Ana L. Martínez‐López

Covalent Arabinoxylans Nanoparticles Enable Oral Insulin Delivery and Gut Microbiota Modulation in Diabetes

Yubia Berenice De Anda-Flores, Elizabeth Carvajal-Millan, Marcel Martínez-Porchas, Agustin Rascon-Chu et autres

Arabinoxylans (AX) are polysaccharides capable of forming covalent gels stable under variations in pH and temperature. They are fermentable by the colonic microbiota, making them appropriate carriers for colon-targeted oral drug delivery, including insulin. This study aimed to fabricate covalent AX nanoparticles …

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“Bertita” Cáceres en el teatro: Entrevista con Hermes Reyes y su lucha por la justicia social en Honduras

Ana L. Martínez‐López

Uso del teléfono móvil a través del aula invertida en el curso de Geografía del nivel medio superior

Eduardo Domínguez Herrera, Ana L. Martínez‐López

El objetivo general de este estudio mixto es analizar el uso del teléfono móvil fuera del salón de clases durante la Unidad 1 “Sociedad cambiante y dinámica” del curso de Geografía, integrando el modelo del aula invertida. Los resultados de esta investigación …

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Rapamycin-loaded nanostructured lipid carrier modified with folic acid intended for breast cancer therapy

Camila Fernanda Rodero, Marcela Tavares Luiz, Mariana Rillo Sato, Fernanda Isadora Boni et autres

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Zein nanoparticles extend lifespan in C. elegans and SAMP8 mice

Ana L. Martínez‐López, Cristian Reboredo, Carlos J. González-Navarro, Maite Solas et autres

Empty zein nanoparticles (NP) have been shown to lower glycemia in rats by stimulating the secretion of endogenous GLP-1. This study evaluated the effect of these nanoparticles on the lifespan of two animal models: C. elegans fed with a glucose-rich diet and …

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Enzymatic Treatment of Ferulated Arabinoxylans from Distillers Dried Grains with Solubles: Influence on the Fabrication of Covalent Electro-Sprayed Nanoparticles

Yubia De Anda-Flores, Jaime Lizardi‐Mendoza, Agustín Rascón‐Chu, J. Tánori et autres

Arabinoxylans (AXs) extracted from distillers dried grains with solubles (DDGSs) were treated with amylase, amyloglucosidase, and protease, to evaluate their effect on the polysaccharide capability to form covalent electro-sprayed nanoparticles. Enzymatically treated arabinoxylans (AXPPs) presented a significant decrease in protein content and …

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Encapsulated Phytomedicines against Cancer: Overcoming the “Valley of Death”

Ana Brotons-Canto, Claudia Urueña, Izaskun Imbuluzqueta, Edurne Luque-Michel et autres

, which has shown the ability to reduce primary tumors and metastasis in animal models of cancer, by mechanisms involving the increase in intracellular Ca++, reticulum stress, induction of autophagy, and subsequent activation of the immune system. Although P2Et has been shown …

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Fine structural features and antioxidant capacity of ferulated arabinoxylans extracted from nixtamalized maize bran

Jorge Márquez-Escalante, Elizabeth Carvajal‐Millán, Ana L. Martínez‐López, Karla G. Martínez‐Robinson et autres

Abstract BACKGROUND The nixtamalization process improves the nutritional and technological properties of maize. This process generates nixtamalized maize bran as a by‐product, which is a source of arabinoxylans (AX). AX are polysaccharides constituted of a xylose backbone with mono‐ or di‐arabinose substitutions, …

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Encapsulation of Lactobacillus plantarum in casein-chitosan microparticles facilitates the arrival to the colon and develops an immunomodulatory effect

Rebeca Peñalva, Ana L. Martínez‐López, Carlos Gamazo, Carlos J. González-Navarro et autres

The current work describes the capability of casein-chitosan microparticles to encapsulate Lactobacillus plantarum (CECT 220 and WCFS1 strains) and evaluates their ability to target the distal areas of the gut and to stimulate the immune system. Microparticles were prepared by complex coacervation, …

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Oral administration of zein-based nanoparticles reduces glycemia and improves glucose tolerance in rats

Cristian Reboredo, Carlos J. González-Navarro, Ana L. Martínez‐López, Juan M. Irache

The aim was to evaluate the effect of zein-based nanoparticles on the glucose homeostasis, following oral administration to Wistar rats. For this purpose, bare nanoparticles (NP, with tropism for the upper intestinal regions) and poly(ethylene glycol)-coated nanoparticles (NP-PEG), with the capability to …

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Arabinoxylans-Based Oral Insulin Delivery System Targeting the Colon: Simulation in a Human Intestinal Microbial Ecosystem and Evaluation in Diabetic Rats

Ana L. Martínez‐López, Elizabeth Carvajal‐Millán, Rafael Canett‐Romero, Satya Prakash et autres

Arabinoxylans (AX) microcapsules loaded with insulin were prepared by enzymatic gelation of AX, using a triaxial electrospray method. The microcapsules presented a spherical shape, with an average size of 250 µm. The behavior of AX microcapsules was evaluated using a simulator of …

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Zein-Based Nanoparticles as Oral Carriers for Insulin Delivery

Cristian Reboredo, Carlos J. González-Navarro, Ana L. Martínez‐López, Cristina Martínez-Ohárriz et autres

Zein, the major storage protein from corn, has a GRAS (Generally Regarded as Safe) status and may be easily transformed into nanoparticles, offering significant payloads for protein materials without affecting their stability. In this work, the capability of bare zein nanoparticles (mucoadhesive) …

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