Majid Golkar

Streamlined design and production of bioactive variants of recombinant human keratinocyte growth factor to improve acidic pH stability; promising therapeutic candidates for wound treatment

Mansoureh Shahbazi Dastjerdeh, Mohammadtaghi Borjian Boroujeni, Setayesh Yasami‐Khiabani, Majid Golkar et autres

Keratinocyte Growth Factor (KGF) plays a crucial role in promoting epithelial cell proliferation, making it a valuable candidate for wound healing therapies. However, its instability in acidic environments limits its effectiveness in early-stage wound care. This study addresses the instability of recombinant …

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Streamlined design and production of bioactive variants of recombinant human keratinocyte growth factor to improve acidic pH stability; promising therapeutic candidates for wound treatment

Mansoureh Shahbazi Dastjerdeh, Mohammadtaghi Borjian Boroujeni, Setayesh Yasami‐Khiabani, Majid Golkar et autres

Keratinocyte Growth Factor (KGF) plays a crucial role in promoting epithelial cell proliferation, making it a valuable candidate for wound healing therapies. However, its instability in acidic environments limits its effectiveness in early-stage wound care. This study addresses the instability of recombinant …

Streamlined design and production of bioactive variants of recombinant human keratinocyte growth factor to improve acidic pH stability; promising therapeutic candidates for wound treatment

Mansoureh Shahbazi Dastjerdeh, Mohammadtaghi Borjian Boroujeni, Setayesh Yasami‐Khiabani, Majid Golkar et autres

Keratinocyte Growth Factor (KGF) plays a crucial role in promoting epithelial cell proliferation, making it a valuable candidate for wound healing therapies. However, its instability in acidic environments limits its effectiveness in early-stage wound care. This study addresses the instability of recombinant …

The rabies glycoprotein C-terminal peptide attenuates LPS-induced synaptic dysfunction and cognitive impairment in male rats

Mohsen Ilkhanizadeh-Qomi, Karen Dalvand, Samira Choopani, Mohammad Sayyah et autres

The rabies virus exhibits a specific neurotropism for neurons within the central nervous system. It encodes five proteins, one of them is glycoprotein RVG, which integrates into the host cell's plasma membrane. Our previous research found that RVG expression in hippocampal cells …

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FcIgG-GE11-Melittin as a novel EGFR targeted peptibody with potent cytotoxic activity against cancer cells

Malihe Hallaji, Shima Fayaz, Mojgan Allahyari, Majid Golkar et autres

The overexpression of epidermal growth factor receptor (EGFR) in various cancer types makes it an attractive target for therapeutic intervention. In this study, we designed a novel peptibody, FcIgG-GE11-Melittin, by fusing Melittin, a cytotoxic peptide from bee venom, to an EGFR-targeting peptibody …

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Cannabidiol Enhances Stress-Induced Cellular Damage: Potential Contribution of Kv2.1 Inhibition

Fatemeh Sayehmiri, Mohsen Ilkhanizadeh-Qomi, Nima Naderi, Arnaud Monteil et autres

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Targeted cancer treatment using a novel EGFR-specific Fc-fusion peptide based on GE11 peptide

Malihe Hallaji, Mojgan Allahyari, Ladan Teimoori‐Toolabi, Setayesh Yasami et autres

Fc-fusion peptides, also known as peptibodies, are a promising new category of targeted therapeutics that offer alternatives to monoclonal antibodies (mAbs) for cancer treatment. This study focuses on an Fc-fusion peptide consisting of the Fc region of IgG1 and an epidermal growth …

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Contribution of epidermal growth factor (EGF) in the treatment of cutaneous leishmaniasis caused by Leishmania major in BALB/c mice

Mohammad Reza Saberi, Alireza Latifi, Majid Golkar, Pezhman Fard-Esfahani et autres

Cutaneous leishmaniasis (CL) is a tropical disease that can cause chronic lesions and leave life-long scars, leading to social stigmatization and psychological disorders. Using growth factors and immunomodulatory agents that could accelerate wound healing and reduce the scar is highly demanded. Epidermal …

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Efficient periplasmic expression of active lysyl endopeptidase and optimizing the purification methods

Zahra Pourani, Malihe Keramati, Samira Komijani, Majid Golkar et autres

0.45 and 6 h incubation increased enzyme activity to 23.5 %, 13.3 %, and 76.4 %, respectively. The enzyme activity of Lys-C in the presence of 4 mM glutathione and extraction buffers containing 2 mM 2-mercaptoethanol (2 ME) was 81.6 % higher …

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Identification of new potential candidates to inhibit EGF via machine learning algorithm

Mohammadreza Torabi, Setayesh Yasami‐Khiabani, Soroush Sardari, Majid Golkar et autres

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Latent toxoplasmosis impairs learning and memory yet strengthens short-term and long-term hippocampal synaptic plasticity at perforant pathway-dentate gyrus, and Schaffer collatterals-CA1 synapses

Samira Choopani, Bahereh Kiani, Shayan Aliakbari, Jalal Babaie et autres

Investigating long-term potentiation (LTP) in disease models provides essential mechanistic insight into synaptic dysfunction and relevant behavioral changes in many neuropsychiatric and neurological diseases. Toxoplasma (T) gondii is an intracellular parasite causing bizarre changes in host's mind including losing inherent fear of …

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Proposing New Potential Candidates to Inhibit EGFR via Machine Learning Algorithm

Mohammadreza Torabi, Setayesh Yasami‐Khiabani, Soroush Sardari, Majid Golkar et autres

Abstract One of the main issues in solid tumours is progressive mutation in epidermal growth factor receptors (EGFR) gene, which activates signalling pathways that create new blood vessels. In this study, it was attempted to find new a therapeutic candidate to inhibit …

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