Elena De Santis

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Maura Di Vito, Elena De Santis, Giulietta Anna Perrone, Emanuela Mari et autres

TPC is 3-4 fold more common in premenopausal women than in men, suggesting an involvement of estrogens and their receptors (ERs) in the growth and progression of this tumor. ER alpha (ER-A) and ER beta (ER-B) play a different role in the …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Elena De Santis, Tania Arcangeli, Ilaria Carnevale, Luigi Michele Coppola et autres

Fabry’s disease (FD) is a genetic X-linked systemic and progressive rare disease, which is characterized by the accumulation of glycolipid bodies (GB) into the lys- osomes of almost all cell types and consequently by a multiform clinical picture. Here we studied testicular …

P18.12.A CTX-CNF1 BOOSTS GLIOBLASTOMA SURVIVAL BY REPROGRAMMING THE IMMUNE MICROENVIRONMENT

Ênio Mori, Elena De Santis, M Scalera, J Meissel et autres

Abstract BACKGROUND Glioblastoma (GB) is an aggressive brain tumor with limited treatment options and poor prognosis. Immune evasion is a hallmark of GB, contributing to resistance against conventional and emerging therapies. This study investigates the therapeutic potential of CTX-CNF1, a novel recombinant …

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Roles of Peripheral Nerves in Tumor Initiation and Progression

Claudia Giampietri, Elisa Pizzichini, Francesca Somma, Simonetta Petrungaro et autres

In recent years, a long list of relevant studies has highlighted the engagement of the nervous system in the fine-tuning of tumor development and progression. Several authors have shown that different types of nerve fibres (sympathetic, parasympathetic/vagal or somatosensory fibres) may contribute …

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POS0271 AUTOANTIBODIES AND OVERLAP SYNDROMES: SHAPING THE LANDSCAPE OF ILD RISK IN SYSTEMIC SCLEROSIS

M. de Pinto, Martina Orlandi, Amelia Spinella, Alessandra Melegari et autres

Background: Interstitial lung disease (ILD) represents a frequent and severe complication of systemic sclerosis (SSc), affecting approximately 50% of patients, with a progressive phenotype observed in 40%. Despite advancements in therapeutic strategies, ILD remains a leading cause of mortality in SSc, underscoring …

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Genitofemoral nerve course and branching variations: what we see during laparoscopic extended pelvic lymph-node dissection in radical prostatectomy for prostate cancer, and how to avoid intraoperative lesions: a retrospective analysis

Elena De Santis, Carlo Introini, Anastasios D. Asimakopoulos, Roberto Cirocchi et autres

BACKGROUND: The genitofemoral nerve is the most variable nerve of the lumbar plexus in terms of its course and bifurcation, and therefore it must be taken into consideration during extended pelvic lymph node dissection. Its borders, during robotic, laparoscopic or open radical …

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P02.18.A MOLECULAR CHANGES UNDERLYING DECAY OF SENSORY RESPONSES AND ENHANCED SEIZURE PROPENSITY IN PERITUMORAL NEURONS

Elena De Santis, Elena Tantillo, M Scalera, Nicolò Meneghetti et autres

Abstract BACKGROUND Glioblastoma growth impacts on the structure and physiology of peritumoral neuronal networks, altering the activity of pyramidal neurons which drives further tumor progression. It is therefore of paramount importance to identify glioma-induced changes in pyramidal neurons, since they represent a …

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P02.17.B MANIPULATING GABAERGIC MECHANISMS TO DELAY GLIOMA INVASION IN PERITUMORAL MICROENVIRONMENT

M Scalera, Elena De Santis, Arianna Sturlese Verduri, Nicolò Meneghetti et autres

Abstract BACKGROUND The interaction between tumor cells and the main components of the tumor microenvironment (TME) seems to guide the progression of glioma. Several recent studies have highlighted that the synaptic activity of pyramidal neurons potently drives Glioblastoma (GB) proliferation. However, the …

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Altered centriolar cohesion by CEP250 and appendages impact outcome of patients with pancreatic cancer

Guido Giordano, Giampiero Cipolletta, Agostino Mellone, Giovanni Puopolo et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading cause of cancer death worldwide. PDACs are characterized by centrosome aberrations, but whether centrosome-related genes influence patient outcomes has not been tested. METHODS: Publicly available RNA-sequencing data of patients diagnosed with PDAC …

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Primary Anaplastic-Lymphoma-Kinase-Positive Large-Cell Lymphoma of the Central Nervous System: Comprehensive Review of the Literature

Antonio Colamaria, Augusto Leone, Francesco Carbone, Yasser Andres Dallos Laguado et autres

BACKGROUND: Primary anaplastic-lymphoma-kinase (ALK)-positive large-cell lymphoma of the central nervous system (PCNS ALK-positive ALCL) is a rare entity, with a limited consensus reached regarding its management. While this pathology often presents as solitary lesions, the occurrence of multiple tumors within the brain …

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SENESCENCE, METABOLIC ACTIVITY AND APOPTOSIS IN PRIMARY AND TUMORAL CELL LINES FOLLOWING FLASH AND CONVENTIONAL RADIOTHERAPY

Mario Costa, Fabio Di Martino, Fabiola Paiar, Barbara Di Marco et autres

A Systematic Review of Varying Definitions and the Clinical Significance of Fredet’s Fascia in the Era of Complete Mesocolic Excision

Gioia Brachini, Bruno Cirillo, Matteo Matteucci, Roberto Cirocchi et autres

BACKGROUND: Fredet's fascia represents a crucial landmark for vascular surgical anatomy, especially in minimally invasive complete mesocolic excision (CME) for right-sided colon adenocarcinoma. Fredet's fascia allows access to the gastrocolic trunk of Henle (GCTH), the most critical step in both open and …

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