Likun Hou

Diffuse co-expression of TTF-1 and p40 (ΔNp63) defines a distinct biphenotypic non-small cell lung carcinoma: clinicopathologic and molecular characterization of 19 cases

Jielu Lin, S. Li, Weijie Chen, W. wu et autres

BACKGROUND: The diffuse co-expression of thyroid transcription factor-1 (TTF-1) and p40 defines a rare and diagnostically challenging subtype of non-small cell lung carcinoma (NSCLC). Due to its extreme rarity, the clinicopathologic and molecular characteristics of this entity remain poorly characterized. METHODS: We …

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A 7-gene expression signature predicts immune microenvironment remodeling and neoadjuvant chemo-immunotherapy response in lung squamous cell carcinoma

S. Li, Junhong Guo, Yan Huang, Zhengwei Dong et autres

Background Neoadjuvant chemo-immunotherapy (NCI) has significantly improved outcomes in advanced lung squamous cell carcinoma (LUSC). However, some patients remain resistant to NCI, resulting in poor outcomes. The mechanisms behind this resistance remain unclear. Methods Forty LUSC patients receiving NCI were selected and …

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Development of antibody drug conjugates targeting epithelial membrane protein 2-highly expressed lung cancer

Mengge Zheng, Hang Su, Changyong Hu, Jianxia Chen et autres

Lung cancer is one of the most devastating types of cancer, and the treatment of lung cancer has been facing great challenges. Antibody-drug conjugates (ADCs), a new type of targeted therapy, have been widely used in cancer therapy and have opened up …

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Predicting Spatial Transcriptomics from H&E Image by Pretrained Contrastive Alignment Learning

Jiawei Zou, Kai Xiao, Jing Xu, Tao Chen et autres

Abstract The intricate molecular landscape within tissues holds crucial information about cellular behavior and disease progression, yet capturing this complexity at a spatial level remains challenging. While Spatial transcriptomics (ST) offers valuable insights into gene expression patterns within their native tissue context, …

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Robust Autocorrelation for Period Detection in Time Series

Zhi Yang, Likun Hou, Xing Zhao

CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer

Haowei Wang, Anwen Xiong, Xiaoxia Chen, Junhong Guo et autres

Abstract Although third-generation Epidermal growth factor receptor—tyrosine kinase inhibitors (EGFR-TKI) is standard of care for patients with EGFR-mutant Non-small cell lung cancer (NSCLC), little is known about the predictors of response or resistance. Here, we integrated single-cell RNA (scRNA) sequencing, bulk RNA …

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Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature

Wang RanYue, Chunyan Wu, Likun Hou, Zhang Li-ping et autres

Mesothelioma, with various clinical manifestations, radiological features, and histomorphological types, can be divided into epithelioid, sarcomatoid, and biphasic types, according to their histomorphological characteristics. There is a rare growth pattern of pleural mesothelioma: diffuse intrapulmonary mesothelioma (DIM), with a distinctive pattern of …

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Three-objective optimization of boiler combustion process based on multi-objective teaching–learning based optimization algorithm and ameliorated extreme learning machine

Yunpeng Ma, Heqi Wang, Xinxin Zhang, Likun Hou et autres

The combustion optimization problem of Circulation Fluidized Bed Boiler (CFBB) can be regarded as a constrained dynamic multi-objective optimization problem, so it has become a hot research to solve the problem for saving energy and reducing polluting gas. However, it is difficult …

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Identify Candidate Genes in the Interaction between Abdominal Aortic Aneurysm and Type 2 Diabetes Mellitus by Using Biomedical Discovery Support System

Zu Honglin, Likun Hou, He Ju

Objective To explore the candidate genes that play significant roles in the interconnection between abdominal aortic aneurysm (AAA) and type 2 diabetes mellitus (DM). Methods We used the Biomedical Discovery Support System (BITOLA) to screen out the candidate intermediate molecular (CIM) "Gene …

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PD-L1 expression and its effect on clinical outcomes of EGFR-mutant NSCLC patients treated with EGFR-TKIs

Bai Yuchen, Likun Hou, Jun Qian, Tao Jiang et autres

OBJECTIVE: Epidermal growth factor receptor (EGFR) activation was reported to upregulate programmed death-ligand 1 (PD-L1) expression in lung cancer cells and subsequently contribute to immune escape, indicating its critical role in EGFR-driven lung tumors. This study characterized PD-L1 expression in patients with …

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Image restoration by minimizing zero norm of wavelet frame coefficients

Chenglong Bao, Bin Dong, Likun Hou, Zuowei Shen et autres

Abstract In this paper, we propose two algorithms, namely the extrapolated proximal iterative hard thresholding (EPIHT) algorithm and the EPIHT algorithm with line-search, for solving the ℓ 0 -norm regularized wavelet frame balanced approach for image restoration. Under the theoretical framework of …

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CUSTOM: A Calibration Region Recovery Approach for Highly Subsampled Dynamic Parallel Magnetic Resonance Imaging

Xue Zhang, Likun Hou, Hao Gao, Xiaoqun Zhang

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