design approach for developing the multi-step downstream process of a structurally complex therapeutic Fc-Peptide …

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Development of a Quantitative Real-Time PCR Assay for Detection of Toxoplasma gondii in Brain Samples

Mahboubeh Berizi, Jalal Babaie, Pezhman Fard‐Esfahani, Marjan Enshaeieh et autres

Background: Toxoplasmosis is a worldwide-distributed infection that can cause serious diseases, mainly in congenitally infected and immunodeficient individuals. PCR assays play an indispensable role in the detection of Toxoplasma gondii in different biological samples. Methods: This study was conducted in the Parasitology …

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Co-delivery of PLGA nanoparticles loaded with rSAG1 antigen and TLR ligands: An efficient vaccine against chronic toxoplasmosis

Mojgan Allahyari, Majid Golkar, Pezhman Fard‐Esfahani, Isabelle Dimier‐Poisson et autres

Although vaccination is a promising approach for the control of toxoplasmosis, there is currently no commercially available human vaccine. Adjuvants such as delivery vehicles and immunomodulators are critical components of vaccine formulations. In this study, Poly (D, l-lactide-co-glycolide) (PLGA) nanoparticles were applied …

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High resolution melting assay in discrimination of the main etiologic agents of leishmaniasis in Iran

Shima Fayaz, Pezhman Fard‐Esfahani, Fariborz Bahrami, Parviz Parvizi et autres

Background and Objectives: The three old world Leishmania species i.e., L. major, L. tropica, and L. infantum are considered as potential etiological agents of the various clinical forms of leishmaniasis in Iran. Different species co-exist in some areas. Accurate differentiation between the …

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