Tiffanie‐Marie Borg

INSPIRE: Inclusivity in plastic surgery – Insights, recommendations, & education. A national cross-sectional study exploring perceptions of mentorship among aspiring plastic surgeons

Garikai Kungwengwe, Umar Rehman, Simon A. Filson, Elena Whiteman et autres

Background: Plastic surgery is a highly competitive surgical speciality in the United Kingdom. Barriers to entry disproportionately affect ethnic minority candidates. Limited mentorship, unequal access to research opportunities, and systemic biases contribute to differential attainment and hinder career progression. Methods: A national …

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Free Tissue Transfer for the Management of Diabetic Lower Limb Ulcers: A Systematic Review and Meta‐Analysis

Quillan Young Sing, Tiffanie‐Marie Borg, Yousif F Yousif, Konstantinos Devetzis et autres

ABSTRACT Background Diabetic foot ulcers are a major complication of diabetes, with resulting soft tissue defects increasing the risk of limb amputation and mortality. Reconstruction of defects may be in the form of local, pedicled, or free tissue transfer. This systematic review …

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Home cryolipolysis – A burning issue

Tiffanie‐Marie Borg, Katrina Campbell, J. Zhao, Sanjay Varma et autres

Cryolipolysis is a non-surgical technique for fat reduction whereby adipose tissue is exposed to low temperatures to induce apoptosis. This leads to a slow reabsorption of the excess tissue. The aim of this report is to increase awareness of the burns-related risks …

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Supplementary Figures S1, S2, S3, S4, S5 from Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma

Ankit Bharat Patel, Lucía Fraile García, Viviana Mannella, Luke Gammon et autres

Supplemental Information includes 5 Supplementary figures and legends: Figure S1: Correlation of p63 expression and BRAF/NRAS mutational status in melanoma and characterization of MAPKi resistant melanoma cell lines. Figure S2: p63 upregulation in MAPKi resistant melanoma. Figure S3: ITCH and FBXW7 expression …

Supplementary Figures S1, S2, S3, S4, S5 from Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma

Ankit Bharat Patel, Lucía Fraile García, Viviana Mannella, Luke Gammon et autres

Supplemental Information includes 5 Supplementary figures and legends: Figure S1: Correlation of p63 expression and BRAF/NRAS mutational status in melanoma and characterization of MAPKi resistant melanoma cell lines. Figure S2: p63 upregulation in MAPKi resistant melanoma. Figure S3: ITCH and FBXW7 expression …

Data from Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma

Ankit A. Patel, Lucía Fraile García, Viviana Mannella, Luke Gammon et autres

Abstract Targeting the MAPK pathway by combined inhibition of BRAF and MEK has increased overall survival in advanced BRAF-mutant melanoma in both therapeutic and adjuvant clinical settings. However, a significant proportion of tumors develop acquired resistance, leading to treatment failure. We have …

Data from Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma

Ankit A. Patel, Lucía Fraile García, Viviana Mannella, Luke Gammon et autres

Abstract Targeting the MAPK pathway by combined inhibition of BRAF and MEK has increased overall survival in advanced BRAF-mutant melanoma in both therapeutic and adjuvant clinical settings. However, a significant proportion of tumors develop acquired resistance, leading to treatment failure. We have …

The Effect of COVID-19 on Surgical Management of Skin Cancers of the Head, Face and Neck in Elderly Patients

Tiffanie‐Marie Borg, Jessica Eisold, Yusuf Miyanjo, Elena I. Pappa

Abstract Background The Corona Virus (COVID-19) has had a profound impact on healthcare systems worldwide, with interruptions to medical practices including the delivery of cancer treatment. Skin cancer is one of the leading causes of malignancy worldwide, with later stages of disease …

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The Medial Sural Artery Perforator Flap versus Other Free Flaps in Head and Neck Reconstruction: A Systematic Review

Yasser Al Omran, Ellie Evans, Chloe Louanne Jordan, Tiffanie‐Marie Borg et autres

Abstract The medial sural artery perforator (MSAP) flap is a versatile fasciocutaneous flap, and yet is less commonly utilized than other free flaps in microvascular reconstructions of the head and neck. The aim is to conduct a high-quality Preferred Reporting Items for …

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Similar local recurrence and survival in patients with T1 radial growth phase melanoma on head and neck treated with 5 or 10 mm margins: A retrospective study

Andrea Maurichi, Francesco Barretta, Roberto Patuzzo, Rosalba Miceli et autres

BACKGROUND: Melanoma guidelines recommend surgical excision with 10 mm margins for T1 melanomas (invasive melanomas with Breslow thickness ≤1 mm), including those in radial growth phase, which are without metastatic potential; however, such margins may be problematic on head-and-neck. OBJECTIVE: We compared …

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Surgical Management of Submucous Cleft Palate by Radical Muscle Dissection Veloplasty: Speech Outcomes in Patients with 22q11.2 Deletion Syndrome

Ali Mahmoud Ghanem, Tiffanie‐Marie Borg, Gehad Youssef, Deborah A. Ridout et autres

OBJECTIVE: To evaluate the benefit of anatomical muscle dissection repair for velopharyngeal insufficiency (VPI) in patients with submucous cleft palate (SMCP) with 22q11.2 deletion syndrome. DESIGN: Retrospective blinded randomised analysis of a surgeon's management over 10 years. SETTING: The study was performed …

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Simulation Training Approach for Cleft Lip and Palate Repair in Low-Income Countries

Tiffanie‐Marie Borg, Sara R Solomon, Rik Alfarrouh, Wael Barazi et autres

Background During periods of civil strife, the need for trauma care and lack of sufficient cleft surgeons causes an increase in children left untreated with cleft lip and palate deformities. During the Syrian war, some cleft care was provided through visiting charities, …

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