Hao Gao

Evaluation of GAN-Based Left Ventricle CMR Image Synthesis in the Sparse Data Regime

Zhengduo Zhao, Alan Lazarus, Jose Antonio Oga, Stephen Law et autres

Generative modelling has become a promising approach to address data scarcity in medical imaging, where large annotated datasets may not always be available.This study assesses the potential of Generative Adversarial Networks (GANs) for synthesising anatomically realistic left ventricular (LV) cardiac magnetic resonance …

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EXPERIMENTAL DEMONSTRATION OF PROTON MINIBEAM DELIVERY AT FLASH DOSE RATES

Yuting Lin, Wei Wu, Jufri Setianegara, Aoxiang Wang et autres

Computationally-efficient constrained constructive optimisation algorithm for patient-specific coronary microvascular network generation

Namshad Thekkethil, Jay Mackenzie, Giovanni Pelagi, Hao Gao et autres

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Linear stability analysis of a collapsible channel flow

Danyang Wang, Hao Gao, Zishun Liu

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A Physics-Informed Kolmogorov–Arnold Graph Attention Network for solid mechanics on arbitrary geometries

Zheng Duanmu, Ning Meng, Qi Zhang, Hao Gao et autres

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A modelling study of right ventricular growth with valvular regurgitation

Debao Guan, Hao Gao

Right ventricular (RV) dysfunction due to pulmonary and tricuspid valve regurgitation remains understudied despite its critical role in adverse cardiac outcomes. We present a biventricular computational model that integrates regurgitant valves in the RV with a kinematic growth framework. Updated reference configurations …

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Analysis of homeostatic biomechanical thresholds in a left ventricular model of growth and remodelling

Debao Guan, Xinyang Ge, Qiaolan Wu, Hao Gao

Biomechanical models of myocardial growth and remodelling (G&R) are often modelled as responses to deviations from a preferred biomechanical homeostatic state, triggered by stretch or stress. Yet how these critical values of stretch and stress should be defined remains unresolved. This study …

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Left Atrial Appendage Closure With Different Antithrombotic Therapies in Patients at High Bleeding Risk: A 10-Year Cohort Study

Xiaoqi Niu, Xu Tang, Xiaonan Fang, Xiulin Liu et autres

BACKGROUND: In this study we aimed to evaluate the safety and efficacy of different antithrombotic strategy after left atrial appendage closure (LAAC) in high bleeding risk patients with nonvalvular atrial fibrillation. METHODS: In this study we included 893 patients with high bleeding …

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Evaluation of an open-face 8-channel transmit 64-channel receive 7T head coil for neuroimaging

Natasha E. Fullerton, Belinda Ding, Sydney N. Williams, Sarah Allwood-Spiers et autres

Introduction Ultra-high field (UHF) 7 tesla (7T) MRI offers unique diagnostic opportunities for clinical neuroimaging. However, broader clinical implementation remains limited because the reduced radiofrequency (RF) wavelength at 7T causes RF transmit field ( B 1 + ) inhomogeneity, resulting in spatial …

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Two-view CBCT Reconstruction via Preconditioned Gradient Descent with Plug-and-play Diffusion Anatomical Prior

Ji Li, Qilong Guo, Li Lv, Yikun Zhang et autres

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Finite-element Gaussian processes for the machine learning of steady-state linear partial differential equations

David R. Dalton, Hao Gao, Dirk Husmeier

We introduce finite-element Gaussian processes (FEGPs), a novel physics-informed machine learning approach for solving inverse problems involving steady-state, linear partial differential equations (PDEs). Our framework combines a Gaussian process prior for the unknown solution function with a likelihood that incorporates the PDE …

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SPP1 + macrophage and Treg interaction mediates immunosuppression and adverse survival in HER2 + breast cancer

Hao Gao, Kangjie Shen, Luhong Chen, Chao Huang et autres

Human epidermal growth factor receptor 2 (HER2) -positive breast cancer exhibits aggressive clinical progression and unfavorable outcomes. While HER2-directed agents and immune checkpoint inhibitors have transformed clinical management, persistent challenges include suboptimal response rates and acquired resistance. These limitations underscore the critical …

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