Accès ouvert
2026
article
OpenAlex
Yang Zhang, Xinyue Lu, Alexander K. Kunisky, Shahul Alam et autres
Alzheimer's disease (AD) disrupts brain function through cell type-specific transcriptomic and epigenomic alterations, yet the contribution of three-dimensional (3D) genome organization to AD remains poorly understood. We applied GAGE-seq (genome architecture and gene expression by sequencing) to jointly profile gene expression and …
us
(code pays fourni par la source)
Accès ouvert
2026
software
OpenAlex
Yang Zhang, Xinyue Lu, Alexander K. Kunisky, Shahul Alam et autres
This repository contains the code used for the data processing and analysis for paper: Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer’s disease. The code is organized into the following directories: GAGE_seq_pipeline_Hi-C: Contains scripts for processing the raw GAGE-seq Hi-C, …
us
(code pays fourni par la source)
Accès ouvert
2026
software
OpenAlex
Yang Zhang, Xinyue Lu, Alexander K. Kunisky, Shahul Alam et autres
This repository contains the code used for the data processing and analysis for paper: Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer’s disease. The code is organized into the following directories: GAGE_seq_pipeline_Hi-C: Contains scripts for processing the raw GAGE-seq Hi-C, …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yang Yue, Man Ho Wong, Xiaojie Huang, Delia N. Chiu et autres
At synapses, miniature synaptic transmission forms the basic unit of evoked transmission, thought to use one canonical transmission site. Two general types of synaptic plasticity, associative plasticity to change synaptic weights and homeostatic plasticity to maintain an excitatory balance, are so far …
us, de
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Hansruedi Mathys, Zhuyu Peng, Carles A. Boix, Matheus B. Victor et autres
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the molecular and cellular mechanisms underlying cognitive impairment remain poorly understood. To address this, we generated a single-cell transcriptomic atlas of the aged human prefrontal cortex covering 2.3 million cells …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
R. Samuel Herron, Alexander K. Kunisky, Jessica R Madden, Vivian I. Anyaeche et autres
Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the discovery that the mTORC1 signaling pathway balances the expression of two Trim9/TRIM9 isoforms through APA regulation in human and mouse. We showed that CFIm components, CPSF6 and NUDT21, …
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(code pays fourni par la source)
Accès ouvert
2023
peer-review
OpenAlex
R. Samuel Herron, Alexander K. Kunisky, Jessica R Madden, Vivian I. Anyaeche et autres
Genetics and biochemical analyses reveal an evolutionarily conserved mechanism to regulate gene isoform expression by mTORC1 and implicate possible gene isoform imbalance in cancer and neurological disorders with mTORC1 pathway dysregulation.
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(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
R. Samuel Herron, Alexander K. Kunisky, Jessica R Madden, Vivian I. Anyaeche et autres
SUMMARY Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the identification of a twin UGUA motif, UGUAYUGUA, and its function in APA. Applying cTag-PAPERCLIP to Tsc1 conditional knockout mice, we discovered that the mTORC1 pathway balances expression …
us
(code pays fourni par la source)
2022
article
OpenAlex
R. Samuel Herron, Alexander K. Kunisky, Hun‐Way Hwang
Alternative polyadenylation (APA), an RNA processing mechanism that results in mRNA with distinct 3’ termini, is a rapidly expanding area of research that in recent studies has been linked to the mechanistic target of rapamycin (mTOR) signaling pathway, a key regulatory pathway …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Alexander K. Kunisky, Vivian I. Anyaeche, R. Samuel Herron, Christopher Y. Park et autres
DNA damage reshapes the cellular transcriptome by modulating RNA transcription and processing. In cancer cells, these changes can alter the expression of genes in the immune surveillance and cell death pathways. Here, we investigate how DNA damage impacts alternative polyadenylation (APA) using …
us
(code pays fourni par la source)