Deniz Sunnetci‐Akkoyunlu

Identification of Common miRNAs Differentially Expressed in Periodontitis and Pancreatic Cancer

Deniz Sunnetci‐Akkoyunlu, Cansu Ugurtas, Nurhan Kulcu-Sarikaya, Tolgahan Özer et autres

BACKGROUND/AIM: Periodontitis is a prevalent multifactorial, oral infectious disease and is considered a high-risk factor for pancreatic cancer. Nevertheless, there is limited understanding of the underlying epigenetic mechanisms governing this relationship. The aim of this study was to identify dysregulated miRNAs associated …

tr (code pays fourni par la source)

Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder

Stéphanie Efthymiou, Cailyn P Leo, Chenghong Deng, Sheng‐Jia Lin et autres

The post-transcriptional modification of tRNAs plays a crucial role in tRNA structure and function. Pathogenic variants in tRNA-modification enzymes have been implicated in a wide range of human neurodevelopmental and neurological disorders. However, the molecular basis for many of these disorders remains …

gb, us, de, pk, ca, fr, es, nl, tr, se, dk, ir, in, sa, my (code pays fourni par la source)

Potential Common Molecular Mechanisms Between Periodontitis and Prostate Cancer: A Network Analysis of Differentially Expressed miRNAs

Aylin Kanlı, Deniz Sunnetci‐Akkoyunlu, Nurhan Kulcu-Sarikaya, Cansu Ugurtas et autres

BACKGROUND/AIM: Prostate cancer is the second leading cause of cancer-related deaths in men. Periodontitis is considered a high-risk factor for prostate cancer, but the genetic mechanism is unclear. This study aims to identify dysregulated miRNAs, their associated genes, signaling pathways, and compounds …

tr (code pays fourni par la source)

Biallelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a syndromic neurodevelopmental disorder

Stéphanie Efthymiou, Cailyn P Leo, Chenghong Deng, Kejia Zhang et autres

Abstract The post-transcriptional modification of tRNAs plays a key role in tRNA folding and function to ensure proper levels of protein synthesis during growth and development. Pathogenic variants in tRNA modification enzymes have been implicated in diverse human neurodevelopmental and neurological disorders. …

gb, us, de, au, pk, ca, fr, nl, tr, se, dk, ir, in, sa (code pays fourni par la source)

Differentially expressed miRNAs associated with generalized aggressive periodontitis

Esra Guzeldemir-Akcakanat, Deniz Sunnetci‐Akkoyunlu, V. Merve Balta‐Uysal, Tolgahan Özer et autres

tr (code pays fourni par la source)

Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis

Deniz Sunnetci‐Akkoyunlu, Esra Guzeldemir-Akcakanat, Begum Alkan, Büşra Gürel et autres

BACKGROUND: Our previous study explored the molecular signatures of generalized aggressive periodontitis (GAgP) using gingival tissues through omics-based-whole-genome transcriptomic analysis. This continuation study aimed to investigate the whole protein profiling of these gingival samples through liquid chromatography-mass spectroscopy/mass spectroscopy (LC-MS/MS) analysis and …

tr (code pays fourni par la source)

The role of next‐generation sequencing in the examination of signaling genes in Brca1/2‐negative breast cancer cases

Naci Çine, Cansu Ugurtas, Merve Ertan Gökbayrak, Duygu Aydın et autres

INTRODUCTION: Breast cancer is the most prevalent malignancy in women worldwide. Although pathogenic variants in the BRCA1/2 genes are responsible for the majority of hereditary breast cancer cases, a substantial proportion of patients are negative for pathogenic variations in these genes. In …

tr (code pays fourni par la source)

The diagnostic importance of pathogenic variants and variant coexistence determined by NGS-based liquid biopsy approach in patients with lung adenocarcinoma

Naci Çine, Emin Ali Sen, Gulhan Demir, Merve Ertan Gökbayrak et autres

tr (code pays fourni par la source)

TP53, EGFR and PIK3CA gene variations observed as prominent biomarkers in breast and lung cancer by plasma cell-free DNA genomic testing

Hakan Savlı, Nilüfer Sertdemir, Duygu Aydın, Bilge Dursun et autres

tr (code pays fourni par la source)

Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis

Esra Guzeldemir-Akcakanat, Begum Alkan, Deniz Sunnetci‐Akkoyunlu, Büşra Gürel et autres

BACKGROUND: To elucidate molecular signatures of chronic periodontitis (CP) using gingival tissue samples through omics-based whole-genome transcriptomic and whole protein profiling. METHODS: Gingival tissues from 18 CP and 25 controls were analyzed using gene expression microarrays to identify gene expression patterns and …

tr (code pays fourni par la source)

Gene‐Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network‐Based Microarray Analysis

Esra Guzeldemir-Akcakanat, Deniz Sunnetci‐Akkoyunlu, Begum Orucguney, Naci Çine et autres

BACKGROUND: In this study, molecular biomarkers that play a role in the development of generalized aggressive periodontitis (GAgP) are investigated using gingival tissue samples through omics-based whole-genome transcriptomics while using healthy individuals as background controls. METHODS: Gingival tissue biopsies from 23 patients …

tr (code pays fourni par la source)