Rohan Chaubal

Genomic Alterations Converge on Lipid Metabolism and ERBB2 in Breast Cancer.

Shantanu Chowdhury, Divya Khanna, Arnab Ghosh, Priyanka Bhadwal et autres

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Correction: Patient derived xenograft models of hormone receptor positive and HER2 negative breast cancer from Indian patients

Khusbhoo A. Gandhi, Rohan Chaubal, Elizabeth Talker, Jaya Chitra Aadhi et autres

The original version of this Article contained an error in Figure 5, where one image corresponding to the G1 mice was inadvertently mislabelled as G0 during microscopy image acquisition and subsequent file organization. This mislabelling resulted in the incorrect assignment of a …

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Hypoxia-reoxygenation cycle leads to context dependent phenotypic effects in breast cancer cell lines

Jinesh Maniar, Pranali Dhas, Pulkit Datt, Prerana Dange et autres

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Establishment and Molecular Characterization of a Short‐Term Primary Culture Derived From Invasive Micropapillary Carcinoma of the Breast

Mamta Gurav, Omshree Shetty, Shalaka Joshi, Seema Gulia et autres

Invasive micropapillary carcinoma (IMPC) of the breast, a rare and aggressive subtype, represents a unique morphology of reversed polarity with higher metastatic propensity. Due to the limited availability of experimental models, understanding distinct molecular pathways and potential therapeutic targets remains challenging. This …

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CDKN1B inactivation impacts ER signaling and drives resistance to endocrine therapy in breast cancer

Suhail Ahmad, Ashwin Butle, Akshay Karn, Roma Sunder et autres

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Whole-Genome Landscape of Breast Cancers from India shows Distinct Clinically Actionable Subtypes

Divya Khanna, Arnab Ghosh, Priyanka Bhadwal, Ramakanth Chirravuri-Venkata et autres

Abstract Breast cancer remains the leading cause of cancer-related mortality among women globally, yet South Asian populations are critically underrepresented in genomic studies. Here, we present whole-genome and transcriptome analyses of over 500 treatment-naïve, clinically annotated breast tumors from India, representing the …

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Clinically actionable alterations in Indian breast cancer patients derived through whole transcriptome sequencing

Nilesh Gardi, Rohan Chaubal, Khushboo Gandhi, Anushree Kadam et autres

Background and objectives Genomic studies are essential for identifying mutations that may influence key aspects of breast tumours, such as susceptibility, aggressiveness, and response to treatment. There are deficient molecular and genomic data from Indian breast cancer patients. Methods mRNA from primary …

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Patient derived xenograft models of hormone receptor positive and HER2 negative breast cancer from Indian patients

Khushboo Gandhi, Rohan Chaubal, Elizabeth Talker, Jaya Chitra Aadhi et autres

Limited success has been achieved in the development of patient-derived xenografts (PDX) models of hormone receptor-positive (HR+), Human Epidermal growth factor Receptor 2-negative (HER2-negative) metastatic breast cancers that are resistant to hormone therapy (HT). We aimed to establish and characterize PDX models …

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Genomic landscape of hormone therapy-resistant HR-positive, HER2-negative breast cancer

Rohan Chaubal, Elizabeth Talker, Jaya Chitra, Rasika Kadam et autres

PURPOSE: We aimed to characterize the genomic landscape of hormone receptor-positive (HR+)/HER2-negative breast cancer in patients with hormone therapy-resistant and -sensitive phenotypes. METHODS: HR+/HER2-negative patients who were disease-free for ≥2 years were considered hormone therapy-sensitive (n = 19), while those who experienced …

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Abstract P5-06-08: Molecular features of Pregnancy Associated Breast Cancer from a tertiary care cancer centre in India

Jyoti Bajpai, Rohan Chaubal, Rajiv Sarin, Venkatesh Kapu et autres

Abstract Background: Pregnancy-associated breast cancer (PABC) encompassing breast cancer diagnosed during pregnancy or one-year post-partum is a rare and challenging entity wherein oncologists need to safeguard maternal oncological and foetal outcomes simultaneously. Little is known about genomic signatures which is worth exploring …

Circulating tumour DNA as a promising biomarker for breast cancer diagnosis & treatment monitoring

Riddhi Ursekar, Rohan Chaubal, Khushboo Gandhi, Elizabeth Talker et autres

Breast cancer contributes a large fraction to mortality among women diagnosed with cancer. It is important to monitor residual disease and extend the lead time to detect relapse in high-risk patients. Minimally invasive techniques that utilise circulating biomarkers are being explored for …

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Integration of Organoids With CRISPR Screens: A Narrative Review

Rushikesh Mukhare, Khushboo Gandhi, Aishwarya Raja, Ankita Singh et autres

Organoids represent a significant advancement in disease modeling, demonstrated by their capacity to mimic the physiological/pathological structure and functional characteristics of the native tissue. Recently CRISPR/Cas9 technology has emerged as a powerful tool in combination with organoids for the development of novel …

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