Jonas Bergan

A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine R. Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

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Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Frauke C. Degenhardt, David Ellinghaus, Simonas Juzėnas, Jon Lerga-Jaso et autres

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a …

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Patient outcomes after electrical injury – a retrospective study

Jamal Ahmed, Charlotte Stenkula, Sherwan Omar, Josef. P. Ghanima et autres

INTRODUCTION: People exposed to electrical injuries are often admitted to hospital for observation. Current evidence suggests that patients who have a normal ECG on admission after a low-voltage injury, with no loss of consciousness or initial cardiac arrest may be discharged home …

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Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Frauke C. Degenhardt, David Ellinghaus, Simonas Juzėnas, Jon Lerga-Jaso et autres

ABSTRACT Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a …

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Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha S. Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

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Seventy patients treated for COVID-19 by Østfold Hospital Trust

Siri Øverstad, Eirik Brekka Tjønnfjord, Magnus Kringstad Olsen, Jonas Bergan et autres

BACKGROUND: There is a need for further data on the COVID-19 situation in Norway. Our aim was to describe the patients admitted to our local hospital with COVID-19 in the spring of 2020. MATERIAL AND METHOD: Data were retrieved retrospectively from our …

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Venous thromboembolism and coronavirus disease 2019 in an ambulatory care setting - A report of 4 cases

Siri Øverstad, Eirik Brekka Tjønnfjord, Lamya Garabet, Synne Gronvold Fronas et autres

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70 patients with COVID-19 admitted to Ostfold Hospital

Siri Øverstad, Eirik Brekka Tjønnfjord, Michelle Olsen, Jonas Bergan et autres

Exogenous lysophospholipids with large head groups perturb clathrin‐mediated endocytosis

Ieva Ailte, Anne Berit Dyve Lingelem, Audun Sverre Kvalvaag, Simona Kavaliauskiene et autres

In this study, we have investigated how clathrin-dependent endocytosis is affected by exogenously added lysophospholipids (LPLs). Addition of LPLs with large head groups strongly inhibits transferrin (Tf) endocytosis in various cell lines, while LPLs with small head groups do not. Electron and …

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Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding

Ieva Ailte, Anne Berit Dyve Lingelem, Simona Kavaliauskiene, Jonas Bergan et autres

Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells whereas LPLs …

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Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics

Tore Skotland, Kim Ekroos, Simona Kavaliauskiene, Jonas Bergan et autres

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List of Contributors

Klaus Aktories, Alberto Alape‐Girón, Julien Barbier, Joseph T. Barbieri et autres

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