Accès ouvert
2026
article
OpenAlex
Jennifer To, Timothy Müller, Oliver Bozinov, Luca Regli et autres
OBJECTIVE: To assess the impact of intraoperative MRI (ioMRI) on the extent of resection (EoR) in pediatric brain tumor surgery and evaluate the benefits and limitations of its routine implementation. METHODS: Observational single-center study, including prospectively collected data of 118 ioMRI-guided intracranial …
ch
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Accès ouvert
2026
review
OpenAlex
Tristan Schmidlechner, Vittorio Stumpo, Elisabeth Jehli, Leonie Zerweck et autres
Glioma imaging remains constrained by the limited ability of conventional MRI to capture biologically relevant tumor features beyond blood-brain barrier disruption. Hypoxia-modulated blood oxygen level-dependent (BOLD) MRI has emerged as a potential contrast-agent-free approach to probe oxygenation-related tumor physiology, using deoxyhemoglobin as …
ch
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Alexis Paul Romain Terrapon, Erik Schulz, Athina Firtinidou, Silvio A. Heinig et autres
Background: Postoperative outcome assessment is often based on discrete follow-up visits, limiting characterization of individual recovery trajectories, and the timely identification of adverse events (AEs). Longitudinal smartphone-based monitoring may overcome these limitations by enabling frequent, resource-efficient collection of patient-reported outcomes and complications …
ch
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Marco Galeazzi, Clarissa Ann Elisabeth Gelmi, Elisa Colombo, Schirin Rahiminia et autres
BACKGROUND: Vestibular schwannoma resection is among the most technically demanding procedures in neurosurgery. Reduced operative exposure during residency has increased the need for realistic and accessible simulation models. METHODS: A training model was created by combining human placenta with a 3D-printed retrosigmoid …
it, ch
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Leonie Zerweck, Tristan Schmidlechner, Vittorio Stumpo, Elisabeth Jehli et autres
PURPOSE: Hypoxia-targeted blood oxygen level-dependent (BOLD) MRI is an emerging non-contrast imaging technique for characterizing tumor biology in isocitrate dehydrogenase-wildtype glioblastoma. Beyond the magnitude of BOLD signal changes, signal heterogeneity may provide valuable information about tumor aggressiveness and microenvironmental complexity. The aim …
ch
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Daniel de Wilde, Olivier Zanier, Aron Alakmeh, Stefanos Voglis et autres
INTRODUCTION: Meningiomas are the most common primary intracranial tumors and are frequently monitored over extended periods. Volumetric assessment typically requires manual segmentation, which is time-consuming and associated with interrater variability. This study aimed to develop and validate a deep learning-based model for …
ch, gb, de, se
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Kenneth Arockia, Massimo Bottini, Anita Maria Klukowska, Victor Gabriel El-Hajj et autres
PURPOSE: Simple generalized thresholds for assessing functional impairment in clinical testing are limited, as they fail to consider patient-specific properties such as age, body height, and body mass index. A previously developed machine learning-based model for personalized testing using the five-repetition sit-to-stand …
ch, pl, se, at
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Daniel de Wilde, Benjamin Schärli, Kym Ackermann, Massimo Bottini et autres
BACKGROUND: Advances in generative artificial intelligence (AI) have accelerated the development and application of synthetic medical imaging. Despite this rapid progress, the evaluation of synthetic medical images remains heterogeneous, with numerous metrics proposed to assess fidelity, realism, diversity, and clinical validity. Currently, …
ch, se
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Raffaele Da Mutten, Sven Theiler, Massimo Bottini, Daniel de Wilde et autres
Segmentations of the vertebral column that include anatomical subregions can be used for patient education, pedicle screw planning, or radiomic feature extraction for spinal surgery. Deep learning has proven successful in tackling medical image segmentation; therefore, we aim to train a multiclass …
ch, gb, de, se, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Sebastian L. Wyss, Jorn Fierstra, Victor Staartjes, Stefanos Voglis et autres
BACKGROUND: To identify the clinical timepoint of World Federation of Neurosurgical Societies (WFNS) grading that provides the highest prognostic accuracy for short- and long-term outcomes in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: In this cohort study of 389 patients, WFNS grades were recorded …
ch
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Kevin Akeret, Raphael M. Buzzi, Thomas Gentinetta, Moritz Saxenhofer et autres
OBJECTIVES: To validate whether cerebrospinal fluid oxyhaemoglobin (CSF-Hb), measured from external ventricular or lumbar drains, is associated with secondary brain injury (SAH-SBI) after aneurysmal subarachnoid haemorrhage (aSAH) and to assess its value as a real-time monitoring biomarker. DESIGN: Pre-registered multicentre prospective observational …
ch, us, de, at
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Benjamin M. Beyersdorf, Stefanos Voglis, Zsolt Kulcsár, Luca Regli et autres
Background/Objectives: Brain arteriovenous malformations (bAVMs) are complex cerebrovascular lesions that carry a substantial risk of intracranial hemorrhage, yet the biological mechanisms underlying vascular remodeling remain incompletely understood. As increasing evidence suggests that inflammatory processes contribute to vascular remodeling and bAVM progression, this …
ch, de
(code pays fourni par la source)